Serum resistin concentrations in growth hormone–deficient children during growth hormone replacement therapy

Nozue, Hiroki; Kamoda, Tomohiro; Matsui, Akira

doi:10.1016/j.metabol.2007.06.018

Cited by 11 publications

(15 citation statements)

References 27 publications

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“…Our data are in agreement with some studies that have documented that GH treatment does not seem able to strongly modify resistin levels in GHD adults [10,20], although we found a trend to an increase in resistin levels after 12 months, though not statistically significant. Partially in line with our results, Nozue et al [21] demonstrated a rise in resistin after short-term GH therapy in GHD children, while López-Siguero et al [12] showed a decline in resistin at 6 months of GH treatment and these data are in line with those of Meazza et al [19] who showed a decrease in resistin levels. However, despite the lack of a statistically significant change, the trend to an increase in resistin in our patients during GH treatment is concomitant with a significant reduction in insulin sensitivity, as demonstrated by the decline in QUICKI and ISI Matsuda, in line with previous studies.…”

Section: Discussionsupporting

confidence: 92%

Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children

Ciresi

Pizzolanti

Leotta

et al. 2016

J Endocrinol Invest

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Section: Discussionsupporting

confidence: 92%

Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children

Ciresi

Pizzolanti

Leotta

et al. 2016

J Endocrinol Invest

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“…In contrast to the study performed by Willemsen et al [19], they reported that IGF-1 and resistin levels increased significantly after treatment with GH [20]. Schmid et al detected that T4 replacement increased IGF-1 level in primary and central hypothyroid patients [21].…”

Section: Discussionmentioning

confidence: 93%

“…In another study performed with children having GH deficiency, Nozue et al investigated effect of GH treatment on serum resistin levels [20]. In contrast to the study performed by Willemsen et al [19], they reported that IGF-1 and resistin levels increased significantly after treatment with GH [20].…”

Section: Discussionmentioning

confidence: 99%

Serum Resistin and Insulin-Like Growth Factor-1 Levels in Patients with Hypothyroidism and Hyperthyroidism

Koyuncu

Yildirmak

Temizel

et al. 2013

Journal of Thyroid Research

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Introduction. The aim of this study was to evaluate the serum levels of resistin and insulin-like growth factor-1 (IGF-1) and and also the potential relationship between thyroid function and levels of resistin and IGF-1 in hypothyroid and hyperthyroid patients. Methods. Fifteen cases of hypothyroid (HT), 16 of subclinically hypothyroid (SCHT), 15 of hyperthyroid (HrT), 15 of subclinically hyperthyroid (SCHrT), and 17 healthy individuals have been included in the study. Serum resistin levels were measured using enzyme-linked immunosorbent assay and IGF-1 and thyroid stimulating hormone (TSH) levels by chemiluminescence method. Results. Resistin levels in total HT group were significantly higher than in controls (12.66 ± 6.04 and 8.45 ± 2.90 ng/mL, resp.). In SCHrT subgroup resistin levels were significantly higher than those of controls (14.88 ± 7.73 and 8.45 ± 2.90 ng/mL, resp.). IGF-1 levels were significantly lower in total HT than in total HrT and control groups (117.22 ± 52.03, 155.17 ± 51.67, and 184.00 ± 49.73 ng/mL, resp.). Furthermore IGF-1 levels in HT subgroup were significantly lower compared to controls (123.70 ± 44.03 and 184 ± 49.73 ng/mL, resp.). In SCHT subgroup IGF-1 levels were significantly lower than those of control and SCHrT groups (111.11 ± 59.35, 184.00 ± 49.73, and 166.60 ± 47.87 ng/mL, resp.). There were significant correlations between IGF-1 and TSH in HT subgroup and between resistin and TSH in total HrT group. Conclusion. It was concluded that increased resistin levels are directly related to thyroid dysfunction, and GH/IGF-1 axis is influenced in clinically or subclinically hypothyroidism patients.

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“…However, the regulation of GH receptor expression in the adipose tissue of early lactation dairy cows is unclear [38], [39]. In rodents or human, GH increases resistin gene expression in white adipose tissue or serum resistin levels [40], [41]. Thus, we can hypothesis that resistin could participate to the in vivo GH effects on the adipose tissue of dairy cows.…”

Section: Discussionmentioning

confidence: 99%

Resistin in Dairy Cows: Plasma Concentrations during Early Lactation, Expression and Potential Role in Adipose Tissue

et al. 2014

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Resistin is an adipokine that has been implicated in energy metabolism regulation in rodents but has been little studied in dairy cows. We determined plasma resistin concentrations in early lactation in dairy cows and investigated the levels of resistin mRNA and protein in adipose tissue and the phosphorylation of several components of insulin signaling pathways one week post partum (1 WPP) and at five months of gestation (5 MG). We detected resistin in mature bovine adipocytes and investigated the effect of recombinant bovine resistin on lipolysis in bovine adipose tissue explants. ELISA showed that plasma resistin concentration was low before calving, subsequently increasing and reaching a peak at 1 WPP, decreasing steadily thereafter to reach pre-calving levels at 6 WPP. Plasma resistin concentration was significantly positively correlated with plasma non esterified fatty acid (NEFA) levels and negatively with milk yield, dry matter intake and energy balance between WPP1 to WPP22. We showed, by quantitative RT-PCR and western blotting, that resistin mRNA and protein levels in adipose tissue were higher at WPP1 than at 5 MG. The level of phosphorylation of several early and downstream insulin signaling components (IRβ, IRS-1, IRS-2, Akt, MAPK ERK1/2, P70S6K and S6) in adipose tissue was also lower at 1 WPP than at 5 MG. Finally, we showed that recombinant bovine resistin increased the release of glycerol and mRNA levels for ATGL (adipose triglyceride lipase) and HSL (hormone-sensitive lipase) in adipose tissue explants. Overall, resistin levels were high in the plasma and adipose tissue and were positively correlated with NEFA levels after calving. Resistin is expressed in bovine mature adipocytes and promotes lipid mobilization in adipose explants in vitro.

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Serum resistin concentrations in growth hormone–deficient children during growth hormone replacement therapy

Cited by 11 publications

References 27 publications

Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children

Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children

Serum Resistin and Insulin-Like Growth Factor-1 Levels in Patients with Hypothyroidism and Hyperthyroidism

Resistin in Dairy Cows: Plasma Concentrations during Early Lactation, Expression and Potential Role in Adipose Tissue

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