Serum Osteocalcin Level Is Associated with Glucose Metabolism and Atherosclerosis Parameters in Type 2 Diabetes Mellitus

Kanazawa, Ippei; Yamaguchi, Toru; Yamamoto, Masahiro; Yamauchi, Mika; Kurioka, Soichi; Yano, Shozo; Sugimoto, Toshitsugu

doi:10.1210/jc.2008-1455

Cited by 386 publications

(309 citation statements)

References 27 publications

Supporting

Mentioning

259

Contrasting

Unclassified

Order By: Relevance

“…demonstrated an inverse correlation between higher levels of osteocalcin and mar kers of atherosclerosis (lower ankle-brachial in- dex and increased intima-media thickness), suggesting that osteocalcin might be implicated in the atherosclerotic disease (28). Other observational study in 102 patients younger than 40 years old identified a negative association between osteocalcin levels and acute myocardial infarction (29).…”

Section: Osteocalcin Levels and Metabolic Parameters In Humansmentioning

confidence: 96%

Osteocalcin, energy and glucose metabolism

Zanatta

Boguszewski

Borba

et al. 2014

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on pancreatic beta cells and adipose tissue. Undercarboxylated osteocalcin is the hormonally active isoform and stimulates insulin secretion and enhances insulin sensitivity in adipose tissue and muscle. Insulin and leptin, in turn, act on bone tissue, modulating the osteocalcin secretion, in a traditional feedback mechanism that places the skeleton as a true endocrine organ. Further studies are required to elucidate the role of osteocalcin in the regulation of glucose and energy metabolism in humans and its potential therapeutic implications in diabetes, obesity and metabolic syndrome. Arq Bras Endocrinol Metab. 2014;58(5):444-51 Keywords Osteocalcin; undercarboxylated osteocalcin; metabolic syndrome; glucose; energy metabolism; diabetes; obesity; leptin; insulin; adiponectin RESUMO A osteocalcina é uma proteína da matriz óssea que tem sido implicada com várias ações hormonais relacionadas à homeostase de glicose e ao metabolismo energéti-co. Modelos animais e experimentais têm demonstrado que a osteocalcina é liberada do osso para a circulação sanguínea e age nas células betapancreáticas e no tecido adiposo. A osteocalcina decarboxilada é a isoforma hormonalmente ativa e estimula a secreção e sensibilidade à insulina no tecido adiposo e muscular. A insulina e a leptina, por sua vez, atuam no tecido ósseo modulando a secreção da osteocalcina, formando uma alça de retroalimentação tradicional em que o esqueleto torna-se um órgão endócrino. Novos estudos ainda são necessários para elucidar o papel da osteocalcina na regulação glicêmica e no metabolismo energético em humanos, com potenciais implicações terapêuticas no tratamento de diabetes, obesidade e síndrome metabólica. Arq Bras Endocrinol Metab. 2014;58(5):444-51 Descritores

show abstract

Section: Osteocalcin Levels and Metabolic Parameters In Humansmentioning

confidence: 96%

Osteocalcin, energy and glucose metabolism

Zanatta

Boguszewski

Borba

et al. 2014

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…Indeed, levels of circulating osteocalcin have been inversely correlated with BMI, fat mass and plasma glucose levels in adult or elderly men and women of diverse ethnicities [26][27][28][29]. Additional studies have linked low osteocalcin to impaired levels of HbA 1c , fasting insulin and insulin resistance (estimated by the HOMA of insulin resistance HOMA-IR) in adult men and women, irrespective of whether they have diabetes [28,[30][31][32][33]. In contrast, serum osteocalcin has been positively correlated with the HOMA of beta cell function (HOMA-%B) in diabetic patients, before and after glycaemic control [33,34].…”

Section: Clinical Relevance Of the Osteocalcin-mediated Regulation Ofmentioning

confidence: 99%

“…Levels of circulating osteocalcin have also been associated with a number of lipid abnormalities. For instance, serum osteocalcin levels are inversely correlated with levels of adipocyte-specific fatty acid-binding protein (A-FABP) in a mixed population, and with levels of HDL-cholesterol in men, and are positively correlated with total adiponectin levels in post-menopausal women [27,31,34]. In addition, an association of decreased levels of osteocalcin with premature myocardial infarction in young patients or with coronary heart disease in older individuals have been reported [34,36].…”

