Serum thyrotropin response to TRH administration in six healthy beagle dogs

Yagi, Katsuyoshi; Ohashi, Eiji; Tanabe, Shigeyuki; Uzuka, Yuji; Sarashina, Takao

doi:10.1136/vr.146.24.706

Veterinary Record

2000

DOI: 10.1136/vr.146.24.706

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Serum thyrotropin response to TRH administration in six healthy beagle dogs

Katsuyoshi Yagi

Eiji Ohashi

Shigeyuki Tanabe

et al.

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“…Advances in the ability to measure serum free thyroxine (fT 4 ) by dialysis [6,9] and serum canine thyroid-stimulating hormone (cTSH) [9] levels have contributed to this. By using these tests in combination with the thyrotropin-releasing hormone (TRH)-stimulating test [14] and the TSH-stimulating test [5], researchers can now examine in detail the influence of the hypothalamus-pituitary-thyroid axis on thyroid function. The above tests make it possible to examine previously undetectable minute physiological changes in thyroid function.…”

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confidence: 99%

Seasonal Changes in Serum Total Thyroxine, Free Thyroxine, and Canine Thyroid-Stimulating Hormone in Clinically Healthy Beagles in Hokkaido.

et al. 2001

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ABSTRACT. The purpose of this study was to evaluate seasonal influences on thyroid hormone levels of healthy outdoor dogs in Hokkaido. We surveyed serum basal total thyroxine (tT 4 ), free thyroxine (fT 4 ), and canine thyroid-stimulating hormone (cTSH) levels, and tT 4 levels after administration of TSH for a year. Basal tT 4 levels decreased in January, and increased in August and September. fT 4 levels increased in January and November. No significant seasonal variation was found in cTSH. tT 4 levels after administration of TSH in August and November increased. These results suggested that the thyroid gland may have been activated in November. We should take seasonal variation into consideration when thyroid function is tested. KEY WORDS: canine, season, thyroid hormone.J. Vet. Med. Sci. 63(11): 1241-1243, 2001 Recent progress in the development of hormone assays has made thyroid function testing for dogs more precise [1,8]. Advances in the ability to measure serum free thyroxine (fT 4 ) by dialysis [6,9] and serum canine thyroid-stimulating hormone (cTSH) [9] levels have contributed to this. By using these tests in combination with the thyrotropin-releasing hormone (TRH)-stimulating test [14] and the TSH-stimulating test [5], researchers can now examine in detail the influence of the hypothalamus-pituitary-thyroid axis on thyroid function. The above tests make it possible to examine previously undetectable minute physiological changes in thyroid function. Many studies have reported that thyroid function in humans adapts to environmental conditions such as ambient temperature, photoperiod, and season, but the results have not been consistent because more than one parameter may mediate thyroid function [2-4, 10]. Although similar findings were reported in rat [11,13], sheep [15], and dog [12], the only hormones measured were serum total thyroxine (tT 4 ), triiodothyronine (tT 3 ), and TSH. There has been only one report about seasonal changes in thyroid function in the dog [12], but the details of such changes have remained unclear because only tT 4 and tT 3 levels were measured.The purpose of the present study was to evaluate the influence of the season on the thyroid hormone levels of healthy outdoor dogs. We surveyed basal tT 4 , fT 4 , cTSH levels, and tT 4 levels after administration of TSH for a year. Subject dogs -Ten clinically healthy beagles were used, ranging in age from 2 to 7 years and weighing 8.0 to 15.0 kg. There were 7 males and 3 females. The dogs were separated into two groups by sex, and had been raised outdoors since puppyhood, fed a standard commercial dry dog food once daily at 4 p.m., and given water freely at the Laboratory of Veterinary Internal Medicine, Obihiro University of Agriculture and Veterinary Medicine. Exposure to sunlight was good even though the outdoor runs had roofs. Wind did not blow strongly because of surrounding buildings. The history and results of routine physical examinations and routine laboratory tests (CBC, total cholesterol, ALT, ALP, BUN, and creatinine) wer...

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Seasonal Changes in Serum Total Thyroxine, Free Thyroxine, and Canine Thyroid-Stimulating Hormone in Clinically Healthy Beagles in Hokkaido.

et al. 2001

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Geriatrik Hasta Köpeklerde Fiziksel, Biyokimyasal ve Radyolojik Bulguların Değerlendirilmesi

Haydardedeoğlu

Kalinbacak

2015

Atatürk Üniversitesi Vet. Bil. Derg.

