Serum Urate Concentrations Among University Professors

Brooks, George W.

doi:10.1001/jama.1966.03100060055017

Cited by 84 publications

(36 citation statements)

References 11 publications

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“…The subjects were divided into three groups: (1) those who completed college (CC), (2) those who attempted college but dropped out (AC), and (3) those who did not attend college (NC). Evaluation of mean high-school grades among the three groups suggested that the AC group was more highly motivated to obtain further education, in spite of poor grades.…”

mentioning

confidence: 99%

Serum Urate Concentrations in Male High-School Students

Kasl¹

1966

JAMA

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The results of this study offer additional evidence of the relationship of serum uric acid (SUA) levels to achievement-oriented behavior. The SUA determinations were made on 62 male high-school junior-and senior\p=m-\ level students and were repeated 4 1/2 years later. The correlation between the two determinations was 0.76.The subjects were divided into three groups: (1) those who completed college (CC), (2) those who attempted college but dropped out (AC), and (3) those who did not attend college (NC)

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confidence: 99%

Serum Urate Concentrations in Male High-School Students

Kasl¹

1966

JAMA

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“…This concept of the role of uric acid is applicable for understanding the characteristics of hyperuricemic or gouty humans. Population studies on the characteristics of hyperuricemic and gouty humans showed that such persons are less susceptible to certain kinds of fatigue and show higher activity in drive, achievement, and leadership (BROOKS and MUELLER, 1966;LANESE et al, 1969;MUELLER et al, 1970;KASL et al, 1970a, b;KATZ et al, 1975). All these characteristics of hyperuricemic persons could be understood by the higher activity for energy production.…”

Section: Discussionmentioning

confidence: 99%

Frequent administration of uric acid extends survival of fasting analbuminemic rats under cold environment.

Kawaguchi¹,

Shimode²,

Matsushita³

et al. 1986

Jpn.J.Physiol

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“…Historically, it is interesting to remember how the connection between uric acid and the brain started on a false assumption: in the early 1960s’ the observation that men of genius are frequently troubled with gout led to the hypothesis that this was due to the similarity between uric acid and purines, thus stimulating the cerebral cortex [51]. However, the subsequent research found a significant but very low correlation between intelligence (indexed by the IQ) and serum uric acid levels [52-55]. Therefore, current guidelines do not recommend to treat asymptomatic hyperuricemia to slow the progression of chronic kidney disease or CKD (“There is insufficient evidence to support or refute the use of agents to lower serum uric acid concentrations in people with CKD and either symptomatic or asymptomatic hyperuricemia in order to delay progression of CKD.…”

Section: Urate-lowering Therapy (Ult)mentioning

confidence: 99%

Urate-Lowering Agents in Asymptomatic Hyperuricemia: Role of Urine Sediment Analysis and Musculoskeletal Ultrasound

Viggiano

Gigliotti²,

Vallone

et al. 2018

Kidney Blood Press Res

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Current urate-lowering therapy (ULT) includes three direct acting drugs (allopurinol, febuxostat, Rasburicase) and at least four ‘indirect’ drugs with other important targets (canagliflozin, losartan, fenofibrate and sevelamer). Moreover, the alcalinization of urines using bicarbonate can be used to dissolve urate crystals and the clinician may discontinue several drugs are known to increase serum levels of uric acid, such as diuretics, aspirin, cyclosporine, theophylline, mycophenolate and ACE inhibitors. While there is a consensus to start ULT in cases of symptomatic hyperuricemia (gout, urate-nephrolithiasis), the very frequent conditions of asymptomatic hyperuricemia remains a major conundrum. The effect of asymptomatic hyperuricemia on kidney function has had fluctuating positions over decades. The conflicting results might indicate: (i) the presence of counterbalancing positive and negative effects on kidney function of both serum uric acid and urate-lowering agents, (ii) the presence of a subpopulation of patients, as yet unidentified, which could truly benefit from a urate-lowering therapy. Therefore, today the treatment of asymptomatic hyperuricemia is not recommended nor excluded by current guidelines. Here we suggest that a possible guide for the treatment of asymptomatic hyperuricemia might be the presence of urate crystals in the urine sediment and/or signs of asymptomatic articular damage by urates, identified by musculo-skeletal ultrasound. Moreover, a watchful analysis of the trend in creatinine/eGFR, proteinuria or urate levels might also guide the clinician. Initiation of ULT and follow-up in cases of asymptomatic hyperuricemia should consider urine sediment analysis, musculoskeletal ultrasound and trends in creatinine, proteinuria and serum urate levels.

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Serum Urate Concentrations Among University Professors

Cited by 84 publications

References 11 publications

Serum Urate Concentrations in Male High-School Students

Serum Urate Concentrations in Male High-School Students

Frequent administration of uric acid extends survival of fasting analbuminemic rats under cold environment.

Urate-Lowering Agents in Asymptomatic Hyperuricemia: Role of Urine Sediment Analysis and Musculoskeletal Ultrasound

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