Serum Trace Elements in Elderly Frail Patients with Oropharyngeal Dysphagia

Leibovitz, Arthur; Lubart, Emily; Wainstein, Julio; Dror, Yosef; Segal, Refael

doi:10.3177/jnsv.55.407

Cited by 8 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Utmost care was taken to avoid potential pre-analytical contamination during specimen acquisition and treatment. A conventional wet acid digestion method was used to digest serum as previously described [13]. Briefly, 0.4 ml of serum sample and 3 ml of nitric acid (65%) were added into a 25 ml beaker, and digested at 70˚C -80˚C on an electric hot plate for 90 min.…”

Section: Methodsmentioning

confidence: 99%

Relationship between Serum Levels of Some Trace Elements, Disease Duration and Severity in Patients with Knee Osteoarthritis

Mahmood¹

2015

View full text Add to dashboard Cite

Background: Many trace elements in the biological system, including boron, are involved in various vital processes related to health and diseases. Boron has been proved to have a role in decreasing inflammatory pain, joint stiffness and other disabling symptoms associated with osteoarthritis (OA). Aims and Objective: The purpose of the present study was to evaluate the relationship between serum concentrations of copper (Cu), zinc (Zn), selenium (Se), manganese (Mn) and magnesium (Mg) with disease duration and severity in patients with knee OA. Methods: A total of 43 patients with knee OA were clinically evaluated and serum concentrations of Cu, Zn, Se, Mn and Mg were measured, and the results were compared with those of healthy controls. Trace elements levels were correlated with disease duration and severity. Results: Serum Cu and the value of Cu/Zn were significantly elevated in OA patients and positively correlated with disease duration and severity. Serum Zn, Se and Mn were significantly lower in patients compared with controls; Zn and Se were found to be negatively and significantly correlated with disease duration and severity. Conclusion: Patients with knee OA had higher levels of Cu and larger value of Cu/Zn and lower levels of serum Zn and Se; these changes were potentially correlated with the duration and severity of disease.

show abstract

Section: Methodsmentioning

confidence: 99%

Relationship between Serum Levels of Some Trace Elements, Disease Duration and Severity in Patients with Knee Osteoarthritis

Mahmood¹

2015

View full text Add to dashboard Cite

show abstract

“…Toward these efforts, various studies have utilized a wide range of human specimens including, human serum, blood, tissues, urine, and saliva as biomarkers for effective biomonitoring of trace element concentrations [31][32][33][34][35]. However, these biomarkers have some major drawbacks including, sample susceptibility to contamination, sample decomposition, and instability.…”

Section: Introductionmentioning

confidence: 99%

Use of Flame Atomic Absorption Spectroscopy and Multivariate Analysis for the Determination of Trace Elements in Human Scalp

Fakayode¹,

Owen²,

Pollard³

et al. 2013

AJAC

View full text Add to dashboard Cite

The analysis of trace elements in human hair for use as biomarkers continues to generate considerable interest in environmental and bioanalytical studies, medical diagnostics, and forensic science. This study investigated the concentrations of essential and toxic elements (Fe, Mg, Ca, Cu, Zn, Cr, Cd, and Pb) using flame atomic absorption spectroscopy (FAAS) in human scalp hair obtained from subjects living in Forsyth County, North Carolina, USA. The influence of age, sex, race, and smoking habits on the levels of trace elements in the hair samples were also investigated. Additionally, analyses were subjected to a statistical, regression, and principal component analysis to evaluate inter-elemental association and possible pattern recognition in hair samples. Furthermore, Ca/Mg and Zn/Cu ratios, which are often used to evaluate the degree of Ca and Cu utilization in humans and as markers for various health related issues including, atherosclerosis, hypertension, insulin sensitivity, and pancreatic cancer, were calculated. The overall mean concentrations of Fe (25 µg/g), Ca (710 µg/g), Mg (120 µg/g), Zn (190 µg/g), Cu (12 µg/g), and Cr (0.20 µg/g) were found in hair samples. The trace element concentrations varied widely in hair samples as demonstrated by large range of concentrations obtained for each element. However, levels of Cd and Pb elements of <0.030 µg/g were detected in hair sample. In general, the levels of the trace elements in hair samples were poorly correlated. However, significant correlations were found between Ca and Mg (r = 0.840, p = 0.05). The levels of Fe, Ca, Mg, Zn, Cu, and Cr in hair samples and the calculated Ca/Mg and Zn/Cu ratios were found to be largely correlated with age, race, sex, and smoking habits.

show abstract

“…The consequences of these two conditions may be related to worsening of the cardiovascular and the cognitive status and the deterioration of immunocompetence ( 13 , 14 ). The status of the trace elements, as we have recently shown, also seems to affect the vulnerability of this population ( 15 ).…”

Section: To the Editormentioning

confidence: 99%

Serum Trace Elements in Elderly Frail Patients with Oropharyngeal Dysphagia

Cited by 8 publications

References 25 publications

Relationship between Serum Levels of Some Trace Elements, Disease Duration and Severity in Patients with Knee Osteoarthritis

Relationship between Serum Levels of Some Trace Elements, Disease Duration and Severity in Patients with Knee Osteoarthritis

Use of Flame Atomic Absorption Spectroscopy and Multivariate Analysis for the Determination of Trace Elements in Human Scalp

Tube-Enteral Feeding for Frail Elderly Patients with Oropharyngeal Dysphagia—Not Only Yes or No, but When?

Contact Info

Product

Resources

About