Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents: The Kobe study

Kubota, Yoshimi; Higashiyama, Aya; Imano, Hironori; Sugiyama, Daisuke; Kawamura, Kuniko; Kadota, Aya; Nishimura, Kunihiro; Miyamatsu, Naomi; Miyamoto, Yoshihiro; Okamura, Tomonori

doi:10.1007/s12603-015-0496-x

Cited by 4 publications

(4 citation statements)

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“…We found a strong negative correlation between serum n-6 and n-3 PUFA and the markers of inflammation (ESR, CRP). The negative relationship between serum n-3 PUFA compositions and correlating CRP level in adults has been reported by other authors [ 48 , 49 ]. Pirschon et al [ 45 ] in a large population found an inverse relationship between an intake of n-3 PUFA and CRP levels, as well as a strong inverse association between high n-6 intake and soluble tumor necrosis factor receptors 1 and 2.…”

Section: Discussionsupporting

confidence: 79%

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity

et al. 2017

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We investigated the association between dietary intake of n-3 and n-6 polyunsaturated fatty acids (PUFAs), serum profiles, and immune and inflammatory markers in juvenile idiopathic arthritis (JIA) in relation to onset, activity, and duration. A total of 66 JIA patients and 42 controls were included. Serum PUFA levels were assessed by gas-liquid chromatography-mass spectrometry, a dietary intake by 7-day dietary record method, and IL-6, IL-10, and IL-17A levels using ELISA. Dietary PUFA intake did not differ between the JIA group and controls. Intakes of n-6 and n-3 PUFA and serum levels were not associated. Levels of total n-6 PUFA and linoleic acid (LA) were higher in inactive JIA than in active JIA. Patients with active and short-lasting disease (less than 3 months from diagnosis) had significantly lower levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) than the control. Serum α-linolenic acid (ALA) levels were significantly higher in poly-JIA than in oligo-JIA and in controls. We found significantly higher serum IL-10 levels in JIA than in controls. Serum n-6 and n-3 levels were significantly negatively correlated with active joint count, erythrocyte sedimentation rate, and C-reactive protein and positively with platelet count. Our study presents the low levels of AA and DHA in the active phase of short-lasting JIA, particularly poly-JIA, and the relationship between n-6 and n-3 PUFA and classic markers of inflammation. PUFAs may contribute to the pathogenesis of JIA and support a necessity to identify new targets suitable for successful interventional studies in JIA patients.

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Section: Discussionsupporting

confidence: 79%

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity

et al. 2017

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“…Data collection for other characteristics at the follow-up survey was conducted in accordance with the baseline survey of the KOBE study [4][5][6][7]10]. Similar questionnaires were modified for the CI patients.…”

Section: Data Collectionmentioning

confidence: 99%

Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-Sectional Study

et al. 2019

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Background: While water intake is frequently recommended to prevent cerebral infarction (CI), only few studies have been published on this topic. Objectives: This study retrospectively estimated the daily non-alcohol drink (NAD) intake in CI patients before CI onset and compared it with NAD in healthy subjects. Methods: We performed a cross-sectional study on CI patients in 3 hospitals and healthy subjects in the Kobe Orthopedic and Biomedical Epidemiologic (KOBE) study. Data from 1,287 subjects (274 CI patients and 1,013 healthy subjects) were used for the analyses. By dividing the CI patients into “increased”, “unchanged”, and “decreased” groups according to their current NAD intake, we compared the NAD intake between these 3 groups and healthy subjects by analyses of covariance and the post hoc test, adjusting for sex, age, surveyed month, body mass index, alcohol drinking history, and smoking history. Under the assumption that the NAD intake in the “unchanged” group was equal to the NAD intake before CI onset, the OR of less NAD intake for CI adjusting for the relevant variables in the “unchanged” group and the healthy subjects was calculated; the cut-off point was chosen using Youden’s index. Results: The mean age (mean ± SD) of the participants was 62.8 ± 9.3 years. One hundred and fifty-one patients (36 women) were included in the “increased” group; 105 (30 women), in the “unchanged” group; 18 (2 women), in the “decreased” group; and 1,013 (706 women), in the “healthy” group. The mean NAD intake was 1,702.5 ± 670.2 mL in the “increased” group, 1,494.2 ± 611.2 mL in the “unchanged” group, 1,268.0 ± 596.1 mL in the “decreased” group, and 1,720.6 ± 686.0 mL in the “healthy” group. After adjusting for the relevant variables, a significant difference in NAD intake between the groups was observed (F = 6.1, p < 0.001), and a post hoc test demonstrated significant differences (p < 0.05) in NAD intake between the “healthy” and “unchanged” groups, and between the “increased” and “unchanged” groups. The OR of less NAD intake (<1,570 mL/day, chosen using Youden’s index) for CI was 2.48 (95% CI 1.52–4.07). Conclusion: This study showed that daily NAD intake before CI onset in CI patients was less than that in healthy persons, indicating that sufficient intake of NAD may be protective for CI.

