Serum osteocalcin levels are useful as a predictor of cardiovascular events in maintenance hemodialysis patients

Yamashita, Tetsuri; Okano, Kazuhiro; Tsuruta, Yuki; Akiba, Takashi; Nitta, Kosaku

doi:10.1007/s11255-012-0156-6

Cited by 19 publications

(20 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the association between an increased serum osteocalcin level and a decreased cardiometabolic risk, to date only a few longitudinal follow-up studies have investigated the effects of osteocalcin on the development of CVD. In a longitudinal observational cohort study conducted among 126 hemodialysis patients, a lower median level of serum osteocalcin was significantly associated with the development of CVD after adjusting for age, sex, time of hemodialysis, previous history of CVD, presence of diabetes and the serum calcium X phosphate product and parathyroid hormone levels over a period of five years (HR, 2.925; 95% CI, 1048-9.066; p 0.04) 24) . However, another longitudinal study reported somewhat contrary results; all-cause and cardiovascular mortality was highest in the subjects in the highest total osteocalcin quintile among elderly men during a median 5.2-year follow-up 17) .…”

Section: Resultsmentioning

confidence: 99%

Association between the Circulating Total Osteocalcin Level and the Development of Cardiovascular Disease in Middle-aged Men: A Mean 8.7-year Longitudinal Follow-up Study

Hwang

Kang

Cho

et al. 2015

J Atheroscler Thromb

View full text Add to dashboard Cite

Aim: Recent studies have suggested that the serum osteocalcin level is associated with various cardiovascular risk factors. The aim of this study was to determine whether the serum total osteocalcin level is associated with the development of cardiovascular disease (CVD). Methods: A total of 1,290 men 40-78 years of age were enrolled. The subjects were followed regularly at the Health Promotion Center on an outpatient basis and during hospitalization for a mean of 8.7 years, and the incidence of CVD (coronary heart disease [CHD] and stroke) was determined. Results: At baseline, the body mass index, body fat percentage, fasting glucose, homeostasis model assessment-insulin resistance, triglyceride and non-high density lipoprotein (HDL) cholesterol levels were inversely and the HDL cholesterol levels were positively associated with the serum osteocalcin levels. In addition, the prevalence of diabetes or metabolic syndrome decreased as the osteocalcin tertile increased. However, no differences were observed in the prevalence of hypertension across the osteocalcin tertiles. Incident CVD occurred in 74 (5.7%) of the study subjects (29 patients with CHD and 47 patients with stroke). According to the Cox proportional hazards models, however, there were no statistical differences in the development of stroke, CHD or CVD across the osteocalcin tertiles after adjusting for other risk factors for CVD, including age, body mass index, current smoking, low-density lipoprotein cholesterol, diabetes, hypertension and the serum creatinine level. Conclusion: In conclusion, the serum total osteocalcin level was not associated with the development of CVD after adjusting for other risk factors for CVD in this cohort.J Atheroscler Thromb, 2015; 22:136-143.

show abstract

Section: Resultsmentioning

confidence: 99%

Association between the Circulating Total Osteocalcin Level and the Development of Cardiovascular Disease in Middle-aged Men: A Mean 8.7-year Longitudinal Follow-up Study

Hwang

Kang

Cho

et al. 2015

J Atheroscler Thromb

View full text Add to dashboard Cite

show abstract

“…A positive association was also found between serum OC and prevalence of coronary heart disease (CHD) in a crosssectional study of 78 patients with type 2 diabetes mellitus (32). By contrast, inverse associations showing an increased risk of CVD events at low serum OC levels were found in hemodialysis patients (19) and in young survivors of myocardial infarction (18). A cross-sectional study in patients who underwent coronary angiography found a linear negative relationship between serum OC and CHD prevalence (17).…”

Section: Discussionmentioning

confidence: 97%

“…While some patient studies have demonstrated inverse associations between circulating OC and CVD (17,18,19), a large cohort study in community-dwelling older men aged 70-89 years found the highest CVD mortality at a high serum OC concentration (20).…”

Section: Introductionmentioning

confidence: 99%

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

Holvik

Schoor

Eekhoff

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: The role of osteocalcin (OC) in cardiovascular disease (CVD) is unresolved. We aimed to study the association between plasma OC concentrations and the risk of non-fatal and fatal CVDs. We also aimed to investigate whether such an association, if present, would be mediated by established metabolic risk factors. Design: A population-based longitudinal cohort study. Methods: In 1995/1996, OC was determined in blood samples drawn from 1319 subjects aged 65-88 years participating in the Longitudinal Aging Study Amsterdam in 1995/1996. The self-reported CVD events were collected every 3 years until 2005/2006, and CVD deaths until 1st January 2007. Cox proportional hazards regression was performed, considering potential confounders (smoking, physical activity, and BMI) and mediators (blood pressure, plasma triglycerides, total and HDL cholesterol, fructosamine, and aortic calcification). Results: During the median 4.1 years follow-up, 709 subjects (53.8%) suffered a CVD event. There was no overall association between OC and CVD: hazard ratio (HR) was 0.97 (95% CI 0.90-1.04) per nmol/l higher plasma OC, adjusted for age and sex. There was a statistical interaction between plasma OC, age, and sex on CVD (PZ0.014). In those subjects aged R75 years, age-adjusted HRs (95% CI) were 0.86 (0.75-0.99) in men and 1.16 (1.03-1.31) in women per nmol/l higher plasma OC. Adjustment for covariates only slightly attenuated the association in older-old men, but did not affect the association in older-old women. Conclusion: A higher plasma OC concentration was associated with a reduced risk of CVD in older-old men and with an increased risk of CVD in older-old women. We found no evidence that this was mediated by arterial calcification or metabolic risk factors.

show abstract

“…Serum osteocalcin level is a significant, independent prognostic factor for cardiovascular disease in dialyzed patients. Yamashita et al [8] investigated the impact of serum osteocalcin on the emergence of new cardiovascular events in hemodialyzed patients. They revealed that the number of cumulative cardiovascular events in the low serum osteocalcin group was significantly higher than that in the high serum osteocalcin group.…”

Section: Discussionmentioning

confidence: 99%

Relationship between aortic pulse wave velocity, selected proinflammatory cytokines, and vascular calcification parameters in peritoneal dialysis patients

Krzanowski

Janda²,

Dumnicka³

et al. 2014

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

Serum osteocalcin levels are useful as a predictor of cardiovascular events in maintenance hemodialysis patients

Cited by 19 publications

References 28 publications

Association between the Circulating Total Osteocalcin Level and the Development of Cardiovascular Disease in Middle-aged Men: A Mean 8.7-year Longitudinal Follow-up Study

Association between the Circulating Total Osteocalcin Level and the Development of Cardiovascular Disease in Middle-aged Men: A Mean 8.7-year Longitudinal Follow-up Study

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

Relationship between aortic pulse wave velocity, selected proinflammatory cytokines, and vascular calcification parameters in peritoneal dialysis patients

Contact Info

Product

Resources

About