Serum prolidase activity and oxidative–antioxidative status in Legg–Calve–Perthes disease

Abstract

We aimed to find out that whether collagen turnover is altered in the context of Legg-Calve-Perthes disease (LCPD) by evaluating serum prolidase activity. We also investigated the correlation between collagen turnover and oxidative-antioxidative status in LCPD. Plasma prolidase activity, total oxidant status (TOS), total antioxidant capacity, and oxidative stress index (OSI) were determined for 39 patients with LCPD and 40 healthy controls. Serum prolidase activity, TOS, and OSI were higher, but TAC was lower in patients with LCPD compared with controls. Prolidase activity was positively correlated with TOS and OSI levels. Serum prolidase activity is significantly associated with LCPD.

Serum prolidase activity and oxidative–antioxidative status in patients with developmental dysplasia of the hip and its relationship with radiographic severity

“…Although prolidase activity is found in a wide variety of diseases, reports have been contradictory. Several studies have reported that prolidase activity decreases in diseases such as osteoarthritis, 5 uraemic bone disease, 6 and osteogenesis imperfecta, 7 while increased prolidase activity has been described in Legg-Calve-Perthes disease 8 and idiopathic clubfoot. 4 In the current study, the increased serum prolidase levels in patients with DDH compared to controls may be a marker of increased collagen turnover and may be responsible for the altered histological structure of the joint capsule and other soft tissues.…”

“…4,8,9,28 In the current study, we evaluated oxidative/antioxidative status. With respect to an increase in oxidative stress, our findings concurred with those of previous studies.…”

“…Studies on osteoarthritis, 5 ureamic bone disease, 6 and osteogenesis imperfecta 7 have shown decreased levels of prolidase activity. However, studies of Legg-Calve-Perthes disease 8 and idiopathic clubfoot 4 have found elevated levels of prolidase activity. In these disorders, a relationship has shown between the serum prolidase concentration, disease activity, and/or bone metabolism.…”

“…5 The association of oxidative-antioxidative status parameters and serum prolidase activity has been investigated in several studies. 4,8 These studies showed that collagen metabolism may be related to oxidative stress, and this association may have a role in the aetiopathogenesis and/or severity of the disease. In this study, we hypothesis that serum prolidase activity and oxidative stress may be associated with severity of DDH.…”

Doğuştan çarpık ayak etiyolojisi

“…Serum prolidaz aktivitesi ile oksidatif durum ilişkisinin incelendiği birçok çalışmada, kollajen metabolizması-nın oksidatif stres durumuyla ilişkili olduğu ve bu iliş-kinin etiyopatogenezde ve/veya hastalığın ilerleyişinde etkili olabileceği düşünülmüştür. [12,13] Bu mantıkla dü-zenlenen bir çalışmada, serum prolidaz aktivitesinin ve oksidatif stresin idiyopatik PEV ile ilişkili olabileceği ileri sürülmüştür. Prolidaz aktivitesi ile oksidatif ve antioksidatif parametreler beraberce incelenmiştir.…”