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“…Subjects with a low intake of omega-3 fatty acids had higher levels of CRP and vice versa [29]. A similar study by Kubota et al (2015) comparing serum levels of FUFA (polyunsaturated fatty acid) and hs-CRP levels in a healthy Japanese population found that serum omega-3 and serum omega-6 levels had an inverse relationship to serum hs-CRP levels [30]. Different research results were reported by Flock et al (2014), who found that EPA and DHA supplementation with varying doses of 300, 600, 900, and 1800 mg/d for five mo in healthy adults had no effect on levels of the inflammatory biomarker CRP, TNF-α and IL-6 [31].…”

Section: Hs-crp Levelsmentioning

confidence: 91%

Efficacy of Catfish (Pangasius Hypophthalmus) Oil to Overcome Stunting by Reducing Inflammatory Condition

Reski

Mundhofir

Murbawani

et al. 2021

Int J Pharm Pharm Sci

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Objective: This study aimed to evaluate the effect of catfish (Pangasius hypophthalmus) oil on hs-CRP and transthyretin levels of undernourished Wistar rats. Methods: Thirty male Wistar rats were divided into five equal groups. Healthy control (KN) is normal rats that consumed a standard diet only and negative control (K-) is undernourished rats that consumed a protein-free diet only. Undernourished rats that consumed a protein free diet and catfish (Pangasius hypophthalmus) oil at doses 0.020 ml/200 g-body-weight/d, 0.040 ml/200 g-body-weight/d and 0.060 ml/200 g-body-weight/d were classified to P1, P2 and P3 groups, respectively. Hs-CRP is a parameter to evaluate inflammatory condition. Transthyretin and body weight are parameters for measuring nutritional status. Results: Treatment of catfish (Pangasius hypophthalmus) oil on P3 group significantly increases body weight of rats (p<0.05) compare to K-, P1 and P2 groups. There were significant difference of hs-CRP levels in P1, P2 and P3 groups (p<0.05) compare to K-. Hs-CRP levels in P1, P2 and P3 groups compared lower to K-but higher than KN. The mean value of hs-CRP levels in the P3 group (dose 0.060 ml/200 g-body-weight/d) was lower than the other treatment groups. Otherwise, there were no significant difference of TTR levels in P1, P2 and P3 group (p>0.05) compared to K-. Conclusion: The present study showed that catfish (Pangasius hypophthalmus) oil has the potential effect to increase body weight and reduce inflammatory biomarker (hs-CRP) levels but has no effect to increase TTR levels in undernourished Wistar rats.

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Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents: The Kobe study

Abstract: Patients with AD that received DBS of the nucleus basalis of Meynert demonstrated a mainly stable nutritional status within a 1-year period. Whether DBS is causative regarding these observations must be investigated in additional studies.

Cited by 4 publications

References 40 publications

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity

Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-Sectional Study

Efficacy of Catfish (Pangasius Hypophthalmus) Oil to Overcome Stunting by Reducing Inflammatory Condition

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