Serum semicarbazide-sensitive amine oxidase (SSAO) activity is an independent marker of carotid atherosclerosis

Karádi, István; Mészáros, Z.; Csányi, Attila; Szombathy, Tamás; Hosszúfalusi, Nóra; Romics, L; Magyar, K.

doi:10.1016/s0009-8981(02)00189-4

Cited by 55 publications

(34 citation statements)

References 26 publications

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“…36 The weak associations of sVAP-1 to traditional risk factors of CVDs have been reported previously by us and others 7,37 although they are not always seen in smaller cohorts. 35,37,38 Because none of the weak correlations observed in this study was seen among participants with incident MACE, we think that these associations may not be relevant in the pathogenesis of CVDs. Importantly, although sVAP-1 can be induced by certain inflammatory conditions, it does not function as a general marker of inflammation because it shows inverse correlation with CRP, and inclusion of CRP into the Framingham risk model does not affect the predictive power of sVAP-1.…”

Section: Discussionmentioning

confidence: 59%

Soluble Vascular Adhesion Protein-1 Predicts Incident Major Adverse Cardiovascular Events and Improves Reclassification in a Finnish Prospective Cohort Study

Aalto

Havulinna

Jalkanen

et al. 2014

Circ Cardiovasc Genet

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Background-Vascular adhesion protein-1 (VAP-1) associates to subclinical atherosclerotic manifestations in young people, but its association to incident major adverse cardiovascular events (MACEs) and cardiovascular mortality in a general population is not known. Methods and Results-We used a newly developed ELISA to measure soluble VAP-1 (sVAP-1) levels in 2775 participants (mean age, 60 years) from a prospective cohort study (the FINRISK 2002). During a mean follow-up of 9 years, 265 participants underwent a MACE, and these participants had higher levels of sVAP-1 than those without MACE (868 ng/ mL and 824 ng/mL, respectively, P<0.001). In multivariate-adjusted Cox proportional hazard model including traditional Framingham risk factors (age, sex, systolic blood pressure, cholesterol, high-density lipoprotein cholesterol, smoking, prevalent diabetes mellitus, and antihypertensive treatment), sVAP-1 independently predicted incident MACE (P=0.0046) and MACE mortality (P=0.026). The impact of sVAP-1 in predicting the 9-year absolute risk of MACE was analyzed using integrated discrimination improvement and net reclassification improvement with 10-fold cross-validation.

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Section: Discussionmentioning

confidence: 59%

Soluble Vascular Adhesion Protein-1 Predicts Incident Major Adverse Cardiovascular Events and Improves Reclassification in a Finnish Prospective Cohort Study

Aalto

Havulinna

Jalkanen

et al. 2014

Circ Cardiovasc Genet

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“…Earlier, sVAP-1 activity has been reported either to show indirect, 17 direct 21,35,36 or no 19,22,23,37 correlation with BMI. Moreover, in some reports no association between triglycerides and sVAP-1 activity has been seen, 35 whereas others have reported either direct 36 or indirect 38 correlations.…”

Section: Discussionmentioning

confidence: 92%

“…Moreover, in some reports no association between triglycerides and sVAP-1 activity has been seen, 35 whereas others have reported either direct 36 or indirect 38 correlations. We found that sVAP-1 activity showed an indirect correlation with BMI and triglycerides, and (after BMI adjustment) a direct correlation with LDL cholesterol in women.…”

Section: Discussionmentioning

confidence: 97%

Soluble Vascular Adhesion Protein-1 Correlates With Cardiovascular Risk Factors and Early Atherosclerotic Manifestations

