Serum testosterone levels during early pregnancy in patients developing preeclampsia

Tuutti, Eija K; Hämäläinen, Esa; Sainio, Susanna; Hiilesmaa, Vilho; Turpeinen, Ursula; Alfthan, Henrik; Stenman, Ulf‐Håkan

doi:10.3109/00365513.2011.580858

Cited by 16 publications

(10 citation statements)

References 23 publications

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“…This aligns with an older study which showed the free testosterone level in maternal serum remained within range of non-pregnant women until 28 weeks gestation (Bammann, Coulam, & Jiang, 1980). Maternal salivary testosterone levels at each gestational period did not differ by fetal sex, consistent with reports based on maternal serum testosterone in pregnancy (Carlsen et al, 2006;Tuutti et al, 2011;van de Beek et al, 2004). There was also no difference in postpartum maternal salivary testosterone for women who gave birth to boys versus girls.…”

Section: Discussionsupporting

confidence: 89%

“…Maternal salivary testosterone levels at each gestational period did not differ by fetal sex, consistent with reports based on maternal serum testosterone in pregnancy (Carlsen et al, ; Tuutti et al, ; van de Beek et al, ). There was also no difference in postpartum maternal salivary testosterone for women who gave birth to boys versus girls.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Maternal salivary testosterone in pregnancy and fetal neuromaturation

Voegtline¹,

Costigan

DiPietro

2017

Developmental Psychobiology

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Testosterone exposure during pregnancy has been hypothesized as a mechanism for sex differences in brain and behavioral development observed in the postnatal period. The current study documents the natural history of maternal salivary testosterone from 18 weeks gestation of pregnancy to 6 months postpartum, and investigates associations with fetal heart rate, motor activity, and their integration. Findings indicate maternal salivary testosterone increases with advancing gestation though no differences by fetal sex were detected. High intra-individual stability in prenatal testosterone levels extend into the postnatal period, particularly for pregnancies with male fetuses. With respect to fetal development, by 36 weeks gestation higher maternal prenatal salivary testosterone was significantly associated with faster fetal heart rate and less optimal somatic-cardiac integration. Measurement of testosterone in saliva is a useful tool for repeated-measures studies of hormonal concomitants of pregnancy. Moreover, higher maternal testosterone levels are associated with modest interference to fetal neurobehavioral development.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 87%

Maternal salivary testosterone in pregnancy and fetal neuromaturation

Voegtline¹,

Costigan

DiPietro

2017

Developmental Psychobiology

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“…Circulating androgens concentrations increase during normal gestation in women (Berger, Repke, & Woodruff, ; McClamrock & Adashi, ; Mizuno, Lobotsky, Lloyd, Kobayashi, & Murasawa, ; Rivarola, Forest, & Migeon, ) and both, the fetus and the placenta, produce androgens that enter the maternal circulation (Makieva, Saunders, & Norman, ). In pregnant women, circulating maternal serum T is low during the first trimester and increases during gestation (Kerlan, Nahoul, Le Martelot, & Bercovici, ; Makieva et al, ) independent of offspring sex (Troisi et al, ; Tuutti et al, ; van de Beek, van Goozen, Buitelaar, & Cohen‐Kettenis, ).…”

Section: Androgens In Women and Female Cattlementioning

confidence: 99%

“…In pregnant women, circulating maternal serum T is low during the first trimester and increases during gestation (Kerlan, Nahoul, Le Martelot, & Bercovici, 1994;Makieva et al, 2014) independent of offspring sex (Troisi et al, 2003;Tuutti et al, 2011;van de Beek, van Goozen, Buitelaar, & Cohen-Kettenis, 2009).…”

Section: Androgens In Women and Female Cattlementioning

confidence: 99%

Undernutrition and hyperandrogenism during pregnancy: Role in programming of cardiovascular disease and infertility

Mossa

Latham

Ireland

et al. 2019

Molecular Reproduction Devel

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Maternal nutritional status programs the development of several systems in female offspring, with effects that depend on the severity, duration, and window of development when the nutritional perturbation is imposed. On the basis of the developmental origins of health and disease concept, we hypothesize that gestational low caloric intake may induce maternal subclinical hyperandrogenism during early pregnancy and compromise cardiovascular health and fertility in the female offspring. To examine this possibility, a literature search for human and animal studies was conducted using two electronic databases, PubMed and Cochrane until April 2019 to address the following questions: (a) Do androgens have a developmental role in cardiovascular and ovarian development? (b) Is excess maternal testosterone linked to cardiovascular disease and infertility? and (c) Could early pregnancy undernutrition enhance maternal androgen production and compromise health and fertility in female offspring? The observations reviewed, establish a potential causative link between maternal undernutrition and subclinical hyperandrogenism with hypertension and reduced ovarian reserve in the progeny. Further studies in appropriate models are needed to better understand whether low energy intake and subclinical maternal hyperandrogenism during early pregnancy can negatively affect the health of the female offspring.

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“…Male spontaneously hypertensive rats (SHR), which exhibit some signs of a programming model such as smaller size at birth when compared to Wistar-Kyoto control rats, exhibit androgendependent increases in blood pressure and albuminuria that are independent of renal cortical angiotensin II levels and oxidative stress (Sullivan et al, 2007). In contrast, a female specific form of hypertension during pregnancy, preeclampsia, is reportedly not to be influenced by the levels of circulating testosterone levels during pregnancy (Tuutti et al, 2011). Interestingly, the cardio-renal protective effects of estrogens has not been a universal finding (Salazar et al, 2008).…”

Section: Sex Steroidsmentioning

confidence: 99%