Serum n-3 Polyunsaturated Fatty Acids and C-Reactive Protein Concentrations Are Inversely Associated in Patients With Alcoholic Chronic Pancreatitis

Hebanowska, Areta; Mika, Adriana; Rojek, Lukasz; Stojek, Magdalena; Goyke, Elżbieta; Świerczyński, Julian; Śledziński, Tomasz; Adrych, Krystian

doi:10.1097/mpa.0000000000002024

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…2,22,40 Several studies have shown FAs like linoleic acid as well as other fatty acids in its metabolic pathway are dysregulated in patients with CP who had a history of excessive alcohol consumption compared to healthy controls. 7,41,42 In our study, the relative abundance of linoleic acid was decreased and oleic acid was increased due to alcohol use, and only linoleic acid was affected by a history of smoking in CP. Linoleic acid metabolism can result in an increase of prostaglandins that promote inflammation.…”

Section: Discussionmentioning

confidence: 46%

Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study

Gumpper

Crowe

Hart

et al. 2023

Preprint

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Objectives: Chronic pancreatitis (CP) is an inflammatory disease that affects the absorption of nutrients like fats. Molecular signaling in pancreatic cells can be influenced by fatty acids (FAs) and changes in FA abundance could impact CP-associated complications. Here, we investigated FA abundance in CP compared to controls and explored how CP-associated complications and risk factors affect FA abundance. Methods: Blood and clinical parameters were collected from subjects with (n=47) and without CP (n=22). Plasma was analyzed for relative FA abundance using gas chromatography and compared between controls and CP. Changes in FA abundance due to clinical parameters were also assessed in both groups. Results: Decreased relative abundance of polyunsaturated fatty acids (PUFAs) and increased monounsaturated fatty acids (MUFAs) were observed in subjects with CP in a sex-dependent manner. The relative abundance of linoleic acid increased, and oleic acid decreased in CP subjects with exocrine pancreatic dysfunction and a history of substance abuse. Conclusions: Plasma FAs like linoleic acid are dysregulated in CP in a sex-dependent manner. Additionally, risk factors and metabolic dysfunction further dysregulate FA abundance in CP. These results enhance our understanding of CP and highlight potential novel targets and metabolism-related pathways for treating CP.

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Section: Discussionmentioning

confidence: 46%

Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study

Gumpper

Crowe

Hart

et al. 2023

Preprint

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“…Substance abuse is another important etiologic risk factor for developing CP. Several studies have shown polyunsaturated FAs (PUFAs) like linoleic acid are decreased and MUFAs like oleic acid are increased in patients with CP who had a history of excessive alcohol consumption compared with healthy controls 7,49,50 ; however, many of these studies do not address how smoking affects FAs in patients who already have CP. In our study, we confirm that linoleic acid decreased, and oleic acid increased with alcohol use in patients with CP.…”

Section: Discussionmentioning

confidence: 99%

Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis

Gumpper-Fedus,

Crowe,

Hart

et al. 2024

Pancreas

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Objectives Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP. Materials and Methods Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22). Plasma was analyzed for FA composition using gas chromatography and compared between controls and CP and within CP. Results Palmitic acid increased, and linoleic acid decreased in CP compared with controls. Correlations between age or body mass index and FAs are altered in CP compared with controls. Diabetes, pancreatic calcifications, and substance usage, but not exocrine pancreatic dysfunction, were associated with differences in oleic acid and linoleic acid relative abundance in CP. De novo lipogenesis index was increased in the plasma of subjects with CP compared with controls and in calcific CP compared with noncalcific CP. Conclusions Fatty acids that are markers of de novo lipogenesis and linoleic acid are dysregulated in CP depending on the etiology or complication. These results enhance our understanding of CP and highlight potential pathways targeting FAs for treating CP.

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“…However, another study concluded that the neutrophil-to-lymphocyte ratio along with serum CRP levels at 48 h could be suitable for predicting SAR, and that CRP was a good predictive marker for mortality [ 365 , 366 ]. CRP levels can be higher in patients with chronic pancreatitis and type 2 DM than those with isolated chronic pancreatitis, and also, an inverse correlation has been reported for CRP and subjects with alcoholic chronic pancreatitis [ 367 , 368 ]. Moreover, a study showed that CRP can reliably predict the risks of pancreatic fistula, pancreas-specific complications, and hospital readmission, and should be considered for such conditions post-pancreaticoduodenectomy [ 369 ].…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

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The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

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Serum n-3 Polyunsaturated Fatty Acids and C-Reactive Protein Concentrations Are Inversely Associated in Patients With Alcoholic Chronic Pancreatitis

Abstract: Supplemental digital content is available in the text.

Cited by 3 publications

References 8 publications

Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study

Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study

Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

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