THIS STUDY aimed to determine the changes in the hormonal and biochemical profile of pregnant dromedary camels to provide a baseline data under Egyptian climatic conditions. Blood samples were collected from15 pregnant she-camels aged 8-11 years old just postconception and thereafter monthly during gestation period and during periparturient period (at days 15, 7,4and 1prepartum,at parturition and at days 1, 4, 7 and 15 postpartum).Progesterone level increased significantly (P<0.05) after conception and during the1 st and the 2 nd trimester of pregnancy then declined significantly (P<0.05) during the 3 rd trimester. Meanwhile its level decreased significantly (P<0.05) during periparturient period. Cortisol level significantly (P<0.05) increased at the 3 rd trimester and continued increasing significantly during prepartum period with a maximum level on the day of parturition after that it was markedly decreased during the few days postpartum to day 15 postpartum. Thyroid hormones levels were significant (P<0.05) decreased in their levels from early to late gestation then increased significantly (P<0.05) from day of parturition to day 15 postpartum. Total protein and albumin were significantly low (P<0.05) in the 2 nd and the 3 rd trimesters than the first one with no significance alterations in globulin levels. Total antioxidant, glutathione and ascorbic acid levels were lower in the 3 rd trimester than others, whereas the levels were relatively low in prepartum than 15 days postpartum. Malondialdehyde concentration was significantly increased (P<0.05) during late pregnancy period as a result of the physiological stress of pregnancy