Serum selenium levels in chronic lymphocytic leukemia

Azarm, Taleb; Fazilati, Mohamad; Hoda, Azarm; Azarm, Arezo

doi:10.4103/2277-9175.114177

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…The first hypothesis states that enhanced uptake of selenium by the neoplastic tissue might be responsible for depleting the trace element content in the blood and other tissues. Thereby, serum selenium concentrations are reduced (24). Secondly, the reduced Se concentration with disease progression might be due to dietary changes (10,24).…”

Section: Discussionmentioning

confidence: 99%

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Selenium status in blood, urine, and hair samples of newly diagnosed pediatric cancer patients

Karaman¹,

Mansuroğlu²,

Kızılbey³

et al. 2015

Turk J Med Sci

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Background/aim: Selenium (Se) is a trace element that has multiple functions. Low Se amounts in serum and hair have been reported in pediatric and adult cancer patients. The aim of our study was to evaluate Se levels in the serum, urine, and hair of pediatric cancer patients with leukemia, lymphoma, and solid tumors when compared with healthy children. Materials and methods:The concentrations of Se in the serum, hair, and urine of 32 Turkish children as healthy controls and 88 Turkish children diagnosed with acute leukemia (58), lymphoma (16), and solid tumors (14) were measured using inductively coupled plasma mass spectroscopy.Results: Se levels in the serum and hair of the children with cancer were significantly lower than those of the controls. There were no differences between the leukemia, lymphoma, and solid tumors group. On the other hand, the Se levels of the urine samples were slightly elevated in cancer patients compared with the control group. There was no marked difference in the Se levels of patients with different types of cancer. Conclusion:Se deficiency might be associated with the development of pediatric cancer. Especially in children, additional studies are needed to define whether low levels of Se may play a role in cancer pathogenesis.

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Section: Discussionmentioning

confidence: 99%

“…Thereby, serum selenium concentrations are reduced (24). Secondly, the reduced Se concentration with disease progression might be due to dietary changes (10,24).…”

Section: Discussionmentioning

confidence: 99%

Selenium status in blood, urine, and hair samples of newly diagnosed pediatric cancer patients

Karaman¹,

Mansuroğlu²,

Kızılbey³

et al. 2015

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…A causal inverse relationship between selenium and haematological malignancies exist (Azarm, Fazilati, Azarm & Azarm, 2013; Cai et al, 2016). An early clinical study reported a decrease in total leukocyte counts, immature leukocytes, and spleen size upon oral administration of selenium cystine (diseleno - dialanine) in patients with both CML and AML (Weisberger & Suhrland, 1956).…”

Section: Selenium-dependent Effects On Cancer Stem Cells In Leukemiamentioning

confidence: 99%

The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium

Diwakar

Korwar

Paulson

et al. 2017

Advances in Cancer Research

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Cancer is a complex disease where cancer stem cells (CSCs) maintain unlimited replicative potential, but evade chemotherapy drugs through cellular quiescence. CSCs are able to give rise to bulk tumor cells that have the capability to override anti-proliferative signals and evade apoptosis. Numerous pathways are dysregulated in tumor cells, where increased levels of pro-oxidant reactive oxygen and nitrogen species (RONS) can lead to localized inflammation to exacerbate all three stages of tumorigenesis: initiation, progression, and metastasis. Modulation of cellular metabolism in tumor cells as well as immune cells in the tumor microenvironment (TME) can impact inflammatory networks. Altering these pathways can potentially serve as a portal for therapy. It is well known that selenium, through selenoproteins, modulates inflammatory pathways in addition to regulating redox homeostasis in cells. Therefore, selenium has the potential to impact the interaction between tumor cells, cancer stem cells, and immune cells. In the sections below, we review the current status of knowledge regarding this interaction, with reference to leukemia stem cells (LSCs), and the importance of selenium-dependent regulation of inflammation as a potential mechanism to affect the TME and tumor cell survival.

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Evaluation of Serum Trace Element and Vitamin Levels in Children With Cancer in the First 6 Months After Diagnosis

Gökçebay

Emir

Bayhan

et al. 2018

Journal of Pediatric Hematology/Oncology

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Adequate nutrient intake should be provided for the cure of children diagnosed with cancer. The aim of this study was to evaluate serum trace elements and vitamins of children with cancer at diagnosis and during treatment. Children with newly diagnosed cancer who were admitted to our center were evaluated for serum selenium, iron, ferritin, C-reactive protein, vitamin B12, folate, and 25-OH vitamin D levels at presentation, and at the third and sixth months of cancer treatment. Forty-two children (male/female: 15/27) with a median age of 8 years (range, 2 to 17) were included in the study. Mean serum B12, folate, and iron levels were within normal ranges, but selenium and 25-OH vitamin D were low at presentation and during the 6-month period. Serum ferritin levels were high in all 3 measures, but they decreased significantly at the sixth month (P=0.04). There was no relation between micronutrient deficiency and sex, or primary disease, or stage, or place of residence of the patient. In conclusion, serum trace element and vitamin deficiencies are common in children with cancer, and there is a need for further studies with larger patient series.

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Serum selenium levels in chronic lymphocytic leukemia

Cited by 4 publications

References 15 publications

Selenium status in blood, urine, and hair samples of newly diagnosed pediatric cancer patients

Selenium status in blood, urine, and hair samples of newly diagnosed pediatric cancer patients

The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium

Evaluation of Serum Trace Element and Vitamin Levels in Children With Cancer in the First 6 Months After Diagnosis

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