Serum Sialic Acid Levels in Lung Cancer Patients

Krolikowski, F J; Reuter, Kerstin C.; Waalkes, T. Phillip; Sieber, S. M.; Adamson, R. H.

doi:10.1159/000136578

Cited by 45 publications

(18 citation statements)

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“…In cancer, these sialylated conjugates protect malignant cells from cellular defense systems. Elevated levels of NANA have been found in various cancer types, including lung cancer (49). Sialic acid as a blood biomarker for prognosis has been assessed with mixed results, although, to our knowledge, not in lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer

et al. 2014

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Lung cancer remains the most common cause of cancer deaths worldwide, yet there is currently a lack of diagnostic noninvasive biomarkers that could guide treatment decisions. Small molecules (<1500 Da) were measured in urine collected from 469 lung cancer patients and 536 population controls using unbiased liquid chromatography-mass spectrometry. Clinical putative diagnostic and prognostic biomarkers were validated by quantitation and normalized to creatinine levels at two different time points and further validated in an independent sample set, which comprises 80 cases and 78 population controls, with similar demographic and clinical characteristics when compared to the training set. Creatine riboside (IUPAC name: 2-{2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-oxolan-2-yl]-1-methylcarbamimidamido}acetic acid), a novel molecule identified in this study, and N-acetylneuraminic acid (NANA), were each significantly (P <0.00001) elevated in non–small cell lung cancer (NSCLC) and associated with worse prognosis (hazard ratio (HR) =1.81 [P =0.0002], and 1.54 [P =0.025], respectively). Creatine riboside was the strongest classifier of lung cancer status in all and stage I–II cases, important for early detection, and also associated with worse prognosis in stage I–II lung cancer (HR =1.71, P =0.048). All measurements were highly reproducible with intraclass correlation coefficients ranging from 0.82 – 0.99. Both metabolites were significantly (P <0.03) enriched in tumor tissue compared to adjacent non-tumor tissue (N =48), thus revealing their direct association with tumor metabolism. Creatine riboside and NANA may be robust urinary clinical metabolomic markers that are elevated in tumor tissue and associated with early lung cancer diagnosis and worse prognosis.

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Section: Discussionmentioning

confidence: 99%

Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer

et al. 2014

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“…A total of 5639 (21%) men and 3307 (12%) women died during the follow up period, in whom death in 3052 (54%) men and 1368 (41%) women was from cardiovascular causes. During short (0-6 years), medium (7-13 years), and long (14)(15)(16)(17)(18)(19)(20) years) term follow up the relative risk of death from cardiovascular disease increased with increasing serum sialic acid concentration. The relative risk (95% confidence interval) associated with the highest quartile of sialic acid concentration compared with the lowest quartile was 2-38 (2-01 to 2.83) in men and (1-93 to 3.57) in women.…”

Section: Introductionmentioning

confidence: 99%

Serum sialic acid concentration and cardiovascular mortality.

Lindberg¹,

Eklund²,

Gullberg³

et al. 1991

BMJ

207

120

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“…Krolikowski et al (1976) showed that there is a significant difference in the levels of sialic acid in patients with lung cancer compared to normal controls. Hence they reported sialic acid to be of value as a biologic marker in lung cancer [12]. Seber et al (1989) also showed that sialic acid levels in BAL fluid were highly correlated with the diagnosis of bronchial cancer [13].…”

Section: Discussionmentioning

confidence: 99%