Serum soluble transferrin receptor concentrations are increased in central obesity. Results from a screening programme for hereditary hemochromatosis in men with hyperferritinemia

Soluble transferrin receptor and risk of type 2 diabetes in the obese and nonobese

“…There is strong evidence that obesity, a chronic low-grade inflammatory condition, increases sTfR concentrations [18][19][20][21][22][23]. There is strong evidence that obesity, a chronic low-grade inflammatory condition, increases sTfR concentrations [18][19][20][21][22][23].…”

“…The authors of this study hypothesised that the sTfR was a biomarker of some other factor, unrelated to iron metabolism, that was causally related to T2DM [7]. Several studies have observed a significantly higher levels of sTfR in obese children [18], adolescents [19], adults [20], pre- [21] and postmenopausal women [22] and even in obese men with hyperferritinaemia [23] than in the respective nonobese groups. Several studies have observed a significantly higher levels of sTfR in obese children [18], adolescents [19], adults [20], pre- [21] and postmenopausal women [22] and even in obese men with hyperferritinaemia [23] than in the respective nonobese groups.…”

“…Curiously, a recognised risk factor for T2DM such as obesity [2] seems to influence sTfR homoeostasis. Several studies have observed a significantly higher levels of sTfR in obese children [18], adolescents [19], adults [20], pre- [21] and postmenopausal women [22] and even in obese men with hyperferritinaemia [23] than in the respective nonobese groups.…”

Iron status in the elderly

“…For example, in a cross-sectional study examining the iron status of 234 obese adults compared with 172 non-obese adults attending an outpatient clinic, the obese patients had a higher prevalence of iron deficiency defined by sTfR and serum iron but not by ferritin (Yanoff et al, 2007). An increase in sTfR was reported to be associated with central obesity in men with hyperferritinemia (Freixenet et al, 2009). Tussing-Humphreys et al (2010) measured serum hepcidin in obese premenopausal women to investigate the reason for iron depletion in obesity.…”

Rethinking Iron Regulation and Assessment in Iron Deficiency, Anemia of Chronic Disease, and Obesity: Introducing Hepcidin

“…Soluble transferrin receptor is less affected by the acute phase response (23) and is therefore considered to be a more useful clinical marker to assess iron status in chronically ill and inflamed individuals. Soluble transferrin receptor can be used to differentiate between ID, the ACD, and conditions in which ID/IDA and the ACD coexist (Table 1) (44, 45). In ID where transferrin receptor expression is increased due to greater cellular iron demand, sTfR concentrations are elevated, whereas in ACD, sTfR is often not elevated due to adequate iron stores (46).…”