Serum sialic acid concentration and cardiovascular mortality.

Lindberg, Gunnar; Eklund, Gunnar; Gullberg, Bo; Råstam, Lennart

doi:10.1136/bmj.302.6769.143

Cited by 207 publications

(134 citation statements)

References 12 publications

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“…However, a few contradictory reports have weaken this contention. Moreover, factors such as aging, pregnancy and smoking may affect sialic acid concentration and sialic acid is not specific for a given disease, thereby limiting its potential clinical usability (1). Serum sialic acid estimation, however, in different racial groups may be useful to assess individual at risk of cardiovascular diseases.…”

Section: Resultsmentioning

confidence: 99%

“…Sporadic reports on serum sialic acid in cardiovascular diseases were published in 70s and 80s but the real interest in serum sialic acid in cardiovascular disease grew only after the report of Lindberg et al (1) who showed that serum sialic acid is a strong predictor of cardiovascular mortality and may also reflect the existence or activity of an atherosclerotic process. Later on, many studies came up showing that serum sialic acids were elevated in cardiovascular diseases (3)(4)(5)(6)(7)(8)(9)(10).…”

Section: Serum Sialic Acidmentioning

confidence: 99%

“…Interest in the role played by sialic acid in the pathogenesis of atherosclerosis and as a predictor of cardiovascular events has rapidly increased in recent years especially since it has been shown to be a strong predictor of both coronary heart disease (CHD) and stroke mortality and reflector of the existence or activity of an atherosclerotic process (1,2). Thereafter, many studies showed that serum sialic acid were elevated in cardiovascular disease (3 -11).…”

Section: Introductionmentioning

confidence: 99%

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Sialic acid in cardiovascular diseases

Nigam

Narain

Kumar

2006

Indian J Clin Biochem

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Sialic acid, the acylated derivatives of 9-carbon sugar neuraminic acid, present as terminal component of oligosaccharide chains of many glycoproteins and glycolipids, has been recognized to be involved in the regulation of a great variety of biological phenomena. Studies have shown that serum sialic acid predicts both coronary heart disease and stroke mortality and reflects the existence or activity of an atherosclerotic process. Most of the studies have shown an elevation in serum sialic acid concentration in coronary heart disease and a positive correlation between the raised serum sialic acid and the severity of the coronary lesions is observed. However, a few contradictory reports are also available. Racial differences in serum sialic acid have also been reported and correlated with international differences in the prevalence of atherosclerosis. Reduced sialic acid content of platelets, erythrocytes and lipoproteins may play important role in the pathogenesis of atherosclerosis. Elucidation of the mechanism of alternation in sialic acid concentration may throw more light on its potential clinical utility. Hence more studies are needed to designate sialic acid as a cardiovascular risk factor / marker.

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Section: Resultsmentioning

confidence: 99%

Section: Serum Sialic Acidmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sialic acid in cardiovascular diseases

Nigam

Narain

Kumar

2006

Indian J Clin Biochem

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“…An elevated serum sialic acid level is a strong predictor of cardiovascular mortality in the general population (2). In type 2 diabetes, the circulating sialic acid concentration is elevated in comparison with nondiabetic subjects (3), especially in those with the metabolic syndrome (4).…”

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confidence: 99%

Relationship Between Plasma Sialic Acid Concentration and Microvascular and Macrovascular Complications in Type 1 Diabetes

Pj³

et al. 2001

Diabetes Care

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The APPENDIX section contains a complete list of centers that participated in the EURODIAB IDDM Complications Study.Abbreviations: AER, albumin excretion rate; CHD, coronary heart disease; CV, coefficient of variation. A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. Relationship Between Plasma Sialic Acid Concentration and Microvascular and Macrovascular Complications in Type 1 DiabetesThe EURODIAB Complications StudyOBJECTIVE -To test the hypothesis that an increased plasma concentration of sialic acid, a marker of the acute-phase response, is related to the presence of diabetic micro-and macrovascular complications in type 1 diabetes. RESEARCH DESIGN AND METHODS -We investigated the relationship betweenplasma sialic acid concentration and nephropathy, retinopathy, neuropathy, and coronary heart disease (CHD) in a cross-sectional survey of 1,369 people with type 1 diabetes. Subjects were participants in the EURODIAB IDDM Complications Study, which involved 31 centers in 16 European countries.RESULTS -There was a significantly increasing trend of plasma sialic acid with severity of retinopathy (P Ͻ 0.001 in men) and with degree of urinary albumin excretion (P Ͻ 0.001 men, P Ͻ 0.01 women). Plasma sialic acid correlated with increasing plasma creatinine concentration (P Ͻ 0.009 men, P Ͻ 0.0002 women), and men with neuropathy had a higher plasma sialic acid concentration than those without (P Ͻ 0.006). There was no significant correlation between plasma sialic acid and CHD in either sex. Elevated plasma sialic acid concentrations were also associated with several risk factors for diabetic vascular disease: diabetes duration, HbA 1c , plasma triglyceride and cholesterol concentrations, waist-to-hip ratio, hypertension and smoking (in men), and low physical exercise (in women). In multiple logistic regression analysis, plasma sialic acid was independently related to proliferative retinopathy and urinary albumin excretion rate in men.CONCLUSIONS -We conclude that an elevated plasma sialic concentration is strongly related to the presence of microvascular complications in type 1 diabetes, especially retinopathy and nephropathy. Further study of acute-phase response markers and mediators as indicators or predictors of diabetic microvascular complications is therefore justified.

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“…A recent prospective study by Lindberg et al (1) revealed that the serum sialic acid concentration can be a strong predictor of high mortality from cardiovascular disease.…”

mentioning

confidence: 99%