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Öz: Bu araştırma Ankara Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalı Kliniği'ne getirilen geriatrik yaş aralığında farklı ırk, yaş ve kiloda 52'si erkek, 48'i dişi toplam 100 sahipli hasta köpek üzerinde yürütüldü. Köpekler vücut ağırlıklarına göre 4 gruba ayrılmış olup 10 kg'dan küçük köpekler grup 1 (n:59); 10-24.9 kg arası köpekler grup 2 (n:20); 25-45 kg arasındaki köpekler grup 3 (n:17); 45 kg'dan büyük köpekler grup 4 (n:4) olarak araştırmaya alındı. Çalışmaya dahil olan 100 köpekte, tüm değerlendirmeler sonucunda 47 farklı hastalık ortaya konuldu. Köpeklerin birçoğunda birden fazla hastalığın birlikte seyrettiği belirlendi. Saptanan hastalıkların organ sistemlerine göre sınıflandırılması yapıldığında, 54 köpekte dolaşım sistemi, 21 köpekte sindirim sitemi, 19 köpekte üriner sistem, 20 köpekte genital sistem, 16 köpekte solunum sistemi, 15 köpekte endokrin ve metabolik hastalıklar, 9 köpekte lenforetüküler (dalak ve lenf yumruları) sistem, 7 köpekte lokomotor sistem ve sinir sitemi hastalığı, 4 köpekte kulak ve işitme hastalıkları, 2 köpekte ise dermatolojik bozukluklar tespit edildi. Hastalıkların görülme yüzdeleri dikkate alındığında en sık rastlanılan 10 hastalık, kronik valvuler kalp hastalığı %22.81, kardiyomegali %6.43, akciğerlerde kitlesel oluşum %5.85, pyometra %4.09, memede kitlesel oluşum %4.09, kronik böbrek yetmezliği %4.09, sistitis %2.92, kolestitis %2.92, perikardiyalefüzyon %2.34 ve diabetesmellitus %2.34 olarak belirlendi.

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Effects of withholding feed on thyrotropin-releasing hormone stimulation test results and effects of combined testing on oral sugar test and thyrotropin-releasing hormone stimulation test results in horses

Restifo¹,

Frank²,

Hermida³

et al. 2016

ajvr

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OBJECTIVE To assess effects of withholding feed on thyrotropin-releasing hormone (TRH) stimulation test results used in diagnosis of pituitary pars intermedia dysfunction in horses and determine effects of combined testing on results of the TRH stimulation test and the oral sugar test (OST) used in diagnosis of equine metabolic syndrome. ANIMALS 30 adult horses. PROCEDURES All horses underwent TRH stimulation tests under fed and nonfed conditions, an OST alone, and an OST combined with TRH stimulation testing. For TRH stimulation tests, plasma ACTH concentrations were measured before (baseline) and 10 minutes after (poststimulation) IV TRH administration. For the OST, plasma glucose and insulin concentrations were measured before (baseline) and 60 and 90 minutes after oral corn syrup administration. For combined testing, the TRH stimulation test was initiated immediately after 60-minute posttreatment sample collection for the OST. Results were compared among methods by Wilcoxon matched-pairs, signed rank tests, paired t tests, and Bland-Altman analysis. RESULTS Feeding conditions did not affect median ACTH concentrations when TRH stimulation tests were performed alone. Median baseline ACTH concentration did not differ between TRH stimulation tests performed alone (under fed or nonfed conditions) and those combined with OSTs. Median poststimulation ACTH concentration was significantly lower for combined tests than for solitary TRH stimulation tests. Mean 60-minute plasma glucose concentration was significantly lower for solitary OSTs than for combined tests, but this difference could not be attributed to TRH administration. CONCLUSIONS AND CLINICAL RELEVANCE Combined testing in the manner described impacted ACTH concentrations during TRH stimulation tests and is not recommended at this time.

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Serum thyrotropin response to TRH administration in six healthy beagle dogs

Cited by 3 publications

References 1 publication

Seasonal Changes in Serum Total Thyroxine, Free Thyroxine, and Canine Thyroid-Stimulating Hormone in Clinically Healthy Beagles in Hokkaido.

Seasonal Changes in Serum Total Thyroxine, Free Thyroxine, and Canine Thyroid-Stimulating Hormone in Clinically Healthy Beagles in Hokkaido.

Geriatrik Hasta Köpeklerde Fiziksel, Biyokimyasal ve Radyolojik Bulguların Değerlendirilmesi

Effects of withholding feed on thyrotropin-releasing hormone stimulation test results and effects of combined testing on oral sugar test and thyrotropin-releasing hormone stimulation test results in horses

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