Serum Organochlorine Pesticide Levels in Patients with Colorectal Cancer in Egypt

Soliman, A; Ma, Smith; Sp, Cooper; Ismail, Kadry; Khaled, Hussein; Ismail, Sohair; McPherson, R. Sue; Ia, Seifeldin; Ml, Bondy

doi:10.1080/00039899709602219

Cited by 65 publications

(51 citation statements)

References 23 publications

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“…Just like in other studies from the United States, Belgium and Egypt (Ahlborg et al, 1995;Charlier and Plomteux, 2002;Soliman et al, 1997), we have also observed mean total DDT levels in men higher than those of women. These results could suggest that lactation is a route of excretion, as there are studies that indicate the transfer of organochlorine residues to breastmilk (Harris et al, 2001;Waliszewski et al, 1999b), or suggest that there are other gender differences in storage and metabolism (Ahlborg et al, 1995).…”

Section: Discussionsupporting

confidence: 58%

“…Previous reports established a relationship between age and organochlorine residues levels (Stehr- Green, 1989;Soliman et al, 1997;Voorspoels et al, 2002) that we could not statistically corroborate. However, it is important to note that younger groups have high levels of detection of analysed residues, causing suspicion of exposure to pesticide residues continues to happen.…”

Section: Discussioncontrasting

confidence: 52%

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Evaluation of organochlorine pesticide residues in human serum from an urban and two rural populations in Portugal

Cruz

Lino

Silveira

2003

Science of The Total Environment

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Organochlorine pesticide residues were measured in human serum from an urban and two rural populations in Portugal, in an attempt to evaluate the contamination level of Portuguese population. Serum levels of 12 residues were determined using a validated methodology that included gas chromatography-electron-capture detection. It was made an attempt to point out the differences of contamination between rural and urban populations; and among these, if it could be established a relation with sex and with age of individuals. p,p9DDE, a-hexachlorocyclohexane (HCH), p,p9DDD, and b-HCH were the most frequently identified residues. p,p9DDE concentrations ranged from undetected to 390.5 mgyl in urban samples, and from undetected to 43.5 mgyl and to 171.2 mgyl in both rural samples. Maximum a-HCH concentration level was 114.4 mgyl in urban samples, 261.3 and 45.5 mgyl in both rural samples. Mean total DDT levels were always higher than mean total HCH levels. About p,p9DDE, in all three populations, the majority of the results above the limit of quantification were found among female sex. The analysis of different aged groups showed that younger groups continue to reveal contamination. Comparing obtained results with others from Europe, Asia and America, it was observed that Portugal is between the highest levels of contamination. ᮊ

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Section: Discussionsupporting

confidence: 58%

Section: Discussioncontrasting

confidence: 52%

Evaluation of organochlorine pesticide residues in human serum from an urban and two rural populations in Portugal

Cruz

Lino

Silveira

2003

Science of The Total Environment

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“…The study questionnaire elicited the information of demographic, residential, occupational, lifestyle and medical histories as well as reproductive changes for female subjects. The questionnaire had been used in our previous studies on the epidemiology of cancer in Egypt [34][35][36]. Following the interviews, blood samples were taken from all study subjects.…”

Section: Study Design and Study Populationmentioning

confidence: 99%

Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt

et al. 2010

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Background Hepatocellular carcinoma (HCC) is a major health problem worldwide, including Egypt. In the recent past, HCC has become the second most prevalent cancer among men in Egypt. Since HCC has not been well studied in the rural population of Egypt, this case-control study was conducted to investigate the epidemiologic risk factors of HCC in the predominantly rural region of Gharbiah, Egypt. Methods A total of 150 cases and 150 controls matched to cases on age (±5 years) and sex were recruited from the Gharbiah Cancer Society and Tanta Cancer Center. Exposure data were collected by an interviewer-administered standardized questionnaire about epidemiologic, occupational, medical and family history of HCC. Conditional logistic regression was utilized to calculate unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI). The effect modification of HCC risk between viral infection and environmental risk factors was also assessed.Results Being an industrial worker was an independent risk for developing HCC (OR 3.54, 95% CI 1.18, 10.63) after adjusting for viral infection, schistosomiasis and tobacco smoking. High relative risk of HCC was observed among HCV-infected individuals who were farmers (OR 9.60, 95% CI 3.72, 24.76), industrial workers (OR 12.90, 95% CI 4.33, 38.43) or active smokers (OR 5.95, 95% CI 2.20, 16.08). Conclusion Occupational exposure may play an important role in the development of HCC. Farming, industrial exposures and cigarette smoking may increase the risk of HCC among HCV-seropositive individuals. Future research focusing on mechanisms of occupational exposures among HCV patients in this population is needed.

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“…[25][26][27] A study from Egypt reported that colorectal cancer patients had higher serum organochlorines levels than controls. 28 Other studies of farmers 29,30 and pesticide manufacturers, [31][32][33] however, did not show any excess risk of colorectal cancer.…”

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confidence: 99%

Pesticide use and colorectal cancer risk in the agricultural health study

Lee

Sandler

Blair

et al. 2007

Intl Journal of Cancer

121

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We investigated the relationship between agricultural pesticides and colorectal cancer incidence in the Agricultural Health Study. A total of 56,813 pesticide applicators with no prior history of colorectal cancer were included in this analysis. Detailed pesticide exposure and other information were obtained from self-administered questionnaires completed at the time of enrollment (1993)(1994)(1995)(1996)(1997). Cancer incidence was determined through populationbased cancer registries from enrollment through December 31, 2002. A total of 305 incident colorectal cancers (212 colon, 93 rectum) were diagnosed during the study period, 1993-2002. Although most of the 50 pesticides studied were not associated with colorectal cancer risk, chlorpyrifos use showed significant exposure response trend (p for trend 5 0.008) for rectal cancer, rising to a 2.7-fold (95% confidence interval: 1.2-6.4) increased risk in the highest exposure category. Aldicarb was associated with a significantly increased risk of colon cancer (p for trend 5 0.001), based on a small number of exposed cases, with the highest exposure category resulting in a 4.1-fold increased risk (95% confidence interval: 1.3-12.8). In contrast, dichlorophenoxyacetic acid showed a significant inverse association with colon cancer but the association was not monotonic. Our findings should be interpreted cautiously since the literature suggesting that pesticides are related to colorectal cancer is limited. Nonetheless the possibility of an association between exposure to certain pesticides and incidence of colorectal cancer among pesticide applicators deserves further evaluation. ' 2007 Wiley-Liss, Inc.

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Serum Organochlorine Pesticide Levels in Patients with Colorectal Cancer in Egypt

Cited by 65 publications

References 23 publications

Evaluation of organochlorine pesticide residues in human serum from an urban and two rural populations in Portugal

Evaluation of organochlorine pesticide residues in human serum from an urban and two rural populations in Portugal

Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt

Pesticide use and colorectal cancer risk in the agricultural health study

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