Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival

Kitagawa, Yuichiro; Kawamura, Itta; Suzuki, Keiko; Okada, Hideshi; Ishihara, Takuma; Tomita, Hiroyuki; Suzuki, Kodai; Takada, Chihiro; Sampei, So; Kano, Seisuke; Kondo, Kohei; Asano, Hirotaka; Wakayama, Yugo; Kamidani, Ryo; Kawasaki, Yuki; Fukuda, Hirotsugu; Nishio, Ayane; Miyake, Takahito; Fukuta, Tetsuya; Yasuda, Ryu; Oiwa, Hideaki; Kakino, Yoshinori; Miyazaki, Nagisa; Watanabe, Takatomo; Yoshida, Takahiro; Doi, Tomoaki; Suzuki, Akio; Yoshida, Shozo; Matsuo, Hitoshi; Ogura, Shinji

doi:10.1371/journal.pone.0260350

Cited by 9 publications

(3 citation statements)

References 48 publications

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“…The endothelial glycocalyx, a gel-like layer of glycoproteins that covers the luminal surface of the capillary endothelium, is thought to maintain organ and vascular homeostasis ( 7 ). Syndecan-1 (SDC-1), the core protein in heparan sulfate proteoglycan, is found in the endothelial glycocalyx and shed into the blood in various systemic inflammatory conditions, including trauma ( 7 , 8 ), sepsis ( 9 ), acute respiratory distress syndrome ( 10 ), acute kidney injury ( 11 ) and cardiovascular disease ( 12 , 13 ). Additionally, several studies have demonstrated an association between serum SDC-1 level and mortality in trauma patients ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Syndecan-1 as a severity biomarker for patients with trauma

Suzuki

Okada²,

Sumi³

et al. 2022

Front. Med.

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Tissue injury and hemorrhage induced by trauma lead to degradation of the endothelial glycocalyx, causing syndecan-1 (SDC-1) to be shed into the blood. In this study, we investigated whether serum SDC-1 is useful for evaluating trauma severity in patients. A single-center, retrospective, observational study was conducted at Gifu University Hospital. Patients transported to the emergency room for trauma and subsequently admitted to the intensive care unit from January 2019 to December 2021 were enrolled. A linear regression model was constructed to evaluate the association of serum SDC-1 with injury severity score (ISS) and probability of survival (Ps). A total of 76 trauma patients (54 men and 22 women) were analyzed. ISS was significantly associated with serum SDC-1 level in trauma patients. Among the six body regions defined in the AIS used to calculate the ISS score, “chest” and “abdominal or pelvic contents” were significantly associated with serum SDC-1 level, and “extremities or pelvic girdle” also tended to show an association with serum SDC-1 level. Moreover, increasing serum SDC-1 level was significantly correlated with decreasing Ps. Serum SDC-1 may be a useful biomarker for monitoring the severity of trauma in patients. Further large-scale studies are warranted to verify these results.

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Section: Introductionmentioning

confidence: 99%

Syndecan-1 as a severity biomarker for patients with trauma

Suzuki

Okada²,

Sumi³

et al. 2022

Front. Med.

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“…It has also been suggested that syndecan-1 may reflect vascular capacitance load 23 . Conversely, ANP secretion is stimulated by atrial muscle stretch due to atrial pressure, while BNP is secreted when a ventricular load is applied 24 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of the relationship between intradialytic hypotension during hemodialysis and serum syndecan-1 concentration

Oiwa,

Okada,

Suzuki

et al. 2023

Sci Rep

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Intradialytic hypotension and arrhythmias are complications of hemodialysis. They are associated with decreased intravascular volume due to reduced ultrafiltration volume, cardiac function, and arterial tone. The vascular endothelial glycocalyx, which exists on the surface of healthy vascular endothelial cells and maintains vascular permeability, has been suggested to be impaired by hemodialysis. This single-center retrospective study evaluated the association between syndecan-1, an endothelial glycocalyx dysfunction marker, and complications of hemodialysis. We enrolled 92 patients who underwent outpatient hemodialysis at Gifu Seiryu Hospital from April to July 2022 (346 hemodialysis sessions). The median duration and time of hemodialysis were 40 months and 4.1 h, respectively. Median serum syndecan-1 levels were 67.7 ng/mL before and 98.3 ng/mL after hemodialysis. Hemodialysis complications were noted in 68 sessions, all of which were hypotension. No correlation between pre-hemodialysis syndecan-1 levels and the incidence of complications was observed. However, a positive correlation between the amount of change in syndecan-1 levels before and after hemodialysis and the incidence of hemodialysis complications was noted. Conversely, syndecan-1 levels did not correlate with brain or atrial natriuretic peptides, suggesting that impairment of the vascular endothelial glycocalyx may be a possible cause of intradialytic hypotension and may be useful in preventing intradialytic hypotension.

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“…The criticism argues that more event data and tougher criteria are required for strong prediction capability [103]. Furthermore, the discussion emphasizes the necessity of taking into account the interaction between various serum biomarkers and incorporating validated biomarkers for cardiovascular disease when estimating the mortality risk in patients with heart failure, suggesting that a larger dataset is necessary for precise analysis [104,105].…”

Section: Estimation Of Endothelial Glycocalyx Damage In Heart Surgica...mentioning

confidence: 99%

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

Kršek,

Batičić,

Ćurko-Cofek

et al. 2024

CIMB

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The endothelial glycocalyx (EGC) is a layer of proteoglycans (associated with glycosaminoglycans) and glycoproteins, which adsorbs plasma proteins on the luminal surface of endothelial cells. Its main function is to participate in separating the circulating blood from the inner layers of the vessels and the surrounding tissues. Physiologically, the EGC stimulates mechanotransduction, the endothelial charge, thrombocyte adhesion, leukocyte tissue recruitment, and molecule extravasation. Hence, severe impairment of the EGC has been implicated in various pathological conditions, including sepsis, diabetes, chronic kidney disease, inflammatory disorders, hypernatremia, hypervolemia, atherosclerosis, and ischemia/reperfusion injury. Moreover, alterations in EGC have been associated with altered responses to therapeutic interventions in conditions such as cardiovascular diseases. Investigation into the function of the glycocalyx has expanded knowledge about vascular disorders and indicated the need to consider new approaches in the treatment of severe endothelial dysfunction. This review aims to present the current understanding of the molecular mechanisms underlying cardiovascular diseases and to elucidate the impact of heart surgery on EGC dysfunction.

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Serum syndecan-1 concentration in hospitalized patients with heart failure may predict readmission-free survival

Cited by 9 publications

References 48 publications

Syndecan-1 as a severity biomarker for patients with trauma

Syndecan-1 as a severity biomarker for patients with trauma

Investigation of the relationship between intradialytic hypotension during hemodialysis and serum syndecan-1 concentration

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

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