Serum transaminase elevation in Patients with rotavirus gastroenteritis

Erdoğan, Seher; Yazar, Ahmet Sami; Güven, Şirin; Durak, Umut; Akova, Sevgi

doi:10.4328/jcam.5225

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…In the study of Erdogan et al, while ALT and AST values were higher in patients with positive Rotavirus test, no significant difference was found in terms of WBC, PLT, PCT, MPV and CRP values [30]. The results of our study were similar to those in the literature.…”

Section: Discussionsupporting

confidence: 89%

Konya yöresindeki akut gastroenteritli çocukların değerlendirilmesi

Kılıç

Atwan

Yazar

et al. 2021

Family Practice and Palliative Care

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Introduction: Acute gastroenteritis is a major cause of pediatric morbidity and mortality around the world. It remains a frequent reason for infection-related admissions to emergency units among all age groups. Epidemiologic knowledge about etiology of gastroenteritis in a certain area allows early and correct diagnosis. The current study aimed at evaluating the prevalence of bacterial, viral, and parasitic pathogens in children with gastroenteritis who admitted to pediatric emergency unit. Methods: The demographic, clinical and laboratory data of 450 children with acute gastroenteritis, within the age range of 0 months to 18 years who admitted to Pediatric Emergency Department of Meram Faculty of Medicine from September 2018 to September 2019 were retrospectively analyzed. Results: While 31.10% of the patients had etiological agents, 68.90% of the patients could not be identified. The identified pathogens were 2.10% bacteria, 82.20% virus, 15.70% parasite. The most common pathogen was Rotavirus with a rate of 72.90%. This was followed by E. histolytica with 15.00% and Adenovirus with 9.30%. Rotavirus was most frequently detected at the age of 2 years, and E. histolytica was most frequently detected at the age of 5 years. Rotavirus was most common in the winter season [33.7%]. 7.10% of the patients were hospitalized. The average length of hospital stay was 3.34 ± 2.19 days. Conclusion:Rotavirus, E. histolytica and Adenovirus were the most prevalent agents of diarrhea in children aged 0 month to 18 years who admitted to emergency unit in this study.

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Section: Discussionsupporting

confidence: 89%

Konya yöresindeki akut gastroenteritli çocukların değerlendirilmesi

Kılıç

Atwan

Yazar

et al. 2021

Family Practice and Palliative Care

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“…The prevalence was highly reported during the dry season [ 15 , 21 ], bottle-fed children [ 15 , 22 , 23 ], and children with group A blood type [ 15 , 24 , 25 ]. Moreover, laboratory investigations revealed a significantly high level of serum transaminase among children infected with rotavirus [ 26 , 27 , 28 ]. Among many studies conducted worldwide, it was found that rotavirus infected children have a high chance of developing dehydration as a complication, and thus, must be closely monitored [ 7 , 16 , 29 , 30 ].…”

Section: Causative Agents Of Agementioning

confidence: 99%

“…Amongst EIA kit used were Premier Rotaclone, Meridian Bioscience Inc., Cincinnati, OH, USA [ 10 , 11 , 12 , 19 , 93 , 94 ], RIDASCREEN Rotavirus R Biopharm AG, Darmstadt, Germany [ 15 , 93 ], and ProSpect Rotavirus Test, Oxoid Ltd., UK [ 22 , 93 ]. Rotavirus antigens can also be detected by using enzyme-linked immunosorbent assay (ELISA) [ 12 , 16 , 18 , 20 , 28 , 30 ] which includes ELISA kits such as Premier Rotaclone, Meridian Bioscience, Inc. [ 12 ], Fecal Rotavirus Antigen ELISA Kit (EDI, CA, USA) [ 16 ], ProSpecTM Rotavirus Microplate Assay, Oxoid [ 20 ] and Rota Antigen Test Device, Cambridge [ 28 ]. ELISA can also be used in the detection of rotavirus-specific IgM [ 29 ].…”

