Serum urea and total cholesterol independently predict re-hospitalisation with a cardiac-related event following an acute ST-elevation myocardial infarction

Gruber, Andreas; Smith, Rebecca; Barker, Barbara; Sithole, Jabulani; Thomson, GA; Idris, Iskandar

doi:10.1016/j.ejim.2007.02.032

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…The study of Gruber et al (2007) which analized risk factors of secondary cardiac hospitalizations after acute STEMI showed that high total cholesterol and urea levels on admission were strongly related to MACE development. Elevated initial total cholesterol levels in our study had also a significant relation to MACE rates.…”

Section: Discussionmentioning

confidence: 99%

Relationship between cardiovascular evaluation data on admission and secondary adverse cardiac event rate after acute coronary syndrome

Civan¹,

Özcan²,

Zıyrek³

et al. 2014

jecm

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Article HistoryReceived 30 / 10 / 2013 Accepted 08 / 06 / 2014The current study aimed to investigate the relationship of clinical data with mean platelet volume (MPV) and QT dispersion values on admission of acute coronary syndrome (ACS) patients to the adverse cardiac event rate in a follow-up period of 20 months after discharge. For this purpose demographic and clinical data with corrected QT dispersion on admission and MPV values of 97 consequtive patients with ACS were recorded, retrospectively. Their history of major adverse cardiac event (MACE) in a 20 months period after ACS was obtained from the hospital records, interviews with the attending physicians and telephone calls to patients. Demographic and clinical data with corrected QT dispersion on admission, and MPV values were compared between groups with and without MACE in terms of statistical significance. In our study, diabetesmellitus, left ventricular ejection fraction (EF) and wall motion score index (WMSI), corrected QT dispersion, total cholesterol, LDL, CK-MB and troponin levels were found significantly related to the secondary MACE rate (p values; 0.046, 0.0001, 0.0001, 0.032, 0.024, 0.002 and 0.0001, respectively). No significant relation was detected between groups with and without MACE in terms of conservative medical follow-up and revascularization history (p=0.774). In the comparison of mean MPV values, there was no statistically significant difference between MPV values of patients with MACE (10.4±1.8 fl) and without MACE (10.3±2 fl) (p=0.799). In addition, the subgroup analysis on acute ST-elevation myocardial infarction cases in our study group did not state a significant relationship between MPV values below/above 10.3 fl and MACE rates (p=0.774). Finally, this retrospective study showed that corrected QT dispersion, diabetes, contractile reserve of left ventricule, total and LDL-cholesterol and peak cardiac enzyme values assessed during ACS might predict MACE.

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Section: Discussionmentioning

confidence: 99%

Relationship between cardiovascular evaluation data on admission and secondary adverse cardiac event rate after acute coronary syndrome

Civan¹,

Özcan²,

Zıyrek³

et al. 2014

jecm

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show abstract

“…We have previously shown that elevated serum urea is associated with increased short-term mortality following an ST elevation myocardial infarction 1 . Little is known, however, about its role as a predictor of short-term mortality following an acute stroke.…”

Section: Dear Editormentioning

confidence: 96%

“…We have previously shown that the prognostic value of raised serum urea post-myocardial infarction is independent of serum creatinine and other biochemical parameters. 1 In addition to reflecting GFR, an increased serum urea may also reflect a state of renal hypoperfusion…”

Section: Dear Editormentioning

confidence: 99%

Effects of admission serum urea, glomerular filtration rate, proteinuria and diabetes status on 3-month mortality after acute stroke

Idris

Hill

Sharma

2010

Diabetes and Vascular Disease Research

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“…Koncentrace urey je kromě změn úrovně GF v těchto stavech také obrazem zapojení dalších mechanismů (aktivace sympatiku a systému renin-angiotensin-aldosteron) [17]. Dalším faktorem, který nezávisle zvyšuje koncentraci urey, je použití diuretik z důvodu konkomitantního srdečního selhání, jež je rovněž nepříznivým prognostickým ukazatelem u pacientů s AKS [18]. V pracích zabývající se rizikovou stratifi kací pacientů s AKS pomocí laboratorních markerů je urea oproti kreatininu a GF využívána mnohonásobně méně.…”

Section: Ureaunclassified

“…V pracích zabývající se rizikovou stratifi kací pacientů s AKS pomocí laboratorních markerů je urea oproti kreatininu a GF využívána mnohonásobně méně. Je však prokázána nezávislá (na GF, ale i dalších faktorech) korelace urey a krátkodobé [19] i dlouhodobé [17] mortality pacientů s AKS a také s výskytem některý komplikací [18]. Stanovení urey tedy přináší přidanou informaci ke vstupní sérové koncentraci kreatininu s akcentací využití v některých výše zmíněných specifi ckých hemodynamických situacích.…”

Section: Ureaunclassified

Biomarkers of renal function in prognostic stratification of patients with acute coronary syndrome

et al. 2018

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Mezi ledvinami a srdcem probíhá těsná patofyziologická interakce, která mimo jiné ovlivňuje riziko vzniku i prognózu mnoha kardiovaskulárních onemocnění. Časná riziková stratifi kace pacientů s akutním koronárním syndromem (AKS) je důležitá pro optimalizaci terapie. V předloženém přehledu jsou uvedeny možnosti prognostické stratifi kace pacientů s AKS na základě vstupních koncentrací biomarkerů renálních funkcí. Zmíněny jsou klasické biomarkery (kreatinin, urea), které mají dominantní význam spíše již u rozvinutého chronického onemocnění ledvin, a také některé novější biomarkery (cystatin C, NGAL, interleukin 18), které přinášejí přidanou hodnotu díky přesahu těchto biomarkerů přímo do patofyziologických mechanismů průběhu AKS.

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Serum urea and total cholesterol independently predict re-hospitalisation with a cardiac-related event following an acute ST-elevation myocardial infarction

Cited by 4 publications

References 14 publications

Relationship between cardiovascular evaluation data on admission and secondary adverse cardiac event rate after acute coronary syndrome

Relationship between cardiovascular evaluation data on admission and secondary adverse cardiac event rate after acute coronary syndrome

Effects of admission serum urea, glomerular filtration rate, proteinuria and diabetes status on 3-month mortality after acute stroke

Biomarkers of renal function in prognostic stratification of patients with acute coronary syndrome

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