Serum transaminase elevation in children with rotavirus gastroenteritis: Seven years’ experience

Akelma, Ahmet Zülfikar; Kütükoğlu, Irem; Köksal, Tülin; Cizmeci, Mehmet Nevzat; Kanburoğlu, Mehmet Kenan; Çatal, Ferhat; Mete, Emin; Bozkaya, Davut; Namuslu, Mehmet

doi:10.3109/00365548.2012.740573

Cited by 24 publications

(23 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, abnormal enzyme levels have been observed in children with rotavirus disease, which might be related to rotavirus-associated vomiting, dehydration or nonintestinal pathology. For example, mildly increased levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood can sometimes be observed during rotavirus infection and might be due to rotavirus-induced mild hepatitis 112,113 .…”

Section: Diagnosis Screening and Preventionmentioning

confidence: 99%

Rotavirus infection

Crawford

Ramani

Tate

et al. 2017

Nat Rev Dis Primers

554

558

View full text Add to dashboard Cite

Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in >200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system. In addition, rotavirus infections can lead to antigenaemia (which is associated with more severe manifestations of acute gastroenteritis) and viraemia, and rotavirus can replicate in systemic sites, although this is limited. Reinfections with rotavirus are common throughout life, although the disease severity is reduced with repeat infections. The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific immunoglobulin A has a role in both aspects. The management of rotavirus infection focuses on the prevention and treatment of dehydration, although the use of antiviral and anti-emetic drugs can be indicated in some cases.

show abstract

Section: Diagnosis Screening and Preventionmentioning

confidence: 99%

Rotavirus infection

Crawford

Ramani

Tate

et al. 2017

Nat Rev Dis Primers

554

558

View full text Add to dashboard Cite

show abstract

“…The results showed that age, feeding pattern, and CNS damage were significant independent risk factors for the prognosis of infantile RV enteritis. Although RV enteritis is often complicated by hepatic functional damage (Rauschenfels et al, 2009;Kawashima et al, 2012;Akelma et al, 2013), multivariate logistic analysis revealed no correlation between hepatic functional damage and the prognosis of RV enteritis. This may be because myocardial and hepatic damages are temporary rather than irreversible in most infants with RV enteritis.…”

Section: Discussionmentioning

confidence: 93%

Analysis of prognostic factors for infantile rotavirus infection

Zhou

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. In this study, we investigated the prognostic factors of infantile rotavirus (RV) infection. A total of 102 infants with RV enteritis were divided into 2 groups according to the standards of improvement and cure at the time of discharge from the hospital: improvement group (N = 58; 47 males and 11 females with an average age of 15.19 ± 5.03 months) and the cure group (N = 44; 34 males and 10 females with an average age of 10.02 ± 4.92 months). Both groups were phlebotomized for the detection of serum glutamic oxaloacetic aminotransferase, creatine kinase-MB, and lactate dehydrogenase. Prognostic factors and clinical data were analyzed by univariate and multivariate logistic analysis. Among the 102 cases of RV infection, 58 were cured and 44 were improved. Univariate analysis showed that the 2 groups were significantly different in age, feeding pattern, concentrations of serum glutamic oxaloacetic aminotransferase, creatine kinase-MB, and lactate dehydrogenase, and central nervous system damage. Logistic regression analysis showed that age, feeding, and central nervous system damage were significant independent prognostic factors for RV enteritis (P < 0.05). There were no statistical differences in gender, 791©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (1): 790-796 (2015) Factors for infantile rotavirus infection course of disease, and respiratory infection (P < 0.05). Both myocardial and hepatic damages presented a temporary feature in the infants and had no significant influence on prognosis. Age, feeding pattern, and central nervous system damage are significant independent prognostic factors for RV infection. These factors should be carefully considered in clinical practice.

show abstract

“…All currently available data suggest that viremia is a part of the natural course of rotavirus infection, that rotavirus is not confined to the intestinal tract, and that it routinely disseminates systemically beyond the intestine ( 6 ). Such systemic manifestations as elevated hepatic transaminase, in addition to the features of rotavirus gastroenteritis, have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Systemic Manifestation of Rotavirus Infection in Children: A Report of Three Cases

Akçaboy

Oğuz

Açoğlu

et al. 2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

IntroductionRotavirus is a leading cause of acute gastroenteritis in children. Although the clinical complaints associated with rotavirus are generally gastrointestinal, including vomiting and diarrhea, data suggest that it can also cause symptoms that extend beyond the gastrointestinal tract.Case PresentationsWe report three pediatric cases of rotavirus infection: one accompanied by encephalopathy and two with elevated hepatic transaminase activity. The patients were admitted to Dr. Sami Ulus maternity and children’s health and diseases training and research hospital, Ankara, Turkey, from 2012 - 2014. The presented patients’ aspartate aminotransferase (AST) (1765-2614 IU L-1) and alanine aminotransferase (ALT) (1448-3558 IU L-1) levels are, to date, the highest reported levels associated with rotavirus infections, and suggest that the rotavirus can cause severe hepatic transaminase elevation.ConclusionsThis report aimed to increase awareness of the occurrence of extra-intestinal systemic manifestations of rotavirus infection. Although such cases may be rare, they still suggest that that rotavirus is a systemic viral infection.

show abstract

Serum transaminase elevation in children with rotavirus gastroenteritis: Seven years’ experience

Abstract: In this study, our results clearly signify a liver influence in rotavirus infections. Therefore, rotavirus infections should be kept in mind when evaluating the aetiology of transaminase elevation in patients with acute gastroenteritis.

Cited by 24 publications

References 21 publications

Rotavirus infection

Rotavirus infection

Analysis of prognostic factors for infantile rotavirus infection

Systemic Manifestation of Rotavirus Infection in Children: A Report of Three Cases

Contact Info

Product

Resources

About