Serum Renalase Depends on Kidney Function But Not on Blood Pressure in Heart Transplant Recipients

Przybyłowski, Piotr; Małyszko, Jolanta; Kozlowska, S.; Koc-Żórawska, Ewa; Myśliwiec, M

doi:10.1016/j.transproceed.2011.08.075

Cited by 53 publications

(50 citation statements)

References 15 publications

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“…These results agreed to a recent study, which showed the role of renalase in the degradation of catecholamine and the regulation of BP and cardiovascular function, in addition to its relationship with renal function biomarkers [9]. In contrast, many recent studies concluded that the elevated renalase levels in hemodialysis patients may be due to impaired renal function only [24][25][26]. There are contradictory data about serum renalase because of low activity and high levels revealed in hypertensive patients with CKD [27].…”

Section: Resultssupporting

confidence: 92%

The Possible Role of Renalase Enzyme in Cardiovascular Complications in Chronic Kidney Disease Patients

Al-Shamma

2018

Asian J Pharm Clin Res

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Objective: The objective of this research was to study the possible role of renalase in the controlling blood pressure (BP) in patients with different stages of chronic kidney diseases (CKD) to decrease the incidents of cardiovascular disease in these patients. Methods:The serum levels of renalase were determined by enzyme-linked immune sorbent assay (ELISA) methods in 68 non-diabetic CKD patients in different stages (2-5). Fifty healthy control subjects were included in this study. Renalase high-sensitive C-reactive protein and Cystatin-C were measured by ELISA which is included first incubating the test serum in an antigen-coated polystyrene plate, then enzyme-labeled anti-immunoglobulin is added and the enzyme then remaining in plate after washing provides a measure of the amount of specific antibody in the serum, and in the final step, a substance is added that the enzyme can convert to some detectable signal, most commonly a color change in a chemical substrate.Results: There were a significant difference between serum levels of renalase, in CKD patients stage 5, and CKD patients 2-3 stage than in their healthy control group (p<0.05), in addition to a significant difference in renalase level between CKD stage, 2-3 and stage 5 (p<0.05). There was a significant positive correlation between serum renalase with systolic BP (p<0.05) in CKD patients stage 5. In addition, there was a significant negative correlation between the serum renalase and estimated glomerular filtration rate (p<0.05) in both groups. Conclusions:The main conclusion of the study was the positive significant correlation with systolic BP in CKD patients (stage 5). In addition, the serum renalase levels were elevated according the CKD stage in patients with CKD in different stages (2-5) and it increased with the deterioration of renal function.

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Section: Resultssupporting

confidence: 92%

The Possible Role of Renalase Enzyme in Cardiovascular Complications in Chronic Kidney Disease Patients

Al-Shamma

2018

Asian J Pharm Clin Res

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“…Moreover, the involvement of renalase in the modulation of the catecholaminergic system has become increasingly clear. Thus, human renalase is now regarded as a new player in the control of blood pressure and heart function, whose modulation could lead to promising new pharmacological treatments of various cardiovascular dysfunctions [3,8,13,23,24,70,71].…”

Section: Discussionmentioning

confidence: 99%

“…A renalase concentration of 0.1 mg per gram wet tissue has been estimated in the kidneys by immunoblotting [10]. Data on the absolute concentration of renalase in human blood plasma have been explicitly reported only recently, as determined by ELISA, showing that it is about 4 g/ml in healthy individuals, corresponding to 0.1 M [23][24][25][26][27][28]. Murine renalase gene expression was observed by reverse transcriptase PCR in kidney, testicle, liver, heart, 12.5-days whole embryo, brain, and skeletal muscle [16].…”

Section: Renalase Isoforms and Gene Expression Patternmentioning

confidence: 99%

“…Recent studies on the impact of kidney and heart transplantation on the level of circulating renalase led to the unexpected finding that plasma renalase concentration increases after organ implantation and the degree of increase correlates with the severity of kidney failure in the allograft recipients [23][24][25].…”

Section: Nadph-dependent Diaphorase Reactions With Various Artificialmentioning

confidence: 99%

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Is Renalase a Novel Player in Catecholaminergic Signaling? The Mystery of the Catalytic Activity of an Intriguing New Flavoenzyme

Baroni¹,

Milani²,

Pandini³

et al. 2013

CPD

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Renalase is a flavoprotein recently discovered in humans, preferentially expressed in the proximal tubules of the kidney and secreted in blood and urine. It is highly conserved in vertebrates, with homologs identified in eukaryotic and prokaryotic organisms. Several genetic, epidemiological, clinical and experimental studies show that renalase plays a role in the modulation of the functions of the cardiovascular system, being particularly active in decreasing the catecholaminergic tone, in lowering blood pressure and in exerting a protective action against myocardial ischemic damage. Deficient renalase synthesis might be the cause of the high occurrence of hypertension and adverse cardiac events in kidney disease patients. Very recently, recombinant human renalase has been structurally and functionally characterized in vitro. Results show that it belongs to the p-hydroxybenzoate hydroxylase structural family of flavoenzymes, contains non-covalently bound FAD with redox features suggestive of a dehydrogenase activity, and is not a catecholamine-degrading enzyme, either through oxidase or NAD(P)H-dependent monooxygenase reactions. The biochemical data now available will hopefully provide the basis for a systematic and rational quest toward the identification of the reaction catalyzed by renalase and of the molecular mechanism of its physiological action, which in turn are expected to favor the development of novel therapeutic tools for the treatment of kidney and cardiovascular diseases.

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“…There are few clinical studies considering renalase concentration in patients with heart failure. Przybylowski et al [33] observed higher serum renalase concentration in heart transplant recipients compared to healthy volunteers, but the serum creatinine level appeared to a predictor of renalase concentration. There was no correlation between serum renalase and hypertension nor the presence of diabetes [33].…”

Section: Renalase and Cvdmentioning

confidence: 96%

Renalase — a new marker or just a bystander in cardiovascular disease: clinical and experimental data

Musiałowska

Małyszko

2016

Kardiol Pol

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Serum Renalase Depends on Kidney Function But Not on Blood Pressure in Heart Transplant Recipients

Cited by 53 publications

References 15 publications

The Possible Role of Renalase Enzyme in Cardiovascular Complications in Chronic Kidney Disease Patients

The Possible Role of Renalase Enzyme in Cardiovascular Complications in Chronic Kidney Disease Patients

Is Renalase a Novel Player in Catecholaminergic Signaling? The Mystery of the Catalytic Activity of an Intriguing New Flavoenzyme

Renalase — a new marker or just a bystander in cardiovascular disease: clinical and experimental data

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