Serum TSH is positively associated with BMI

Nyrnes, Audhild; Jorde, Rolf; Sundsfjord, Johan

doi:10.1038/sj.ijo.0803112

Cited by 250 publications

(238 citation statements)

References 32 publications

(27 reference statements)

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“…In a large population study conducted in euthyroid patients from Denmark, 3 the body mass index (BMI) was found to be positively associated with serum TSH and inversely related to free tetraiodotyronine (FT 4 ). This finding has been confirmed in other studies, [4][5][6] but not in all. 7 However, in the latter report, study participants were referrals to a thyroid clinic.…”

Section: Introductionsupporting

confidence: 82%

Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss

et al. 2009

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Objective: Increased thyroid-stimulating hormone (TSH) and FT 3 levels are often found in clinically euthyroid obese individuals. Information on thyroid gene expression in human adipose tissue is scarce. The objective of this study was to measure the expression of the TSH receptor (TSHR) and the thyroid hormone receptor (TRa1) genes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese individuals and to test the effect of weight loss on these genes. Study Design and Participants: This study is a prospective study involving 107 obese (body mass index (BMI) ¼ 46±8 kg m À2 , 52 with type 2 diabetes or impaired glucose tolerance) and 12 lean nondiabetic participants. A total of 27 obese patients were restudied 1 year after gastric bypass surgery. Total RNA was extracted from SAT and VAT obtained at baseline from all participants, and from SAT in obese patients post surgery. Results: Circulating TSH and FT 3 levels were 170 and 36%, respectively, higher in obese patients than in controls. In SAT, TSHR and TRa1 were reduced in the obese by 67 and 33%, respectively, regardless of glucose tolerance. A similar trend was found in VAT. Post surgery, a BMI decrease of 33% was associated with a decrease in TSH and FT 3 levels and with a 150 and 70% increase in SAT of TSHR and TRa1, respectively. Conclusion: In both subcutaneous and visceral fat, the thyroid gene expression (especially TSHR) is reduced in obesity. The reversal of these changes with major weight loss and the reciprocal changes in plasma TSH and FT 3 levels suggest a role for adipocytes in the regulation of TSH and thyroid hormones.

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Section: Introductionsupporting

confidence: 82%

Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss

et al. 2009

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“…There are several lines of evidence that suggest serum cystatin C may have extra-renal sources, particularly in pathways that may associate with body weight. Serum cystatin C has been shown to be associated with thyroid function, corticosteroid administration, and C reactive protein, conditions that are associated with alterations in body weight [24][25][26] . Thus, there may be additional potential mechanisms for the association between BMI and serum cystatin C, observed in the current study, above and beyond kidney function.…”

Section: Discussionmentioning

confidence: 99%

Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United States

Muntner

Winston²,

Uribarri³

et al. 2008

The American Journal of Medicine

129

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“…The potential impact of minor changes in thyroid function on body weight and other anthropometric measures, especially in euthyroid subjects (4)(5)(6), has been investigated. Thus, the definition of the upper limit of normal serum TSH range has been under intense debate in the literature (7,8).…”

Section: Introductionmentioning

confidence: 99%

Association between serum TSH concentration within the normal range and adiposity

Souza

Sichieri²

2011

European Journal of Endocrinology

102

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Background: Overt hypothyroidism is clearly related to body weight gain and greater adiposity, but the range of hormonal change in serum TSH concentration associated with weight gain remains a focus of debate. Aim: The aim of this review was to assess studies that evaluated the relationship between anthropometric measures and serum TSH concentration in euthyroid subjects. Methods: Studies held on the Ovid MEDLINE database were searched and original articles published from 2000 to 2010 were included. The literature search was restricted to studies conducted in humans aged 18 years or older and written in English, Spanish, or Portuguese. Studies that evaluated the association between anthropometric measures and serum TSH within the normal range as the primary objective, as well as additional analysis, were included. Results: A total of 29 studies met the inclusion criteria. Of the 29 studies, 18 showed a positive relationship between measures of adiposity and serum TSH. Despite the plausibility of this association, only two studies reported longitudinal findings. The influence of smoking on the association between serum TSH and anthropometric measures was evaluated in only three studies and remains unclear. Conclusion: Thus, further longitudinal studies are needed to better understand the mechanisms by which TSH concentration might impact body weight.

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Serum TSH is positively associated with BMI

Cited by 250 publications

References 32 publications

Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss

Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss

Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United States

Association between serum TSH concentration within the normal range and adiposity

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