1998
DOI: 10.2169/internalmedicine.37.581
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Serum Paraoxonase Activity and Genotype Distribution in Japanese Patients with Diabetes Mellitus.

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Cited by 52 publications
(17 citation statements)
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“…In contrast to most studies in Caucasians, all our subjects were Japanese undergoing coronary angiography to evaluate CAD without taking lipid-lowering drugs. In the analysis of the PON1 genotype in diabetic patients, one study demonstrated increased intima-media thickness (IMT) on carotid artery echogram in the Q/Q genotype (37), which is consistent with our results, but the other study showed no association between the IMT and PON1 genotypes (38). Another possibility related to factors affecting the antioxidant activity of PON1 is smoking.…”
Section: Discussionsupporting
confidence: 89%
“…In contrast to most studies in Caucasians, all our subjects were Japanese undergoing coronary angiography to evaluate CAD without taking lipid-lowering drugs. In the analysis of the PON1 genotype in diabetic patients, one study demonstrated increased intima-media thickness (IMT) on carotid artery echogram in the Q/Q genotype (37), which is consistent with our results, but the other study showed no association between the IMT and PON1 genotypes (38). Another possibility related to factors affecting the antioxidant activity of PON1 is smoking.…”
Section: Discussionsupporting
confidence: 89%
“…Both methylenetetrahydrofolate reductase (C677T) polymorphism causing Ala-toVal substitution and paraoxonase (Gln192Arg) polymorphism have been reported to show a positive association with carotid IMT (17,18). However, recent studies showed a negative result (19,20), so it remains unclear whether these genotypes can influence carotid IMT.…”
Section: Discussionmentioning
confidence: 99%
“…PON1 catalyzes the breakdown of organophosphates (Jakubowski, 2000;Josse et al, 2001) and also hydrolyzes homocysteine thio-lactone, which can harm some proteins by homocysteinylation. Reduced PON1 activities have been reported in cardiovascular diseases (McElveen et al, 1986;Navab et al, 1997), diabetes mellitus (Abbott et al, 1995;Mackness et al, 1998;Sakai et al, 1998), chronic renal failure (Dantoine et al, 1998), rheumatoid arthritis (Baskol et al, 2005), hyperthyroidism (Raiszadeh et al, 2004), age-related macular degeneration (Baskol et al, 2006) and in cataract (Hashim and Zarina, 2007).…”
Section: Introductionmentioning
confidence: 99%