Serum-Thyreoglobulinbestimmung zur Verlaufskontrolle bei Schilddrüsenkarzinom-Patienten

Botsch, Hanno; Schulz, E.; Lochner, Bernd

doi:10.1055/s-0028-1129040

Cited by 19 publications

(4 citation statements)

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“…We could also confirm the general finding that plasma Tg is the most important parameter in the follow-up of these patients (Ashcraft & van Herle 1981;Black & Hoffenberg 1982;Botsch et al 1979;Charles et al 1980;Hüfner et al 1980;Jänsch et al 1981;Lo Gerfo et al 1979;Shlossberg et al 1979;Schlumberger et al 1981). The routine 131I follow-up scan with 2 mCi, however, seems of very limited value in detecting recurrences after a disease-free interval.…”

Section: Discussionsupporting

confidence: 87%

“…Numerous clinical studies have demonstrated the great sensitivity and reliability of this parameter in indicating métastases or a disease-free status (Botsch et al 1979;Charles et al 1980;Hüfner et al 1980;Jänsch et al 1981;Lo Gerfo et al 1977Shlossberg et al 1979;Schlumberger et al 1981). In recent years it has been recognized that the management of these patients is greatly improved by the use of plasma Tg measurements.…”

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confidence: 99%

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A comparison of the effectiveness of 131I whole body scans and plasma Tg determinations in the diagnosis of metastatic differentiated carcinoma of the thyroid: a retrospective study

Hüfner

Stumpf

Grußendorf

et al. 1983

Acta Endocrinologica

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In 68 patients with proved metastases of differentiated thyroid carcinoma the comparative value of the 131I whole body scan and plasma Tg measurements in establishing the diagnosis of metastasis or recurrence was analyzed retrospectively. At the time of primary therapy most metastases were diagnosed by the post \ x=req-\ therapy scan (78%). Eight of 9 scintigraphic negative metastases in the post-therapy scan were indicated by elevated Tg levels (> 10 ng/ml). Twenty-four of 28 recurrences after a disease free interval were negative in the 2 mCi 131I scan, 18 of these patients were Tg positive. Of the 4 recurrences with positive 131I uptake all were Tg positive; two of them only during endogenous TSH stimulation.

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Section: Discussionsupporting

confidence: 87%

mentioning

confidence: 99%

A comparison of the effectiveness of 131I whole body scans and plasma Tg determinations in the diagnosis of metastatic differentiated carcinoma of the thyroid: a retrospective study

Hüfner

Stumpf

Grußendorf

et al. 1983

Acta Endocrinologica

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“…However, as low Tg concentrations cannot exclude the respective disorder, a routine Tg determination seems not to be justified in benign thyroid diseases. (2,4,(7)(8)(9)14). Als weitere Indikationen zur Tg-Bestimmung werden die Fragen nach einer kindlichen Athyreose, einer Schilddrüsenektopie sowie angeborenen Hormonsynthesestörungen genannt (4,20).…”

Section: Discussionunclassified

Impact of the serum thyroglobulin concentration on the diagnostics of benign and malignant thyroid diseases

Rink¹,

Dembowski²,

Schroth³

et al. 2000

Nuklearmedizin

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Summary Aim of this study is to evaluate new and controversially discussed indications for determining the thyroglobulin (Tg) level in different thyroid diseases to support routine diagnostics. Methods: The following groups were included: 250 healthy subjects without goiter, 50 persons with diffuse goiter, 161 patients with multinodular goiter devoid of functional disorder (108 of them underwent surgery, in 17 cases carcinomas were detected), 60 hyperthyroid patients with autonomously functioning nodular goiter, 150 patients with Hashimoto’s thyroiditis and 30 hyperthyroid patients with Graves’ disease. Results: The upper limit of the normal range of the Tg level was calculated as 30 ng Tg/ml. The evaluation of the collective with diffuse goiter showed that the figure of the Tg level can be expected in a similar magnitude as the thyroid volume in milliliters. Nodular tissue led to far higher Tg values then presumed when considering the respective thyroid volume, with a rather high variance. A formula for a rough prediction of the Tg levels in nodular goiters is described. In ten out of 17 cases with thyroid carcinoma, the Tg was lower than estimated with thyroid and nodular volumes, but two patients showed a Tg exceeding 1000 ng/ml. The collective with functional autonomy had a significantly higher average Tg level than a matched euthyroid group being under suppressive levothyroxine substitution. However, due to the high variance of the Tg values, the autonomy could not consistently be predicted with the Tg level in individual cases. The patients with Hashimoto’s thyroiditis showed slightly decreased Tg levels. In Graves’ disease, a significantly higher average Tg level was observed compared with a matched group with diffuse goiter, but 47% of all Tg values were still in the normal range (< 30 ng/ml). Conclusion: Elevated Tg levels indicate a high probability of thyroid diseases, such as malignancy, autonomy or Graves’ disease. However, as low Tg concentrations cannot exclude the respective disorder, a routine Tg determination seems not to be justified in benign thyroid diseases.

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“…Some authors recommend its use for check-up studies, and perform whole-body scanning in cases with elevated TG levels only (2,10,16,31,60). Others (1,14,23,29,56) are more careful and consider both procedures to be complementary; some of them even suggest that the TG value does not influence their decision at all (18,19,22,33,42).…”

Section: Discussionmentioning

confidence: 99%

Serum Thyroglobulin Determinations in Patients with Differentiated Thyroid Carcinoma

Bednár¹,

Nĕmec²,

Zamrazil³

et al. 1983

Nuklearmedizin

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Serum thyroglobulin levels were measured in 636 patients with differentiated thyroid carcinoma, in whom altogether 1240 determinations were performed in different phases of disease and treatment. A modified sensitive radioimmunoassay was employed using an own high-specific thyroglobulin antibody. The results showed that both the majority of patients with functioning metastases accumulating radioiodine and with non-functioning metastases which could not be detected by scanning had higher serum TG levels, compared with a group of healthy subjects. However, “normal” TG values in patients with metastases, especially non-functioning, were found too. Thus, these findings decrease the diagnostic value of the TG determination. The highest TG values were found in patients with distant metastases of differentiated thyroid carcinoma (in lungs and bones); on the other hand, the proportion of patients with lymph-node(s) métastasés and “normal” TG levels was relatively high. We suggest that the serum TG determination cannot generally replace scanning with l31I and cannot serve as the only test, while being a helpful indicator in the long-term follow-up of differentiated thyroid cancer patients.

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Serum-Thyreoglobulinbestimmung zur Verlaufskontrolle bei Schilddrüsenkarzinom-Patienten

Cited by 19 publications

References 0 publications

A comparison of the effectiveness of 131I whole body scans and plasma Tg determinations in the diagnosis of metastatic differentiated carcinoma of the thyroid: a retrospective study

A comparison of the effectiveness of 131I whole body scans and plasma Tg determinations in the diagnosis of metastatic differentiated carcinoma of the thyroid: a retrospective study

Impact of the serum thyroglobulin concentration on the diagnostics of benign and malignant thyroid diseases

Serum Thyroglobulin Determinations in Patients with Differentiated Thyroid Carcinoma

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