Serum procalcitonin levels in chronic hepatitis C patients under pegylated interferon-alpha plus ribavirin treatment

Elefsiniotis, Ioannis; Petrocheilou, Aikaterini; Scarmeas, Nikolaos; Ketikoglou, I.; Pantazis, Konstantinos; Toutouza, Marina; Tsianos, Epameinondas V.

doi:10.1016/j.jcv.2006.08.014

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…184 Interestingly, this is not seen in the same amount as in cirrhotic patients in the ICU. 185 Serum procalcitonin levels seem to be a useful marker of infection in decompensated cirrhotic patients 186 ; data regarding ALF patients are scarce.…”

Section: Problems In Diagnosis Of Infectionmentioning

confidence: 99%

Infectious Complications of Acute and Chronic Liver Disease

Leber

Spindelboeck

Stadlbauer

2012

Semin Respir Crit Care Med

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Acute and chronic liver diseases are frequently complicated by infections, which result in increased morbidity and mortality and place an economic burden on health care systems. This review discusses the epidemiology and the impact on prognosis of infections in liver cirrhosis, nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, acute liver failure, and post-liver transplantation. Possible mechanisms for this increased susceptibility are innate immune dysfunction (Kupffer cells, neutrophils, monocytes), genetic predisposition, and intrinsic cellular defects. The causes for innate immune dysfunction may lie in increased gut permeability, the occurrence of endotoxemia, albumin and lipoprotein dysfunction, or toll-like receptor expression. From a clinical viewpoint this article discusses problems in diagnosing infection. Established (vaccination, antibiotic prophylaxis, antiviral prophylaxis, and nutrition) and experimental (probiotic) prophylactic strategies as well as established (antibiotics) and experimental (liver support, albumin, toll-like receptor antagonists) strategies are also reviewed.

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Section: Problems In Diagnosis Of Infectionmentioning

confidence: 99%

Infectious Complications of Acute and Chronic Liver Disease

Leber

Spindelboeck

Stadlbauer

2012

Semin Respir Crit Care Med

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“…For surgical patients with pre-existing liver diseases or scheduled for hepatectomy, PCT could also be valuable in anticipating surgical outcomes. Patients with liver disease, especially cirrhosis, are prone to bacterial infection, thus early diagnosis of infection in patients with underlying liver diseases is necessary ( Elefsiniotis et al, 2006 ). Besides, in 2 days after abdominal surgery, the value of PCT is increased due to bile leakage of residual liver, causing abdominal bacteria pollution, which may lead to local or systemic infections ( Meisner et al, 1998 ; Jekarl et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients

Meng

Zong

et al. 2021

Front. Pharmacol.

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Objectives: Procalcitonin (PCT) has long been proved as an early diagnostic signal for postoperative outcomes. The purpose of this study is to explore the value of serum procalcitonin levels in predicting post-hepatectomy liver failure (PHLF), and further to declarethe relationship between postoperative PCT and short-term prognosis in patients after hepatectomy.Methods: Clinical data of patients with hepatocellular carcinoma (HCC) who underwent hepatectomy from June 1st, 2019 to September 31st, 2020 at Shanghai Eastern Hepatobiliary Surgery Hospital had been retrospectively analyzed. Logistic regression analysis was used to evaluate the risk factors related to PHLF. The Kaplan-Meier method was used to calculate the PHLF rate and 30-day survival after surgery.Results: A total of 885 patients with complete data were finally included in analysis, 311 of them with elevated serum PCT (≥1 ng/ml). Results of the logistic regression analysis suggested a significant association between PCT and PHLF [HR, 95%CI; 3.801 (1.825, 7.917), p < 0.001]. Other significant risk factors for PHLF included portal hypertension, portal blocking time (>30 min) and blood transfusion (>200 ml). Kaplan-Meier analysis also suggested a higher PHLF rate in elevated PCT patients [9.0% (95% CI, 7.3 to 12.8 VS. 1.9% (95% CI, 1.1–4.3)); p < 0.001]. For secondary outcomes, elevated PCT was also highly associated with postoperative sepsis, ICU admission, 30-day mortality and 3-month mortality.Conclusion: Elevated procalcitonin level in patients after hepatectomy is related to higher PHLF rate, with lower 30-day survival and poor short-term postoperative outcomes.

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“…Oruc et al [15] reported that serum PCT levels were within normal ranges in both steatohepatitis and steatosis patients, although serum CRP levels were reported to be elevated in steatohepatitis patients and in severely obese patients with diabetes [8]. Elefsinoitis et al [9] reported that serum PCT levels in chronic hepatitis C patients under INF-α plus Ribavirin treatment remained within normal limits (< 0.5 ng/mL), although serum PCT levels slightly declined within the normal range in sustained virological responders. Elefsiniotis et al [31] also reported that acute alcoholic hepatitis with a cirrhotic background as well as acute viral hepatitis with chronic liver disease without proved bacterial infection induces mild elevation of serum PCT levels (> 0.5 ng/mL).…”

Section: Pct Levels In Other Liver Diseasesmentioning

confidence: 99%

“…In bacterial infections such as SBP in LC patients, renal impairment is one of the prognostic factors, and type-1 hepatorenal syndrome is associated with a particularly poor prognosis [6,7]. On the contrary, the prevalence of infections caused by multidrug-resistant bacteria has increased in patients with LC in recent years [8,9]. Moreover, a delay in the diagnosis of a bacterial infection is often fatal in LC patients [10].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Bacterial Peritonitis and Procalcitonin Levels in the Serum and Ascites of Liver Cirrhosis Patients

Shizuma

2014

JGPLD

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The onset of SBP and bacteremia in LC patients occurs due to changes in the composition of the intestinal bacterial flora, breakdown of the intestinal mucosal barrier because of gastrointestinal bleeding, or the translocation of pathological bacterial from the intestine to mesenteric lymph nodes [20,21]. Bacterial translocation is reportedly common among patients with LC and severe liver dysfunction [21,22]. Bacteremia develops more frequently among patients who undergo catheterization or endoscopic procedures and in those who experience gastrointestinal bleeding [5].

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Serum procalcitonin levels in chronic hepatitis C patients under pegylated interferon-alpha plus ribavirin treatment

Cited by 6 publications

References 4 publications

Infectious Complications of Acute and Chronic Liver Disease

Infectious Complications of Acute and Chronic Liver Disease

Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients

Spontaneous Bacterial Peritonitis and Procalcitonin Levels in the Serum and Ascites of Liver Cirrhosis Patients

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