Section: Clinical Relevance Of the Osteocalcin-mediated Regulation Ofmentioning

confidence: 99%

The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism

2011

View full text Add to dashboard Cite

Bone remodelling, which maintains bone mass constant during adulthood, is an energy-demanding process. This, together with the observation that the adipocyte-derived hormone leptin is a major inhibitor of bone remodelling, led to the hypothesis that bone cells regulate energy metabolism through an endocrine mechanism. Studies to test this hypothesis identified osteocalcin, a hormone secreted by osteoblasts, as a positive regulator of insulin secretion, insulin resistance and energy expenditure. Remarkably, insulin signalling in osteoblasts is a positive regulator of osteocalcin production and activation via its ability to indirectly enhance bone resorption by osteoclasts. In contrast, leptin is a potent inhibitor of osteocalcin function through its effect on the sympathetic tone. Hence, osteocalcin is part of a complex signalling network between bone and the organs more classically associated with the regulation of energy homeostasis, such as the pancreas and adipose tissue. This review summarises the molecular and cellular bases of the present knowledge on osteocalcin biology and discusses the potential relevance of osteocalcin to human metabolism and pathology.

show abstract

“…There is accumulating evidence that OC is also involved in glucose metabolism and insulin secretion (Oz et al 2006;Pedrazzoni et al 1989). Serum OC has been shown to be negatively correlated with (a) the degree of glucose intolerance (Bouillon et al 1995), (b) with fasting glucose in patients with diabetes and with homeostasis model assessment of insulin resistance (HOMA-IR; Kanazawa et al 2009), and (c) with systolic blood pressure in hypertensive postmenopausal women. Since there is sufficient evidence for a link between serum OC levels with metabolic syndrome and cardiovascular risk factors, OC should be considered not only a bone turnover marker but also an index of general health.…”

Section: Biochemical and Endocrine Serum Markersmentioning

confidence: 99%

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

Karasik

2010

AGE

View full text Add to dashboard Cite

Genetic study can provide insight into the biologic mechanisms underlying inter-individual differences in susceptibility to (or resistance to) organisms' aging. Recent advances in molecular genetics and genetic epidemiology provide the necessary tools to perform a study of the genetic sources of biological aging. However, to be successful, the genetic study of a complex condition requires a heritable phenotype to be developed and validated. Genome-wide association studies offer an unbiased approach to identify new candidate genes for human diseases. It is hypothesized that convergent results from multiple aging-related traits will point out the genes responsible for the general aging of the organism. This perspective focuses on the musculoskeletal aging as an example of an approach to identify a downstream common pathway that summarizes aging processes. Since the musculoskeletal traits are linked to the state of many vital functions, disability, and ultimately survival rates, we postulate that there is significance in studying musculoskeletal aging. Construction of an integrated phenotype of aging can be achieved based on shared genetics among multiple musculoskeletal biomarkers. Valid biomarkers from other systems of the organism should be similarly explored. The new composite aging score needs to be validated by determining whether it predicts all-cause mortality, incidences of major chronic diseases, and disability late in life. Comprehensive databases on biomarkers of musculoskeletal aging in multiple large cohort studies, along with information on various health outcomes, are needed to validate the proposed measure of biological aging.

show abstract

Serum Osteocalcin Level Is Associated with Glucose Metabolism and Atherosclerosis Parameters in Type 2 Diabetes Mellitus

Abstract: Serum osteocalcin is associated with glucose and total adiponectin levels, fat mass, and atherosclerosis parameters in patients with type 2 diabetes, suggesting that osteocalcin is important for not only bone metabolism but also glucose and fat metabolism.

Cited by 386 publications

References 27 publications

Osteocalcin, energy and glucose metabolism

Osteocalcin, energy and glucose metabolism

The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

Contact Info

Product

Resources

About