J Atheroscler Thromb

1994

DOI: 10.5551/jat1994.1.113

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Serum Sialic Acid Concentration and Atherosclerotic Risk Factors

Ichiro Wakabayashi¹,

Kunihiro Sakamoto²,

Shusuke Yoshimoto³

et al.

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Discussion2

Serum Sialic Acid1

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Cited by 11 publications

(8 citation statements)

References 14 publications

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“…Some earlier studies of SA as a cardiovascular risk factor have shown a positive correlation between serum SA level and markers of inflammation in atherosclerosis [23][24][25]. Some earlier studies of SA as a cardiovascular risk factor have shown a positive correlation between serum SA level and markers of inflammation in atherosclerosis [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Association of serum sialic acid and MMP‐9 with lipids and inflammatory markers

¹

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²

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³

et al. 2000

Eur J Clin Investigation

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Serum sialic acid does not appear to be an indicator of inflammation but is somehow connected with the level of total and HDL cholesterol. Serum matrix metalloproteinase-9 may provide a useful marker of inflammation because it correlates with the leukocyte count and is not associated with the lipid profile.

“…Some earlier studies of SA as a cardiovascular risk factor have shown a positive correlation between serum SA level and markers of inflammation in atherosclerosis [23][24][25]. Some earlier studies of SA as a cardiovascular risk factor have shown a positive correlation between serum SA level and markers of inflammation in atherosclerosis [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Association of serum sialic acid and MMP‐9 with lipids and inflammatory markers

¹

,

²

,

³

et al. 2000

Eur J Clin Investigation

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Serum sialic acid does not appear to be an indicator of inflammation but is somehow connected with the level of total and HDL cholesterol. Serum matrix metalloproteinase-9 may provide a useful marker of inflammation because it correlates with the leukocyte count and is not associated with the lipid profile.

“…Later on, many studies came up showing that serum sialic acids were elevated in cardiovascular diseases (3)(4)(5)(6)(7)(8)(9)(10). Serum sialic acid levels correlated with carotid atherosclerosis, independently of major cardiovascular risk factors (26).…”

Section: Serum Sialic Acidmentioning

confidence: 99%

Sialic acid in cardiovascular diseases

¹

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²

,

³

2006

Indian J Clin Biochem

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Sialic acid, the acylated derivatives of 9-carbon sugar neuraminic acid, present as terminal component of oligosaccharide chains of many glycoproteins and glycolipids, has been recognized to be involved in the regulation of a great variety of biological phenomena. Studies have shown that serum sialic acid predicts both coronary heart disease and stroke mortality and reflects the existence or activity of an atherosclerotic process. Most of the studies have shown an elevation in serum sialic acid concentration in coronary heart disease and a positive correlation between the raised serum sialic acid and the severity of the coronary lesions is observed. However, a few contradictory reports are also available. Racial differences in serum sialic acid have also been reported and correlated with international differences in the prevalence of atherosclerosis. Reduced sialic acid content of platelets, erythrocytes and lipoproteins may play important role in the pathogenesis of atherosclerosis. Elucidation of the mechanism of alternation in sialic acid concentration may throw more light on its potential clinical utility. Hence more studies are needed to designate sialic acid as a cardiovascular risk factor / marker.

“…[2][3][4] Some authors suggest that serum TSA reflects the degree of atherosclerotic progress and that serial measurements of serum TSA levels may be a useful indicator of the progression of CAD. 5,6 In contrast, Salomone et al 7 and Wu et al Some of the studies relating sialic acid to the development of CAD have focused on the relationship between low density lipoprotein (LDL)-associated sialic acid and CAD. 9,10 LDL concentration in plasma is an important predictor for atherosclerosis, and desialylated LDL has been proposed to be particularly atherogenic.…”

Section: Introductionmentioning

confidence: 99%

Sialic acid and oxidizability of lipid and proteins and antioxidant status in patients with coronary artery disease

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²

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³

et al. 2006

Cell Biochemistry & Function

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The aim of this study was to investigate the possible relationship between serum total sialic acid (TSA) concentration, recently shown to be a cardiovascular risk factor, and lipid and protein oxidation and antioxidant status and the severity of coronary artery disease (CAD) according to the obstructive vessel number in patients. The study was carried out on a total of 200 patients (142 men and 58 women) who were hospitalized for elective coronary angiographic evaluation with complaint of typical angina pectoris. According to the results of angiography, 150 patients had angiographically proven CAD (CAD group) and 50 patients had a history suggestive of angina pectoris but normal coronary angiograms (control group). The CAD group was further divided into single-, double- and triple-vessel disease groups according to the number of vessels involved. Lipid parameters were determined by routine laboratory methods. Plasma malondialdehyde (MDA) and vitamin E concentrations were determined by high-performance liquid chromatography. TSA and other oxidant and antioxidant parameters were studied spectrophotometrically. Our results demonstrated significant increases both in TSA levels and in indicators of oxidative stress in the patients with CAD compared with the controls. However, antioxidant parameters were decreased in the patients with CAD. We found strong positive correlations between TSA and plasma MDA, Delta-MDA which represents the degree of oxidative modification of apolipoprotein B-containing lipoproteins, serum protein carbonyls and apolipoprotein B and weak correlations between TSA and low density lipoprotein cholesterol, triacylglycerol, paraoxonase, glutathione peroxidase (GPx), vitamin C and vitamin E. In conclusion, TSA is related to markers of lipid and protein oxidation, paraoxonase and GPx activities, vitamin C and E levels and the severity of CAD.

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