Serum tumour necrosis factor‐α levels in cancer patients are discontinuous and correlate with weight loss

Bossola, Maurizio; Muscaritoli, Maurizio; Bellantone, Rocco Domenico Alfonso; Pacelli, Fabio; Cascino, A.; Sgadari, Antonio; Battaglia, Federica; Piccioni, Elisabetta; Scambia, Giovanni; Doglietto, GB; Fanelli, Filippo Rossi

doi:10.1046/j.1365-2362.2000.00751.x

Cited by 33 publications

(25 citation statements)

References 35 publications

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“…The positive correlation between weight loss and serum TNF alpha levels was also observed in other studies. Bossola et al [20] showed that Table 3. Severity data and evolution aspects of patients with tuberculosis and levels of TNF-alpha.…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis

Júnior¹,

Santos²,

Castro³

et al. 2008

Braz J Infect Dis

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This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 ± 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 ± 1495.29 pg/mL) (p<0.05). Patients that lost weight had higher TNF alpha levels (15468.54 ± 4580.54 pg/ mL) than those that didn't loose weight (2904.98 ± 1367.89) (p<0.05). The levels of TNF alpha were higher in patients with a positive PPD skin test than in those with a negative PPD test (p<0.05). There was a positive correlation between patients' clinical severity and the serum levels of TNF alpha. In patients with successive measurements of TNF alpha, we observed that there was a drop in cytokine levels, and also a clinical improvement concomitantly. We concluded that there was a correlation between serum TNF alpha levels and chest X-Ray alterations, loss of weight, positive PPD skin test and clinical severity in patients with tuberculosis. There was evidence of a worse clinical outcome in patients with tuberculosis that presented higher TNF alpha serum levels.

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Section: Discussionmentioning

confidence: 99%

Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis

Júnior¹,

Santos²,

Castro³

et al. 2008

Braz J Infect Dis

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“…Recent evaluations have linked protein catabolism to high levels of cytokines, particularly TNF-a [14,15]. It is the major mediator of cachexia observed in tumor patients (hence the other name cachectin) [16].…”

Section: Discussionmentioning

confidence: 99%

TNF-α levels in children with growth hormone deficiency and the effect of long-term growth hormone replacement therapy

Andıran

Yordam

2007

Growth Hormone & IGF Research

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“…10,11 Increased TNF␣ levels were also associated with weight loss in patients with pancreatic carcinoma 12 and gastrointestinal carcinoma. 13 Nakashima et al 14 reported that TNF␣ contributed to the complex syndrome of cachexia in patients with CaP: TNF␣ was detected in 75% of patients with recurrent disease, and the body mass indices of patients with elevated serum TNF␣ levels were significantly lower compared with the corresponding values in patients with undetectable serum TNF␣ levels. However, some clinical studies failed to correlate TNF␣ levels with the cachectic state.…”

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Elevation of cytokine levels in cachectic patients with prostate carcinoma

Pfitzenmaier

Vessella

Higano

et al. 2003

Cancer

144

100

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BACKGROUNDApproximately 60–70% of patients with advanced prostate carcinoma (CaP) suffer from cachexia, one of the most devastating conditions associated with advanced malignant disease. The pathophysiology of cachexia is multifactorial, and several cytokines, such as tumor necrosis factor α (TNFα) and interleukin 1 (IL‐1), IL‐6, and IL‐8, may be involved. The objective of the current study was to determine whether cachexia associated with advanced CaP is accompanied by increased serum levels of TNFα, IL‐1β, IL‐6, and IL‐8.METHODSThe levels of TNFα, IL‐1β, IL‐6, IL‐8, and prostate specific antigen (PSA) were examined in serum samples from normal donors (n = 10 donors), from patients with organ‐confined CaP (n = 19 patients), from patients with advanced CaP without cachexia (n = 17 patients), and from patients with cachectic CaP (n = 26 patients). DPC Immulite and Abbott IMx Total‐PSA assays were used to determine cytokine and PSA levels, respectively.RESULTSLevels of TNFα, IL‐6, and IL‐8 were elevated significantly in the group of patients with advanced, cachectic CaP compared with patients who were without cachexia. In the cachectic patients, levels of TNFα were correlated positively with IL‐8, and there was no correlation between PSA levels and any of the cytokine levels. IL‐1β levels were below the limit of detection in all samples.CONCLUSIONSThe current results show that levels of TNFα, IL‐6, and IL‐8 were increased in CaP patients with cachexia. Increased levels of these cytokines were not correlated with PSA levels, suggesting that they are regulated by a mechanism that is independent of PSA synthesis. Additional fundamental research is needed to determine the mechanisms involved and to identify potential therapeutic targets in patients with cachexia. Cancer 2003;97:1211–6. © 2003 American Cancer Society.DOI 10.1002/cncr.11178

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Serum tumour necrosis factor‐α levels in cancer patients are discontinuous and correlate with weight loss

Abstract: The present study demonstrates that TNF is intermittently or discontinuously detectable in patients with gastrointestinal cancer and that its levels correlate with the severity of weight loss.

Cited by 33 publications

References 35 publications

Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis

Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis

TNF-α levels in children with growth hormone deficiency and the effect of long-term growth hormone replacement therapy

Elevation of cytokine levels in cachectic patients with prostate carcinoma

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