Serum testosterone and dihydrotestosterone changes with age in rat

Ghanadian, R.; Lewis, John G.; Chisholm, G. D.

doi:10.1016/0039-128x(75)90039-2

Cited by 133 publications

(33 citation statements)

References 13 publications

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“…It is, however, only in the 6th post-natal week that androgen-induced stimulation of epididymal secretory activity becomes evident (Hall & Gomes, 1973 ;Gupta et al, 1975), and this is well in advance of sperm entry. A second rise in GPC level between 60-90 days is possibly due to a further increase in the concen¬ tration of androgens in the circulation (Ghanadian, Lewis & Chisholm, 1975) and in the epididymal tissue itself (Calandra et al, 1974). The significant increase in epididymal GPC concentration in the androgen-treated prepubertal rats supports this view, because spermatozoa do not participate in the accumulation of GPC in the epididymis (Dawson & Rowlands, 1959;Brooks et al, 1974).…”

Section: Discussionmentioning

confidence: 96%

Functional maturation of the epididymis in the rat

Setty¹,

Jehan²

1977

Reproduction

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Section: Discussionmentioning

confidence: 96%

Functional maturation of the epididymis in the rat

Setty¹,

Jehan²

1977

Reproduction

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“…The rat is the most popular laboratory animal to examine the effects of aging on testicular androgen synthesis and secretion. A number of studies carried out during the past few decades have led to a clear demonstration that aging leads to significant reduction in blood testosterone levels in several rat strains [157][158][159][160][161][162][163][164][165][166][167][168][169].…”

Section: Experimental Animalsmentioning

confidence: 99%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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“…J., 1975;Lewis et at., 1976). However, the growth and continued function of both benign hyperplasia and carcinoma are dependent on the continued availability of androgens (Huggins & Hodges, 1941;Ghanadian et al, 1975a). Hence the development of these conditions at this particular time appears to be something of a paradox.…”

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confidence: 99%

Serum testosterone and dihydrotestosterone in carcinoma of the prostate

Ghanadian¹,

Puah²,

O'donoghue³

1979

Br J Cancer

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Summary.-Serum testosterone (T) and dihydrotestosterone (DHT) were measured by a sensitive and reliable radioimmunoassay in 42 normal subjects and 33 agematched patients with carcinoma of the prostate. The mean +s.e. for serum testosterone in normal subjects was 16-74h076nM and the corresponding value for patients with carcinoma was 20-94±1-48nM. Statistical analysis of the results showed a significant increase in T level in patients with carcinoma of the prostate (P<001). In contrast, there was no difference in DHT concentration between the two groups, values being 2-43±0-09 and 206±009nM for normal subjects and patients respectively.The means +s.e. for T/DHT ratio in controls and patients were 68+O0-2 and 12-8±1*3 respectively. The difference was highly significant (P<0001). The wide range of variation for T in patients with carcinoma would suggest that although mean T is higher in these patients, this measurement alone is of little practical value, whereas T/DHT ratio is a more reliable parameter in evaluating the androgen changes in these patients. The significance of these findings in relation to the aetiology of the disease is discussed.

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Serum testosterone and dihydrotestosterone changes with age in rat

Cited by 133 publications

References 13 publications

Functional maturation of the epididymis in the rat

Functional maturation of the epididymis in the rat

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Serum testosterone and dihydrotestosterone in carcinoma of the prostate

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