Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes

Abstract

Levels of sTREM-1 correlated with sepsis severity. sTREM-1 is considerably higher in patients with shock compared to patients without shock. The serum of shocked patients could stimulate the expression of TREM-1 on U937 monocytes.

Serial changes in adiponectin and resistin in critically ill patients with sepsis: Associations with sepsis phase, severity, and circulating cytokine levels

“…Some patients of this cohort have been included in previous publications [21,22]. All patients fulfilled the criteria of sepsis, as established by the American College of Chest Physicians/Society of Critical Care Medicine consensus conference [23].…”

Diagnostic role of soluble triggering receptor expressed on myeloid cell-1 in patients with sepsis

“…[15] A study found that sTREM-1 concentration was significantly lower at admission in non-survivors than in survivors. [16] In our study, plasma sTREM-1 concentration in the early course was higher in the sepsis group than in the SIRS group and control group, and sTREM-1 concentration was higher in the survivors than in the non-survivors. The area under the ROC curve of sTREM-1 was 0.935; if sTREM-1> 135 pg/mL was set as the best threshold, there were a sensitivity of 93.8% and a specifi city of 84.7% in the diagnosis of sepsis.…”

Biomarkers in Pediatric Sepsis

“…The same study also showed a progressive decline in sTREM levels as the clinical picture improved [41]. A positive correlation has been found between sTREM and SOFA scores, as well [44]. In a comparison study between procalcitonin, CRP and sTREM it was found that sTREM levels were significantly lower in non-survivors.…”