Serum neopterin levels and the angiographic extent of coronary arterial narrowing in unstable angina pectoris and in non–Q-wave acute myocardial infarction

Gurfinkel, Enrique P.; Scirica, Benjamin M.; Bozovich, Gerardo E.; Macchia, Alejandro; Manos, Eustaquio Juan; Mautner, Branco

doi:10.1016/s0002-9149(98)00905-9

Cited by 43 publications

(22 citation statements)

References 16 publications

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“…Neopterin is a by-product of activated macrophage metabolism, and the levels of neopterin increase in several systemic inflammatory and infectious diseases. In patients with unstable angina, those with elevated neopterin levels were more likely to be diagnosed with a non-Q-wave acute myocardial infarction and were more likely to have more severe and extensive arteriosclerosis than were patients with low neopterin levels (35). During follow-up, however, neopterin levels were not predictive for coronary events in patients with acute coronary syndromes (16).…”

Section: Markers and Mediators Of Inflammation Immune Response And mentioning

confidence: 96%

Role of Infectious and Immune Factors in Coronary and Cerebrovascular Arteriosclerosis

Stöllberger

Finsterer

2002

Clin Vaccine Immunol

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Section: Markers and Mediators Of Inflammation Immune Response And mentioning

confidence: 96%

Role of Infectious and Immune Factors in Coronary and Cerebrovascular Arteriosclerosis

Stöllberger

Finsterer

2002

Clin Vaccine Immunol

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“…In other studies. neopterin concentrations correlated with the score of atigiographically determined atherosclerotic lesions, degree of myocardial ischemia (33) and with the number of complex coronary stenoses (34). Baseline scrum neopterin concentrations were higher in women with ch rome stable angina, who subsequently developed cardiac events during follow up, than in those without cardiovascular events, similarly to patients with unstable angina (34).…”

Section: Discussionmentioning

confidence: 95%

Urinary Neopterin and Microalbuminuria in Patients Treated by Low-density Lipoprotein Apheresis

Cermanová¹,

Melichar²,

Solichová³

et al. 2005

Pteridines

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ΊΙ. Interni klinika,; Klinika onkologie a radioterapie, -'Klinika gerontologická a metabolická, 4 Katedra lékarské biofyziky, Lékarská fakulta University Karlovy a Fakultní nemocnice Hradee Králové, Czech republic. AbstractLow-density lipoprotein (LDL)-apheresis is a method of extracorporeal elimination of LDL-cholesterol in patients with severe primary lipoprotein disorders. LDL-cholesterol activates macrophages, which play an important role in atheromatous plaque formation. In the present study, we have investigated urinary neopterin, a specific marker of macrophage activation and microalbuminuria, an indicator of generalized vascular dysfunction, after a single LDL-apheresis procedure in 10 patients with severe primary lipoprotein disorder. The urinary neopterin/creatinine ratio was increased in patients compared to controls. No significant changes of the neopterin/creatinine and albumin/creatinine ratios were observed after LDL-apheresis, except a significant (p < 0.006) decrease of urinary neopterin/creatinine ratio in the evening after the apheresis. This decrease showed significant negative correlation with the pre-apheretic levels of atherogenic cholesterol fractions (p < 0.05) and with cholesterol decrease during the apheresis (p < 0.05). Urinary albumin/creatinine ratio correlated positively with total and LDL-cholesterol levels before the apheresis and with the evening urinary neopterin/creatinine ratio after the apheresis, but did not correlate with glycemia and triacylglycerides. Elevated urinary neopterin in the patients with severe primary lipoprotein disorders reflects the presence of atherosclerosis. A single LDL-apheresis procedure did not significantly affect microalbuminuria. The decrease of urinary neopterin in the evening after the apheresis corresponds with the diurnal rhythm of neopterin excretion and was less pronounced in patients with more severe hypercholesterolemia. The correlations between microalbuminuria, neopterin and pre-apheretic cholesterol concentrations indicate a possible connection between microvascular dysfunction, macrophage activity and severity of hyperlipidemia, but these results should be interpreted with caution because of small number of subjects evaluated.

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“…NF-κB связывается с промоторными участками генов и индуцирует экспрессию большого чис-ла провоспалительных и проатерогенных медиаторов: ФНОα, ИФНγ, интерлейкина 1 (ИЛ1), ИЛ6, молекул адге-зии [17]. Увеличение концентрации неоптерина в сыво-ротке обнаружено при атеросклеротическом поражении сонных [31], коронарных [16,17,32,33] и периферических артерий [16], и особенно выраженное -при остром коро-нарном синдроме [34][35][36].…”

Section: Discussionunclassified

Role of Inflammation Markers in Development of Atherosclerosis and Its Compications in Patients With Systemic Lupus Erythematosus

Popkova¹,

Panafidina²,

Новикова³

et al. 2014

rsp

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Serum neopterin levels and the angiographic extent of coronary arterial narrowing in unstable angina pectoris and in non–Q-wave acute myocardial infarction

Cited by 43 publications

References 16 publications

Role of Infectious and Immune Factors in Coronary and Cerebrovascular Arteriosclerosis

Role of Infectious and Immune Factors in Coronary and Cerebrovascular Arteriosclerosis

Urinary Neopterin and Microalbuminuria in Patients Treated by Low-density Lipoprotein Apheresis

Role of Inflammation Markers in Development of Atherosclerosis and Its Compications in Patients With Systemic Lupus Erythematosus

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