Serum uric acid, serum glucose and diabetes: relationships in a population study

Cook, Derek G; Shaper, A. G.; Thelle, Dag S.; Whitehead, T. P.

doi:10.1136/pgmj.62.733.1001

Cited by 143 publications

(100 citation statements)

References 13 publications

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“…Moreover, higher urate concentrations in prediabetic compared with non-diabetic subjects have also been reported." This work was indirectly confirmed by Cook et al,5 who showed that in a population study of men the mean urate concentrations increased with increasing mean glucose concentration until a mean glucose of approximately 8 mmollL was reached, after which the urate value did not increase further. Then as the mean glucose value increased above 10 mmollL there was a significant decrease in urate concentrations.…”

supporting

confidence: 74%

Serum Urate, Serum Glucose and Diabetes

Whitehead¹,

Jungner²,

Robinson³

et al. 1992

Ann Clin Biochem

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SUMMARY. We have studied the relationship between serum glucose and urate in 260 699 men and 214 118 women from Sweden, and 140084 men and 30653 women from the UK. We found an increase in mean serum urate with increasing glucose concentrations up to 7'OmmollL in men and 9'OmmollL in women. Thereafter increasing glucose values were accompanied by a statistically significant decrease in urate concentrations. This fall was particularly marked in younger subjects. We believe this may have important implications for the free radical status of diabetics. Additional key phrases: diabetics; glycosuria; free radicalsRelationships between serum urate and glucose in patients with diabetes have been reported over three decades.l " All the authors conclude that in diabetes the serum urate concentration is reduced. Moreover, higher urate concentrations in prediabetic compared with non-diabetic subjects have also been reported." This work was indirectly confirmed by Cook et al.,5 who showed that in a population study of men the mean urate concentrations increased with increasing mean glucose concentration until a mean glucose of approximately 8 mmollL was reached, after which the urate value did not increase further. Then as the mean glucose value increased above 10 mmollL there was a significant decrease in urate concentrations. They postulated that the fall in urate concentrations occurred when the serum glucose concentration rose to a value which resulted in glycosuria. It has been shown in healthy volunteers" that if the serum glucose is raised above that sufficient to cause glycosuria, then urinary urate is directly proportional to the urinary glucose. METHODSTo study this problem we have been able to use large data bases of laboratory results from Sweden and the UK. The Swedish results were from a group of patients numbering 260 699 men and 214118 women. Most of the specimens Correspondence: Dr Ann Hale.analysed were from subjects having routine health assessments but some were from known diabetics. There were 9415 (3 '60/0) men with serum glucose concentrations of 7· 5 mmollL or greater. The corresponding figure for women was 4048 (1' 9%).The patients in the UK study were attending the BUP A Health Screening Centres in London, the analyses being carried out by J S Pathology Pic (London, UK). The results from 140084 men have been analysed and 1936 (1'4%) had serum glucose concentrations of at least 7· 5 mmollL. The corresponding figure for women was 30653 of whom 220 (0' 7%) had a serum glucose of 7· 5 mmollL or greater.The specimens were separated within 1 h of collection. The serum glucose method using glucose oxidase was the same in both countries, but the urate methods were different. In the UK the phosphotungstic acid method was used, employing the SMAC II analyser of the Technicon Company (Basingstoke, UK) and in Sweden the uricase method marketed as a diagnostic kit by Boehringer Mannheim (Tutzing, Germany) was used, the apparatus employed being a PRISMA Multichannel Analyser (New Clinicon, Stockholm, Sweden). We ...

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supporting

confidence: 74%

Serum Urate, Serum Glucose and Diabetes

Whitehead¹,

Jungner²,

Robinson³

et al. 1992

Ann Clin Biochem

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“…Cook et al explained higher mean serum uric acid values in prediabetic patients than in recently diagnosed diabetics and lower values in diabetics. The negative association could be due to the increased excretion of uric acid during hyperglycemia and glycosuria [19]. In this study, triacylglycerol was increased in 46% of the total diabetic people.…”

Section: Discussionmentioning

confidence: 70%

Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

Parajuli

Shakya

Pardhe

et al. 2017

Ann. Clin. Chem. & Lab. Med.

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“…GLU, as the sole nitrogen and carbon source, is in dynamic equilibrium in the human body and remains relatively constant under normal circumstances. The levels of GLU also have been shown to influence renal uric acid excretion during hyperglycemia and glycosuria (Christensen and Steenstrup, 1958;Cook et al, 1986). Interestingly, relationships have previously been observed between serum UA and serum glucose in subjects with gout (Beckett and Lewis, 1960).…”

Section: Discussionmentioning

confidence: 94%

PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients

et al. 2016

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ABSTRACT. Previous studies have shown that the PDK2 and ABCG2 genes play important roles in many aspects of gout development in European populations. However, a detailed genotype-phenotype analysis was not performed. The aim of the present study was to investigate the potential association between variants in these two genes and metabolismrelated quantitative phenotypes relevant to gout in a Chinese Tibetan population. In total, 316 Chinese Tibetan gout patients were recruited from rheumatology outpatient clinics and 6 single nucleotide polymorphisms in PDK2 and ABCG2 were genotyped, which were possible etiologic variants as identified in the HapMap Chinese Han Beijing population. A significant difference in blood glucose levels was detected between different genotypes of rs2728109 (P = 0.005) in the PDK2 gene. We also detected a significant difference in the mean serum uric levels between different genotypes of rs3114018 (P = 0.004) in the ABCG2 gene. All P values remained significant after Bonferroni's correction for multiple testing. Our data demonstrate potential roles for PDK2 and ABCG2 polymorphisms in the metabolic phenotypes of Tibetan gout patients, which may provide new insights into the etiology of gout. Further studies are required to confirm these findings.

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Serum uric acid, serum glucose and diabetes: relationships in a population study

Cited by 143 publications

References 13 publications

Serum Urate, Serum Glucose and Diabetes

Serum Urate, Serum Glucose and Diabetes

Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients

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