Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study

Cheng, Di; Hu, Chunyan; Du, Rui; Qi, Hongyan; Lin, Lin; Wu, Xinyuan; Ma, Lina; Peng, Kui; Li, Mian; Xu, Min; Xu, Yu; Bi, Yufang; Wang, Weiqing; Chen, Yuhong; Lu, Jieli

doi:10.1007/s11684-019-0723-7

Cited by 11 publications

(14 citation statements)

References 34 publications

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“…High UA is a strong and independent predictor of MetS and is associated with impaired fasting glucose and insulin resistance. 46 , 47 , 48 A recent 6-h TRE trial in overweight individuals with prediabetes revealed an improvement in insulin sensitivity and β cell responsiveness but no reduction in FBG. 19 Fasting might improve glycemic control as a result of metabolic switch from liver-derived glucose to adipose cell-derived ketones, occurring when switching from a fed to a fasted state, and it might induce ketoplasia, decrease fat accumulation, and increase insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial

He¹,

Wang²,

Liang³

et al. 2022

Cell Reports Medicine

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Section: Discussionmentioning

confidence: 99%

Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial

He¹,

Wang²,

Liang³

et al. 2022

Cell Reports Medicine

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“…[ 36 ] Furthermore, these gender-specific associations of UA were also observed in other studies. [ 4 9 10 37 ] Dyslipidemia (elevated LDL, elevated TG, and low level of HDL) and HbA1c were highly correlated with UA. Our data support other recent reports on the UA levels in Saudi females with diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Several ingestions have been carried out in different populations to assess the prevalence of serum UA in different groups and establish whether an association exists between serum UA with various chronic diseases. [ 2 3 4 5 6 7 8 9 10 ] It has been reported that serum UA content >6.57 mg/dL increases the risk of all-cause mortality. [ 11 ] It has been reported that elevated serum UA is associated with cardiovascular disease, hypertension, and chronic kidney disease.…”

Section: Introductionmentioning

confidence: 99%

Association between serum uric acid with diabetes and other biochemical markers

Alasmary

Alqahtani

Awan³

et al. 2022

Journal of Family Medicine and Primary Care

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Objective: This study aimed to decipher the association between serum uric acid (UA) and glycated hemoglobin (HbA1c) in the population from the southern region of Saudi Arabia. Method: In this retrospective cross-sectional investigation, clinical data obtained from the different commercial laboratories in the Asir region of Saudi Arabia were screened over 2 years. Data were analyzed using standard statistical methods. Results: A total of 1984 laboratory investigations with 1215 females (61.2%) and 769 males (38.6%) were included in the data analysis. In our investigation, the prevalence of hyperuricemia in the study population was 53.5% (41.2% females and 12.3% males) and in the diabetic population was 12.7% (9.47% females and 3.23% males), in prediabetics was 12.65% (9.8% females and 2.85% males), respectively. Prediabetic subjects had higher UA levels than people with diabetes or healthy people. Higher UA quartiles were associated with a high level of urea, blood urea nitrogen (BUN) creatinine, HbA1c, fasting blood sugar (FBS), and total cholesterol (TC) ( P < 0.05). High UA (OR = 1.33 for diabetes; OR = 2.676 for prediabetes), high BUN (OR = 3.05 for diabetes; OR = 2.293 for prediabetes), high TC (OR = 3.75 for diabetes; OR = 1.098 for prediabetes), and high TG (OR = 2.67 for diabetes; OR = 1.943 for prediabetes) parameters are the most influential risk factor in diabetic and prediabetic patients than the people who have normal UA, BUN, TC, and TG value. Conclusion: High UA levels are significantly associated with prediabetes as defined by HbA1c criteria, indicating that UA has a significant role in the disturbance of glucose metabolism. A significant positive association was observed between dyslipidemia and serum UA in the study population.

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“…Hemoglobin A1c (HbA1c), a marker of glycemic control within the prior two to three months, has become a diagnosis index of diabetes [ 9 ]. Although there have been some studies indicating that high SUA levels are associated with an increased risk of incident T2DM [ 4 ], especially in women [ 10 , 11 ], research exploring SUA levels and glycemic control (HbA1c) was limited, and reported contradictory results. One study of 23,933 subjects coming from physical examinations indicated that increased SUA levels lowered the risk of elevated HbA1c(> 6.5%) [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid

Ying

Wang

et al. 2022

Diabetol Metab Syndr

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Background Hemoglobin glycation index (HGI), which is calculated by blood glucose and hemoglobin A1c(HbA1c), reflects the individual discrepancy in HbA1c. This study aimed to investigate the association between HGI/HbA1c and serum uric acid(SUA) stratified by sex and diabetes. Methods The study recruited 33772 participants who underwent physical examinations between April 2016 and August 2021 in Beijing Chao-Yang Hospital. A random subsample of 3000 subjects was utilized to calculate the formula of HGI and data of the remaining 30772 participants were used for analysis. HGI and HbA1c were categorized according to quartiles (Q1, Q2, Q3, Q4), using Q1 as the reference. We used multiple linear regression and restricted cubic splines for data analysis. Results 30772 participants with a mean age of 44.4 years old were included in the analysis, 48.6% (N = 14944) of which were female and 7.7% (N = 2363) with diabetes. Associations of HGI, HbA1c and SUA were modified by sex and diabetes. The relationship between SUA levels and HGI was positive in women without diabetes, with one unit increase in HGI associating with an 11.3 μmol/L increase in SUA (P < 0.001) after adjusting for other confounders. On average, each one-unit increase in HbA1c was associated with a 14.3 μmol/L decrease in SUA in women with diabetes, a 14.9 μmol/L decrease in SUA in men with diabetes, and a 16.5 μmol/L increase in SUA in women without diabetes (all P < 0.001). The SUA levels in men without diabetes showed a bell-shaped relation with HbA1c, increasing as the HbA1c rose to around 5.7% and then falling with a further increase of HbA1c (P < 0.001). Conclusions SUA levels were inversely correlated with HbA1c in diabetic patients, also in men with prediabetes (HbA1c ≥ 5.7%), but positively correlated with HbA1c and HGI in women without diabetes. Glycemic control may help to reduce the risk of hyperuricemia in non-diabetes women.

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Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study

Cited by 11 publications

References 34 publications

Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial

Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial

Association between serum uric acid with diabetes and other biochemical markers

Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid

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