Serum Sickness–Like Reaction in Children Due to Cefditoren

Mısırlıoğlu, Emine Dibek; Duman, Hakan; Özmen, Serap; Bostancı, İlknur

doi:10.1111/j.1525-1470.2011.01539.x

Cited by 12 publications

(9 citation statements)

References 4 publications

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“…8,10,11 Patients may also experience oedema, malaise, myalgia and lympadenopathy; notable laboratory abnormalities may include elevated ESR, CRP and leucocytosis. 12,13 The diagnosis of SSLR in this patient was suggested by several factors including the timing of the onset of symptoms, the classical clinical manifestations and the successful oral ciprofloxacin challenge. Our patient first developed signs of an urticarial rash of the upper head and neck after eight days of MTZ therapy.…”

Section: Details Of the Casementioning

confidence: 94%

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Probable metronidazole induced serum sickness-like reaction in a paediatric patient

et al. 2016

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Section: Details Of the Casementioning

confidence: 94%

“…Joint involvement can be polyarticular and commonly affects the joints of the wrists, hips, knees and ankles . Patients may also experience oedema, malaise, myalgia and lympadenopathy; notable laboratory abnormalities may include elevated ESR, CRP and leucocytosis …”

Section: Details Of the Casementioning

confidence: 99%

Probable metronidazole induced serum sickness-like reaction in a paediatric patient

et al. 2016

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“…Serum sickness reactions and serum sickness‐like reactions are rare and generally occur 2–21 days after the administration of medications containing proteins and infections (serum sickness reaction) or antibiotics (serum sickness‐like reaction). The disease consists of cutaneous eruption, arthralgia/arthritis of the metacarpophalangeal and knee joints and fever, without signs of systemic involvement nor circulating immune complexes or low complement levels . Skin lesions appear as symmetric, erythematous maculo‐papules or urticarial lesions distributed most prominently on the trunk and lower extremities.…”

Section: Febrile Disordersmentioning

confidence: 99%

“…Skin lesions appear as symmetric, erythematous maculo‐papules or urticarial lesions distributed most prominently on the trunk and lower extremities. Other presentations include scarlatiniform or erythema multiforme‐like eruptions . Histology shows densely packed neutrophils in the vessels together with mixed infiltrate of neutrophils, lymphocytes and eosinophils .…”

Section: Febrile Disordersmentioning

confidence: 99%

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Skin rash and arthritis a simplified appraisal of less common associations

Cozzi

Doria

Gisondi

et al. 2013

Acad Dermatol Venereol

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Skin and joint manifestations are part of the clinical spectrum of many disorders. Well-known associations include psoriatic arthritis and arthritis associated with autoimmune connective tissue diseases. This review focuses on less common associations where skin lesions can provide easily accessible and valuable diagnostic clues, and directly lead to the specific diagnosis or limit the list of possibilities. This may also affect health care resources as diagnostic tests are often low-specific, highly expensive and poorly available. This group of diseases can be divided into two subsets, based on the presence/absence of fever, and then further classified according to elementary skin lesions (macular, urticarial, maculo-papular, vesico-bullous, pustular, petechial and nodular). In most instances joint involvement occurs as peripheral migrating polyarthritis. Erythematosus macular or urticarial rashes occur in most febrile disorders such as monogenic autoinflammatory syndromes, Schnitzler's syndrome, Still's disease and rheumatic fever and afebrile diseases as urticarial vasculitis. Pustular rash may be observed in chronic recurrent multifocal osteomyelitis (CRMO) and pyogenic arthritis with pyoderma gangrenosum and acne (PAPA) syndrome (both febrile) as well as in Behcet's disease and Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome (both non-febrile). Papular lesions are typical of secondary syphilis, sarcoidosis, interstitial granulomatous dermatitis, papular petechial of cutaneous small-vessel vasculitis and nodular lesions of polyarteritis nodosa and multicentric reticulohistiocytosis all of which are afebrile. Differential diagnosis includes infections and drug reactions which may mimic several of these conditions. To biopsy the right skin lesion at the right time it is essential to obtain relevant histological information.

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