Serum visfatin concentrations in obese adolescents and its correlation with age and high-density lipoprotein cholesterol

Jin, Hua; Jiang, Boren; Tang, Junling; Lu, Wenli; Wang, Wei; Zhou, Libin; Shang, Wenbin; Li, Fengying; Ma, Q; Yang, Ying; Chen, Ming-Dao

doi:10.1016/j.diabres.2007.09.019

Cited by 76 publications

(83 citation statements)

References 44 publications

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“…Several studies have shown that visfatin is positively correlated with HOMA-IR in children [10,35]. The present study did not report the same findings, but instead found that boys had higher visfatin levels than girls, which is in contrast to previous studies [9,13]. This study included a large homogenous sample, which may explain the difference in results.…”

Section: Discussioncontrasting

confidence: 57%

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Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

Lee

Park

et al. 2013

Endocr J

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Section: Discussioncontrasting

confidence: 57%

“…Visfatin is related to several insulin resistant conditions, such as obesity, metabolic syndrome, and dyslipidemia [9][10][11][12][13][14]. Elevated visfatin concentrations were correlated with body fat mass and visfatin levels decrease when weight loss occurs [13,15].…”

Section: Discussionmentioning

confidence: 99%

Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

Lee

Park

et al. 2013

Endocr J

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“…Subsequent studies have identified visfatin as a nicotinamide phosphoribosyltransferase (NAMPT) capable of producing nicotinamide mononucleotide (NMN), a precursor for the metabolic co-factor NAD C (Kim et al 2006). The circulating levels of visfatin have been reported to be elevated in both obesity and T2D (Li et al 2006, Jin et al 2008, suggesting that in these metabolic disorders, the pancreatic b-cell may be exposed to elevated visfatin levels. As the pancreatic b-cell is known to express the insulin receptor (Muller et al 2006) and the insulin receptor is known to have an essential role in regulating b-cell function (Otani et al 2004), any compound such as visfatin which may interact with insulin signalling could potentially elicit significant regulatory effects.…”

Section: Introductionmentioning

confidence: 99%

Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic β-cells

Brown¹,

Onyango²,

Ramanjaneya³

et al. 2009

Journal of Molecular Endocrinology

108

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The role of the adipocyte-derived factor visfatin in metabolism remains controversial, although some pancreatic b-cellspecific effects have been reported. This study investigated the effects of visfatin upon insulin secretion, insulin receptor activation and mRNA expression of key diabetes-related genes in clonal mouse pancreatic b-cells. b-TC6 cells were cultured in RPMI 1640 and were subsequently treated with recombinant visfatin. One-hour static insulin secretion was measured by ELISA. Phospho-specific ELISA and western blotting were used to detect insulin receptor activation. Real-time SYBR Green PCR array technology was used to measure the expression of 84 diabetes-related genes in both treatment and control cells. Incubation with visfatin caused significant changes in the mRNA expression of several key diabetes-related genes, including marked up-regulation of insulin (9-fold increase), hepatocyte nuclear factor (HNF)1b (32-fold increase), HNF4a (16-fold increase) and nuclear factor kB (40-fold increase). Significant down-regulation was seen in angiotensin-converting enzyme (K3 . 73-fold) and UCP2 (K1 . 3-fold). Visfatin also caused a significant 46% increase in insulin secretion compared to control (P!0 . 003) at low glucose, and this increase was blocked by co-incubation with the specific nicotinamide phosphoribosyltransferase inhibitor FK866. Both visfatin and nicotinamide mononucleotide induced activation of both insulin receptor and extracellular signal-regulated kinase (ERK)1/2, with visfatin-induced insulin receptor/ERK1/2 activation being inhibited by FK866. We conclude that visfatin can significantly regulate insulin secretion, insulin receptor phosphorylation and intracellular signalling and the expression of a number of b-cell function-associated genes in mouse b-cells.

