2015
DOI: 10.1210/jc.2015-2527
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Serum Uric Acid Levels and Risk of Metabolic Syndrome: A Dose-Response Meta-Analysis of Prospective Studies

Abstract: This meta-analysis suggests that higher SUA levels led to an increased risk of MS regardless of the study characteristics, and were consistent with a linear dose-response relationship. In addition, SUA was also a causal factor for the NAFLD risk.

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Cited by 205 publications
(157 citation statements)
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“…Since increased SUA has been consistently shown to be associated with insulin resistance, components of MetS, CVD and renal diseases5619 and all these conditions are also independently associated with NAFLD, interests to explore the association between SUA and NAFLD have grown. Lonardo et al .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Since increased SUA has been consistently shown to be associated with insulin resistance, components of MetS, CVD and renal diseases5619 and all these conditions are also independently associated with NAFLD, interests to explore the association between SUA and NAFLD have grown. Lonardo et al .…”
Section: Discussionmentioning
confidence: 99%
“…SUA has been consistently shown to be associated with hypertension, insulin resistance, abdominal obesity and dyslipidemia, a cluster of metabolic disorders that is identified as metabolic syndrome (MetS)56. Since NAFLD has also been regarded as a hepatic manifestation of MetS, growing interests have focused on the relationship between SUA and NAFLD.…”
mentioning
confidence: 99%
“…Hyperuricemia was reportedly found to be related to insulin resistance in several clinical analyses [146152]. In addition, several meta-analyses have suggested the UA level to be positively associated with the development of type 2 diabetes mellitus (DM) [153156], although Mendelian randomization studies did not support circulating UA as being among the causes of DM development [157, 158].…”
Section: Ua Metabolism and Chronic Renal Disease Atherosclerosismentioning
confidence: 99%
“…The RR of each 5 μg/ml adiponectin level increment was calculated for studies that provided enough raw data to quantify the association between adiponectin level and risk of stroke using GLST (generalized least-squares trend estimation) and VWLS (variance-weighted least square regression model) for the dose-response analysis, as proposed by Greenland, Longnecker, Orsini et al . The detailed methods of the dose-response meta-analysis have been described before18.…”
Section: Methodsmentioning
confidence: 99%