Section: Biomarkers In the Detection Of Common Aetiological Agents Of Agementioning

confidence: 99%

Acute Infectious Gastroenteritis: The Causative Agents, Omics-Based Detection of Antigens and Novel Biomarkers

et al. 2021

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Acute infectious gastroenteritis (AGE) is among the leading causes of mortality in children less than 5 years of age worldwide. There are many causative agents that lead to this infection, with rotavirus being the commonest pathogen in the past decade. However, this trend is now being progressively replaced by another agent, which is the norovirus. Apart from the viruses, bacteria such as Salmonella and Escherichia coli and parasites such as Entamoeba histolytica also contribute to AGE. These agents can be recognised by their respective biological markers, which are mainly the specific antigens or genes to determine the causative pathogen. In conjunction to that, omics technologies are currently providing crucial insights into the diagnosis of acute infectious gastroenteritis at the molecular level. Recent advancement in omics technologies could be an important tool to further elucidate the potential causative agents for AGE. This review will explore the current available biomarkers and antigens available for the diagnosis and management of the different causative agents of AGE. Despite the high-priced multi-omics approaches, the idea for utilization of these technologies is to allow more robust discovery of novel antigens and biomarkers related to management AGE, which eventually can be developed using easier and cheaper detection methods for future clinical setting. Thus, prediction of prognosis, virulence and drug susceptibility for active infections can be obtained. Case management, risk prediction for hospital-acquired infections, outbreak detection, and antimicrobial accountability are aimed for further improvement by integrating these capabilities into a new clinical workflow.

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Akut Gastroenteritli Çocuklarda Etkenlere Göre Klinik ve Laboratuvar Bulgularının Karşılaştırılması

Özmen

Acıpayam

Güneş

et al. 2020

STED / Sürekli Tıp Eğitimi Dergisi

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Objective: Acute gastroenteritis (AGE) is a common infection of childhood. Our study aims to evaluate the clinical and laboratory parameters of children hospitalized with acute gastroenteritis. Material and method: One hundred thirty pediatric (aged 0-17 years) patients hospitalized at our clinic between January 2016 and January 2019 with a diagnosis of AGE, who experienced diarrhea for 14 days or shorter were included in our study. They were separated into two groups according to the agents: The patients with viral AGE and those with parasitic AGE. Patients' demographics, laboratory and clinical data were obtained from patients' files and statistical analyses were performed. Findings: Of the 130 patients included in the study, 47 were in the parasitic and 83 were in the viral AGE group. While there was no gender difference between the groups, the mean age was lower in the viral AGE group (p<0,001). The duration of diarrhea was longer and vomiting was more common in the viral AGE group (p=0,031, p=0,02, respectively). Parasitic AGE was seen mostly in summer and viral AGE was seen mostly during winter (p=0,01). The duration of diarrhea was found to be positively correlated with the length of hospital stay (p<0,001, r=0,656), but this duration was negatively correlated with mean platelet volume, neutrophil count and C-reactive protein (p=0,01, r=-0,21, p=0,02, r=-0,193, p=0,01, r=-0,209, respectively). Conclusions: We found that the length of stay, the duration of diarrhea were longer and the prevalence of vomiting was higher in viral gastroenteritis. Besides, we concluded that the number of viral cases was larger in winter while the incidence of parasitic cases was higher in summer and acute-phase markers were higher in the cases with the parasitic origin.

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Serum transaminase elevation in Patients with rotavirus gastroenteritis

Cited by 3 publications

References 12 publications

Konya yöresindeki akut gastroenteritli çocukların değerlendirilmesi

Konya yöresindeki akut gastroenteritli çocukların değerlendirilmesi

Acute Infectious Gastroenteritis: The Causative Agents, Omics-Based Detection of Antigens and Novel Biomarkers

Akut Gastroenteritli Çocuklarda Etkenlere Göre Klinik ve Laboratuvar Bulgularının Karşılaştırılması

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