Serum thymidine activity and insulin-like growth factors in the neonatal period

Schimpff, R M; Boiocchi, Mauro; Zapf, J.; Repellin, A. M.; Einschenk, I.

doi:10.1530/acta.0.1100140

Cited by 4 publications

(4 citation statements)

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“…Our finding of low levels of IGF-I in newborns compared to adults are in agreement with previous reports by us [9] and others [26]. The findings of increased levels of IGF-I in cord serum from infants of diabetic mothers is of interest.…”

Section: Effects Of Pregnancy and Diabetes On Igf-h Levelssupporting

confidence: 93%

Insulin-like growth factors (IGF) I and II in diabetic pregnancy: Suppression of normal pregnancy-induced rise of IGF-I

1986

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The concentrations of somatomedins/insulin-like growth factors were measured by a specific radioimmunoassay for insulin-like growth factor-I and a specific radioreceptor assay for insulin-like growth factor-II in sera of term normal and Type 1 (insulin-dependent) diabetic pregnant women and in various cord sera of their newborn infants. Serum insulin-like growth factor-I levels in normal (non-diabetic) maternal serum were higher than in non-pregnant women (486 +/- 26 versus 215 +/- 26 ng/ml). The normal pregnancy-induced increment of insulin-like growth factor-I was markedly reduced in diabetic pregnancy. It was not different in patients with good or poor glycaemic control, as judged by normal or elevated blood levels of haemoglobin A1c content. Insulin-like growth factor-I levels in cord serum of infants of diabetic women with good glycaemic control (86 +/- 11 ng/ml) and poor glycaemic control (91 +/- 19 ng/ml) were significantly higher (p less than 0.01) than in infants of non-diabetic women (43 +/- 42 ng/ml). The fetal birth weight ratios were not significantly correlated with insulin-like growth factor-I levels in cord serum. Serum insulin-like growth factor-II levels in maternal and cord serum in diabetic and normal pregnancy were not different from each other or from normal non-pregnant women. The increment in insulin-like growth factor-I levels in maternal serum in pregnancy may influence placental structure and function. Lack of this increment in maternal diabetes may have direct implication in placental abnormalities in diabetes and indirect implications on fetal development and metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Effects Of Pregnancy and Diabetes On Igf-h Levelssupporting

confidence: 93%

Insulin-like growth factors (IGF) I and II in diabetic pregnancy: Suppression of normal pregnancy-induced rise of IGF-I

1986

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“…Liver and serum IGF-I in fetal rats correlated with fetal weight in growth retardation produced by uterine artery ligation (35). Recent studies have shown divergence patterns of thymidine uptake stimulating activity from immunoassable IGF-I concentration in blood of human fetuses at gestational ages from 2 1-28 wk (36) and cord blood of human neonates (37) suggesting that factors other than IGF contributing to thymidine activity may also play a role in fetal growth.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Glucocorticoids on Plasma Insulin-Like Growth Factor I Concentration in the Rat Fetus

et al. 1987

Pediatr Res

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Radioimmuno- and radioreceptor-assayable insulin-like growth factor I (IGF-I) concentration was determined in plasma pools of rat fetuses on gestation day 21 following treatment of the pregnant rats with pharmacologic doses of betamethasone, dexamethasone, or cortisone on gestation days 12 and 13. Dose-related reduction of plasma concentration of IGF-I occurred after betamethasone or dexamethasone treatment. There was no change in IGF-I concentration after cortisone treatment. The changes in fetal IGF-I concentration after steroid treatment were parallel between the two assays. Comparison of the results with previous data showing the effects of identical treatment of pregnant rats on fetal body and organ growth suggests that the IGF-I changes correlate better with reduction of liver/body ratio than with reduction of body weight. The findings indicate that growth retardation after steroid treatment in the fetus is in part the result of factors other than IGF-I. This may include a direct effect of the glucocorticoids on skeletal tissue. Reduced IGF-I concentration may contribute to the growth deficit.

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“…In order to avoid possible confounders in assessing hormone levels at birth, we took blood samples from the neonates on the 2 nd day of life and did not use cord blood in which hormone levels may derive from the maternal circulation or from other maternal tissues, such as the placenta [22,23]. …”

Section: Methodsmentioning

confidence: 99%

Role of adiponectin and leptin on body development in infants during the first year of life

et al. 2010

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BackgroundThe control of growth and nutritional status in the foetus and neonate is a complex mechanism, in which also hormones produced by adipose tissue, such as adiponectin and leptin are involved. The aim of this study was to evaluate levels of adiponectin, leptin and insulin in appropriate (AGA) and small for gestational age (SGA) children during the 1st year of life and to correlate these with auxological parameters.MethodsIn 33 AGA and 29 SGA infants, weight, length, head circumference, glucose, insulin, adiponectin and leptin levels were evaluated at the second day of life, and at one, six and twelve months, during which a portion of SGA could show catch-up growth (rapid growth in infants born small for their gestational age).ResultsBoth total and isoform adiponectin levels were comparable between AGA and SGA infants at birth and until age one year. These levels significantly increased from birth to the first month of life and then decreased to lower values at 1 year of age in all subjects. Circulating leptin concentrations were higher in AGA (2.1 ± 4.1 ng/ml) than in SGA neonates (0.88 ± 1.03 ng/ml, p < 0.05) at birth, then similar at the 1st and the 6th month of age, but they increased in SGA from six months to one year, when they showed catch-up growth. Circulating insulin levels were not statistically different in AGA and SGA neonates at any study time point. Insulin levels in both AGA and SGA infants increased over the study period, and were significantly lower at birth compared to one, six and 12 months of age.ConclusionsDuring the first year of life, in both AGA and SGA infants a progressive decrease in adiponectin levels was observed, while a difference in leptin values was correlated with the nutritional status.

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Serum thymidine activity and insulin-like growth factors in the neonatal period

Cited by 4 publications

References 0 publications

Insulin-like growth factors (IGF) I and II in diabetic pregnancy: Suppression of normal pregnancy-induced rise of IGF-I

Insulin-like growth factors (IGF) I and II in diabetic pregnancy: Suppression of normal pregnancy-induced rise of IGF-I

The Effect of Glucocorticoids on Plasma Insulin-Like Growth Factor I Concentration in the Rat Fetus

Role of adiponectin and leptin on body development in infants during the first year of life

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