Aalto

Maksimow

Juonala

et al. 2012

ATVB

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Objective-Vascular adhesion protein-1 is an endothelial enzyme that regulates leukocyte traffic and contributes to vascular damage in animal models. The relations of soluble vascular adhesion protein-1 (sVAP-1) with cardiovascular risk factors and markers of subclinical atherosclerosis at a population level have not been studied. Key Words: adhesion molecules Ⅲ atherosclerosis Ⅲ epidemiology Ⅲ risk factors M igration of leukocytes from the blood into the vascular wall is important for the pathogenesis of atherosclerosis. 1,2 Adhesion molecules on the endothelial surface guide immigration of blood-borne leukocytes to various tissues, including vascular wall. Expression of many of these endothelial adhesion molecules is induced in inflammation. Most endothelial adhesion molecules are also found in plasma as soluble forms. 3 They are normally formed by shedding of the surface-bound molecules or by expression of alternatively spliced variants. Therefore, considerable interest has risen in the possibility of using soluble adhesion molecules as biomarkers for various inflammatory diseases, including atherosclerosis. 4 Vascular adhesion protein-1 (VAP-1) is an endothelial adhesion molecule involved in leukocyte migration from the blood into sites of inflammation. 5 In contrast to many other adhesion molecules, it is a cell-surface expressed enzyme. It belongs to semicarbazide-sensitive amine oxidases (also known as primary amine oxidases) that harbor oxidase activity in their extracellular domains. 6 VAP-1 oxidatively deaminates primary amines into aldehydes in a reaction that also produces hydrogen peroxide and ammonium. The enzymatic activity of VAP-1 is important for its adhesive function, 7,8 and it also modulates the inflammatory microenvironment through regulation of transcription factors, chemokines, and other adhesion molecules. 9 -11 Nevertheless, the biological end-products of VAP-1 catalyzed reaction are potentially cytotoxic at higher concentrations, and they are implied in the development of different vasculopathies. For instance, the involvement of VAP-1 in the production of endogenous aldehydes, reactive oxygen species, and advanced glycation end products and in the regulation of arterial structure have been proposed to lead to vascular damage in cellular and animal models. [12][13][14][15] A soluble form of VAP-1 (sVAP-1) is normally present in plasma. 16 The level of sVAP-1 is increased in certain inflam- Analyses of animal models and specific diseases thus suggest that VAP-1 may be involved in cardiovascular damage, but this has never been addressed at a population level. Here we developed a new high-throughput method for determining sVAP-1 activity in serum samples and correlated it to different cardiovascular risk factors and markers of subclinical atherosclerosis in a thoroughly characterized cohort of 2183 young Finns. Methods Study Subjects and Serum SamplesThe study cohort was from the Cardiovascular Risk in Young Finns Study. 25 It includes 3596 persons recruited in 1980 who have been exte...

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“…VAP-1 is shed from the hepatic vasculature and adipose tissue, and measurement of VAP-1 levels in hepatic and portal veins suggests that the liver is a major source of sVAP-1 (23,26). Elevated serum sVAP-1 levels have also been reported in patients with diabetes, obesity, and complications of the metabolic syndrome such as atherosclerosis and congestive heart failure (27)(28)(29)(30)(31).…”

Section: Circulating Serum [Svap-1] Is Significantly Elevated In Humamentioning

confidence: 98%

“…Because circulating levels of sVAP-1 are significantly elevated in the serum of patients with chronic inflammatory liver diseases and in those with complications of the metabolic syndrome (23,(26)(27)(28)(29)(30), we investigated whether sVAP-1 levels in patients with the metabolic syndrome are associated with the presence and severity of NAFLD. We compared serum levels of sVAP-1 in 144 patients with biopsy-proven NAFLD and 74 control patients matched for age and metabolic phenotype but without biochemical or radiological evidence of liver disease ( Table 1).…”

Section: Circulating Serum [Svap-1] Is Significantly Elevated In Humamentioning

confidence: 99%

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis

Weston¹,

Shepherd²,

Claridge³

et al. 2014

J. Clin. Invest.

188

205

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Serum semicarbazide-sensitive amine oxidase (SSAO) activity is an independent marker of carotid atherosclerosis

Cited by 55 publications

References 26 publications

Soluble Vascular Adhesion Protein-1 Predicts Incident Major Adverse Cardiovascular Events and Improves Reclassification in a Finnish Prospective Cohort Study

Soluble Vascular Adhesion Protein-1 Predicts Incident Major Adverse Cardiovascular Events and Improves Reclassification in a Finnish Prospective Cohort Study

Soluble Vascular Adhesion Protein-1 Correlates With Cardiovascular Risk Factors and Early Atherosclerotic Manifestations

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis

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