Serum neutrophil-lymphocyte ratios, C-reactive protein and sedimentation levels in Parkinson's disease

Abstract

ÖzPurpose: We aimed to investigate the systemic inflammation status by analyzing the Neutrophil/Lymphocyte (N/L) ratio, Erythrocyte Sedimentation Rate (ESR), and C -reactive protein (CRP) in patients with Parkinson's disease (PD). Materials and Methods: 101 PD patients, and 60 healthy subjects of similar age and gender were include in this study. The demographic data and duration of the disease, the drugs, duration of usage of Parkinson drugs, Hoehn-Yahr stage were noted. After full neurological examination blood samples are collected and neutrophil, lymphocyte counts, high sensitive CRP, ESR levels are detected. Results: The N/L ratio and the CRP levels were statistically higher in Parkinson's group. There was a statistically significant but weak positive correlation between the CRP levels and the N/L ratio with the disease duration. Similarly, there was a statistically significant but weak positive correlation between the CRP levels and the N/L ratios with Hoehn-Yahr stages. When the N/L rates of the Parkinson's patients were correlated with the CRP and the ESR levels separately, it was observed that there was a weak but statistically significant correlation between the CRP and the N/L ratio Conclusion: N/L ratio, and CRP levels, which are very important indicators of peripheral inflammation, was higher in PD. Our findings suggest that these biochemical markers may have a predictive value for the diagnosis of PD.Amaç: Parkinson hastalığı (PH) olan kişilerin kanlarında nötrofil/lenfosit (N/L) oranları, sedimentasyon hızı (ESR), C-reaktif protein (CRP) düzeylerini sağlıklı kişilerle karşılaştırarak değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmamıza benzer yaş ve cinsiyetten 101 PH ve 60 sağlıklı gönüllü katılımcı aldık. Hastaların sosyodemografik verileri, hastalık süreleri, kullandığı ilaçlar ve Hoehn-Yahr evreleri kaydedildi. Tam bir nörolojik muayeneden sonar hastaların kan örnekleri alınarak, nötrofil ve lenfosit sayılar, CRP ve ESR düzeyleri incelendi. Bulgular:N/L oranları ve CRP düzeyleri sağlıklı kişilerle kıyaslandığında PH olanlarda istatistiksel olarak anlamlı şekilde yüksek olduğu görüldü, ayrıca N/L oranları ile CRP düzeyleri arasında istatistiksel olarak anlamlı ancak zayıf bir korelasyonun olduğu tespit edildi. Benzer şekilde CRP düzeyleri ile N/L oranları ve Hoehn-Yahr evreleri arasında istatistiksel olarak anlamlı ancak zayıf bir korelasyonun olduğu görüldü. Hasta grubunda N/L oranları ayrı ayrı CRP ve ESR ile korele edildiğinde sadece N/L ile CRP arasında istatistiksel olark anlamlı zayıf bir korelasyon vardı. Sonuç: Çalışmamızda periferik inflamasyonun çok iyi birer göstergeleri olan N/L oranları ve CRP düzeylerinin PH' larında anlamlı olarak daha yüksek olduğunu tespit ettik. Bulgularımız bu markerların PH için tanısal değeri olabilceğini düşündürmektedir

Lymphocyte Count and Neutrophil-to-Lymphocyte Ratio Are Associated with Mild Cognitive Impairment in Parkinson’s Disease: A Single-Center Longitudinal Study

“…Akıl and colleagues [ 24 ] found that NLR values ≥ 2.25 resulted in 73% sensitivity and 74% specificity in identifying PD patients, determining higher predictive power than carcinoembryonic antigen (CEA). Similarly, another study [ 25 ] established a cut-off value of 2.39 with 65% sensitivity and 75% specificity (AUC = 0.714). Compared to these results, the present research showed for NLR lower AUC values and poorer prediction of PD diagnosis: however, it should be borne in mind that in our case-control design strict matching criteria, including cardiovascular comorbidities, were applied.…”

“…Regarding the relationship between NLR and PD-related symptoms, another work [ 26 ] failed to find statistically significant differences in NLR between 13 akinetic-rigid and 33 tremor-dominant patients. Furthermore, no association with disease severity [ 10 , 27 ] and controversial results concerning the relationship with disease duration and LEDD [ 10 , 25 , 26 ] have also been described.…”

The neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and neutrophil-to-high-density-lipoprotein ratio are correlated with the severity of Parkinson’s disease

“…However, the relationship between the NLR and PD incidence remains controversial. A previous study reported a positive correlation between the NLR and disease duration and between the Hoehn and Yahr staging scale (H&Y) score and PD incidence ( 24 ), while another study reported conflicting results ( 23 ).…”

Transcriptome Analysis Reveals a Two-Gene Signature Links to Motor Progression and Alterations of Immune Cells in Parkinson’s Disease

“…We observed the high-risk score patients with increased monocytes compared to the low-risk score patients (nominal p < 0.05, but no statistical significance after multiple testing correction) were correlated with the severity progression of motor symptoms in PD. Several studies have demonstrated that neutrophils or the neutrophil-to-lymphocyte ratio (NLR) were increased in patients with PD compared to healthy controls [50][51][52], and Solmaz et al [53] found a positive correlation between the NLR and H&Y stage. Our study showed a significant increase in neutrophils with a concomitant decrease in B cells and CD4 + T cells in PD cases with high-risk scores, which is in line with previous reports [53,54].…”

“…Several studies have demonstrated that neutrophils or the neutrophil-to-lymphocyte ratio (NLR) were increased in patients with PD compared to healthy controls [50][51][52], and Solmaz et al [53] found a positive correlation between the NLR and H&Y stage. Our study showed a significant increase in neutrophils with a concomitant decrease in B cells and CD4 + T cells in PD cases with high-risk scores, which is in line with previous reports [53,54]. Accumulated evidence showed that CD4 + T cells can infiltrate the brain to induce dopaminergic toxicity and contribute to neurodegeneration in PD [55,56].…”