Serum Phosphorus and Progression of CKD and Mortality: A Meta-analysis of Cohort Studies

Da, Jingjing; Xie, Xinfang; Wolf, Myles; Disthabanchong, Sinee; Wang, Jinwei; Zha, Yan; Lv, Jicheng; Zhang, Luxia; Wang, Haiyan

doi:10.1053/j.ajkd.2015.01.009

Cited by 130 publications

(96 citation statements)

References 34 publications

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“…In addition, SHPT is associated with a faster rate of CKD progression [36]. The meta-analysis suggested that every 1 mg/dL increase in serum Pi was independently associated with an increased risk for kidney failure (HR 1.36; 95% CI 1.20–1.55) [37]. An increased phosphate load can result in tubular injury, interstitial fibrosis, endothelial dysfunction, and vascular calcification via the direct effect of either phosphate or calciprotein particles [38].…”

Section: Discussionmentioning

confidence: 99%

Dietary Changes Involving Bifidobacterium longum and Other Nutrients Delays Chronic Kidney Disease Progression

et al. 2018

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Background: Recent studies suggest that prebiotic and/or probiotic treatments ameliorate kidney function in humans and animals by improving the gut environment. However, the gut microbiota and kidney disease interactions remain to be determined. This study investigated whether synbiotics modulate the gut microbiota and ameliorate kidney function using a rat model of chronic kidney disease (CKD). As uremic toxins are associated with CKD-related mineral and bone disorder, the secondary aim was to evaluate the relationship between synbiotics and secondary hyperparathyroidism (SHPT). Methods: 5/6 nephrectomy (Nx) rats were developed as the CKD model. Sham-operated (sham) rats were used as the control. To investigate the effectiveness of prebiotics (glutamine, dietary fiber, and oligosaccharide) and probiotics (Bifidobacterium longum strain; GFOB diet), rats were randomly assigned to 4 groups: Nx group fed the GFOB diet (n = 10); Nx group fed the control (CON) diet (n = 10); sham group fed the GFOB diet (n = 5); and sham group fed the control diet (n = 5). Blood, feces, and kidney samples were collected and analyzed. Results: Serum creatinine (Cre) and blood urea nitrogen in the Nx GFOB group were significantly lower than those in the Nx CON group. Serum indoxyl sulfate in the Nx GFOB group was lower than that in the Nx CON group, and significantly correlated with serum Cre. Inorganic phosphorus and intact parathyroid hormone in the Nx GFOB group were significantly lower than those in the Nx CON group. Conclusion: Improving the gut environment using synbiotics ameliorated kidney function and might be a pharmacological treatment for SHPT without any serious adverse events.

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Section: Discussionmentioning

confidence: 99%

Dietary Changes Involving Bifidobacterium longum and Other Nutrients Delays Chronic Kidney Disease Progression

et al. 2018

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“…Large cohort studies have consistently shown that hyperphosphatemia is associated with vascular calcification [71], CKD progression [72] and increased risk of cardiovascular events and mortality [73,74,75]. In a 2015 meta-analysis of 12 cohort studies of non-dialysis CKD patients (n = 25,500), an independent association of hyperphosphatemia and risk of CKD progression and mortality was observed [76]. Collectively, the association of serum phosphorus with cardiovascular events and mortality begins at a high normal range of phosphorus [77,78,79] and occurs in patients at all stages of CKD [80,81], as well as in critically ill patients with dialysis-requiring acute kidney injury [75].…”

Section: Derangements Of Bone Mineral Metabolismmentioning

confidence: 99%

Electrolyte and Acid-Base Disorders in Chronic Kidney Disease and End-Stage Kidney Failure

Dhondup

Qian²

2017

Blood Purif

155

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The kidneys play a pivotal role in the regulation of electrolyte and acid-base balance. With progressive loss of kidney function, derangements in electrolytes and acid-base inevitably occur and contribute to poor patient outcomes. As chronic kidney disease (CKD) has become a worldwide epidemic, medical providers are increasingly confronted with such problems. Adequate diagnosis and treatment will minimize complications and can potentially be lifesaving. In this review, we discuss the current understanding of the disease process, clinical presentation, diagnosis and treatment strategies, integrating up-to-date knowledge in the field. Although electrolyte and acid-base derangements are significant causes of morbidity and mortality in CKD and end-stage renal disease patients, they can be effectively managed through a timely institution of combined preventive measures and pharmacological therapy. Exciting advances and several upcoming outcome trials will provide further information to guide treatment and improve patient outcomes.

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“…Epidemiological studies have shown that one of the major causes of increased morbidity and mortality in this group of patients are the disturbances of the calcium-phosphate metabolism. 1 Diet is a key factor that determines both calcium-phosphate balance and nutritional status in hemodialysis (HD) patients, and is an essential component of the therapeutic approach in this population. 2 The primary role of diet in the non-dialysis stage of chronic kidney disease (CKD) is to reduce uremic toxemia and to diminish the risk of developing renal osteodystrophy and hyperkalemia.…”

Section: Introductionmentioning

confidence: 99%

Nutrient intake assessed with Diet History Questionnaire II, in relation to long-term calcium-phosphate control in hemodialysis patients with end-stage renal failure

Wyskida¹,

Wajda²,

Klein³

et al. 2018

Adv Clin Exp Med

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Serum Phosphorus and Progression of CKD and Mortality: A Meta-analysis of Cohort Studies

Cited by 130 publications

References 34 publications

Dietary Changes Involving <b><i>Bifidobacterium</i></b> <b><i>longum</i></b> and Other Nutrients Delays Chronic Kidney Disease Progression

Dietary Changes Involving <b><i>Bifidobacterium</i></b> <b><i>longum</i></b> and Other Nutrients Delays Chronic Kidney Disease Progression

Electrolyte and Acid-Base Disorders in Chronic Kidney Disease and End-Stage Kidney Failure

Nutrient intake assessed with Diet History Questionnaire II, in relation to long-term calcium-phosphate control in hemodialysis patients with end-stage renal failure

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