Serum Protein Effects on Polarization Behavior of 316L Stainless Steel

Abstract

This investigation examined the effects of serum proteins addition on the anodic and cathodic polarization behavior of implant alloy316L stainless steel in saline. Cyclic anodic potentiodynamic polarization was used to determine the four critical parameters associated with passive film breakdown and repassivation: corrosion potential, pitting potential, repassivation potential, and reverse scan hysteresis. Cathodic potentiodynamic polarization was used to study the effects of serum proteins on the Tafel slope and limiting current density of the reduction reaction. Three different conditions of solution purging were investigated. Resu/ts were compared with in vivo (hamster) tests. The corrosion potential was significantly affected by aeration conditions in saline as well as in 10% serum. The pitting potential was shifted marginally in the positive direction by serum proteins. While proteins did not affect the cathodic reduction mechanism, their adsorption decreased the reduction kinetics.KEY WORDS: implant, in vitro, in vivo, orthopaedic, protein, serum, stainless steel.

Corrosion behavior of bulk amorphous and crystalline Zr‐based alloys in simulated body fluid with and without additions of protein

“…When a material is introduced into the body, the first step is a rapid adsorption of plasma proteins on the material surface, which affects the corrosion behavior and metal release of the material. However, in general there is a lack of consensus whether biomolecules accelerate or inhibit electrochemical corrosion . Enhancement of dissolution rate in the presence of proteins can be explained by the formation of complexes between metal ions and proteins which facilitate detachment of metal ions from the surface .…”

Cast Co-Cr alloy and pure chromium in proteinaceous media: an electrochemical characterization

“…Some published papers I- [5][6][7][8] show that the inclusion of proteins in standard in vitro test solutions is important for the determination of the corrosion resistance of metals and alloys. Nevertheless, further work must be performed in order to answer the questions raised, such as which particular proteins influence the process, at which conditions and concentrations, is corrosion enhanced or inhibited, how differently do materials behave, what happens to the surface, what kind of corrosion products are generated and what is the actual mechanism by which proteins interfere in the degradation of metallic medical devices?…”

Corrosion behavior of metallic materials in biomedical applications. II. Stainless steels and Co-Cr alloys

“…(Reprinted from Corrosion Science, Copyright 1969, with permission from Elsevier.) rate (Brown & Merritt, 1980, 1981bChawla, Brown, Merritt, & Payer, 1990;Hansen, 2007;Kocijan, Milosev, & Pihlar, 2003;Tang, Katsuma, Fujimoto, & Hiromoto, 2006). A combination of albumin and fibrinogen was reported to increase i corr of 316L stainless steel in Hanks solution by an order of magnitude (Hansen, 2007).…”