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“…Other research has not observed significant differences between serum VISF concentrations in obese and non-obese individuals [48]. Still others demonstrated a decrease [49] or increase [50][51][52] of serum VISF levels in obese subjects compared to a control group. On the other hand, obese women exhibited a significant reduction in the circulating levels of bone markers, cytokines of the RANKL/RANK/OPG system (especially RANKL) as well as an increase in the OPG/RANKL ratio compared to age-matched lean women [44,45,53,54].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, they did not find differences in VISF mRNA expression between visceral and subcutaneous adipose tissue. Other researchers demonstrated a decrease [49] or increase [50][51][52] of VISF concentrations in obese subjects. According to some authors [43,[85][86][87][88][89][90], the association between LP, ADIPO, RES and VISF and obesity is lent support by changes in adipocytokine concentrations following weight reduction (diet or surgery) in individuals with moderate or severe obesity.…”

Section: Prace Oryginalnementioning

confidence: 99%

Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie

Ostrowska

Świętochowska

Marek

et al. 2015

Endokrynologia Polska

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Selected adipose tissue hormones, bone metabolism, osteoprotegerin and receptor activator of nuclear factor-kB ligand in postmenopausal obese women Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie AbstractIntroduction: It has been suggested that changes in the production of adipose tissue hormones in obese postmenopausal women might affect their bone status. The aim of this study was to determine whether obese postmenopausal women exhibited any relationship between serum levels of LP, ADIPO, RES, VISF, APE and bone metabolism markers (OC and CTx), OPG, sRANKL, the OPG/sRANKL ratio as well as BMD. Material and methods: 80 postmenopausal women (60 obese and 20 healthy) underwent BMD measurement using dual-energy X-ray absorptiometry (DXA) at lumbar spine L 2 -L 4 . Serum levels of selected adipose tissue hormones, OC, CTx, OPG and its soluble ligand, sRANKL, were assessed by ELISA. Results:Obese postmenopausal women demonstrated a significant increase in body mass, BMI and WHR associated with significant increases in LP and RES levels, a decrease in ADIPO concentration, suppression of OC, CTx, OPG and sRANKL and an increase in the OPG/sRANKL ratio and BMD. BMI correlated positively with BMD, LP, RES, OPG and the OPG/sRANKL ratio, whereas in the case of ADIPO, OC, CTx, sRANKL the relationship was negative. WHR was positively correlated with the OPG/sRANKL ratio, and negatively with ADIPO and APE. A positive correlation was found between BMD and LP, APE and the OPG/sRANKL ratio, while the correlation between BMD and ADIPO, CTx, sRANKL was negative. Significant positive correlations were also revealed between OC, CTx and ADIPO; OPG and ADIPO; sRANKL and ADIPO, RES; the OPG/sRANKL ratio and LP. OC correlated negatively with LP, RES, VISF, APE; CTx with LP, VISF, APE; OPG with LP; sRANKL with LP and APE; the OPG/sRANKL ratio with VISF. ADIPO was an independent predictor of OC, OPG and sRANKL, while LP turned out to be an independent predictor of CTx, OPG, sRANKL and the OPG/sRANKL ratio. Conclusions: Obesity in postmenopausal women can lead to changes in BMD, circulating levels of bone markers, OPG, sRANKL and/or the OPG/sRANKL ratio; these changes are associated with alterations in the concentrations of adipose tissue hormones under investigation. The relationships between bone status indicators and adipose tissue hormones, especially LP and ADIPO, seem to suggest that changes in these hormones observed in obese postmenopausal women might have a protective effect on bone tissue, most probably via a shift in the OPG/sRANKL ratio towards a functional excess of OPG. (Endokrynol Pol 2014; 65 (6): 438-448)

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Serum visfatin concentrations in obese adolescents and its correlation with age and high-density lipoprotein cholesterol

Cited by 76 publications

References 44 publications

Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic β-cells

Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie

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