Serum Vitamin B12 Levels and Vitamin B12 Binding Capacity in Pregnant and Non-pregnant Europeans and West Indians

Low-Beer, T S; McCarthy, C. F.; Austad, W. I.; Brzechwa-Ajdukiewicz, A; Read, A. E.

doi:10.1136/bmj.4.5624.160

Cited by 18 publications

(9 citation statements)

References 7 publications

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“…Our results on the serum UB12BC are quite high (mean -1,478 pg/ml) and they correlate very well with results obtained in African adults [14][15][16] and adult West Indi ans [17]. In all available reports, the mean serum UB12BC and B12 levels of the black are significantly higher than that of the white race [15][16][17] [19][20][21], All these obser vations lead one to conclude that the syn thesis of serum UB12BC may be under some genetical control.…”

Section: Discussionsupporting

confidence: 75%

“…This result is in agree ment with what was observed in children of mixed race in South Africa [8], where /i-binder accounted for 48% of the serum UB,2BC. On the other hand, the percen tage of TC II in our children is low com pared with what has been reported on Afri can adults where TC II accounts for about 70% of their scrum UB,2BC [14,16,17]. Throughout this study, we observe a strong inverse relationship between TC I and TC II.…”

Section: Discussionsupporting

confidence: 50%

“…In all available reports, the mean serum UB12BC and B12 levels of the black are significantly higher than that of the white race [15][16][17] [19][20][21], All these obser vations lead one to conclude that the syn thesis of serum UB12BC may be under some genetical control.…”

Section: Discussionmentioning

confidence: 99%

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Serum Transcobalamins in Healthy Nigerian Children

Osifo¹,

Parmentier²,

Gérard³

et al. 1982

Acta Haematol

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The unsaturated vitamin B₁₂-binding capacity (UB₁₂BC) and the three transcobalamins (TC I, TC II, TC III) have been studied in the serum of normal healthy Nigerian children. The serum UB₁₂BC level was very high in the children: TC I accounted for 39.5% of UB₁₂BC, TC II accounted for 49.5% and TC III accounted for 11%. The results are discussed in the light of the variations in the distribution of transcobalamins in children from what has been previously reported among the African adults. The high percentage of TC I in the children is discussed in the light of a possible immunological role of this trans-cobalamin. There was an inverse relationship between TC I and TC II levels. A sex difference in UB₁₂BC and TC I levels was observed. The girls had higher UB₁₂BC and this was due to higher TC I, but the advantage of this is not clear.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 50%

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Serum Transcobalamins in Healthy Nigerian Children

Osifo¹,

Parmentier²,

Gérard³

et al. 1982

Acta Haematol

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“…Since many Indian subjects consuming a vegetarian diet usually have distinctly low serum vitamin B12 levels, it is not surpris ing that pregnant women in this study had considerably lower plasma vitamin B12 val ues as compared to those reported from the Western countries [4,8]. A remarkably high incidence of subnormal serum vitamin B12 levels in pregnant Indian women migrated to England has been reported by Roberts et al [12], Thus, of the 320 patients tested, 35% showed subnormal levels and these were most frequent in Indians.…”

Section: Discussionmentioning

confidence: 39%

“…Despite the distinctly low plasma vitamin B12 values, the Indian lactovegetarians have an erythrocyte vitamin B12 content comparable to that observed in nonvegetarians belonging to the same popu lation [5]. Serum vitamin B12 levels usually show a fall during normal pregnancy [8,9,11,12] and high incidence of subnormal serum vitamin B12 levels has been reported in Indian pregnant women who emigrated to England [12]. However, little is known about the behaviour of the erythrocyte vitamin B12 content during pregnancy in Indian women consuming very little meat, fish, or similar nonvegetarian food.…”

mentioning

confidence: 99%

Erythrocyte Vitamin B<sub>12</sub> Activity in Lactovegetarian Pregnant Indian Women

Jathar¹,

Inamdar-Deshmukh²

1981

Acta Haematol

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Plasma and erythrocyte vitamin B₁₂ levels were studied in pregnant Indian women consuming very little food of animal origin and compared with healthy non-pregnant women from the same dietetic group. The comparison of the mean values for routine haematological parameters revealed distinct fall in haemoglobin, packed cell volume, plasma vitamin B₁₂, and albumin levels in pregnant women. However, the mean erythrocyte vitamin B₁₂ levels in pregnant women with haemoglobin of more than 10 g/dl did not differ significantly from the corresponding mean observed in non-pregnant subjects. It seems that in normal pregnancy, the fall in erythrocyte vitamin B₁₂ is much less marked than the fall in plasma levels of this vitamin.

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Sex difference in the progression of manic symptoms during acute hospitalization: A prospective pilot study

Abulseoud

Şenormancı

et al. 2020

Brain and Behavior

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Objectives Acute mania is a serious medical condition that impacts men and women equally. Longtime presentation of manic symptoms is sex‐dependent; however, little is known about acute symptoms of mania. The objective of this study is to track and compare acute manic symptoms for sex differences during inpatient hospitalization. Methods All patients with bipolar mania admitted to a large university hospital between January and October 2017 were invited to participate in this longitudinal naturalistic follow‐up study. Manic (YMRS), depressive (MADRS), and psychotic (PAS) symptoms were tracked daily from admission to discharge. Results The total YMRS scores decreased significantly overtime (p < .0001) in both male (n = 34) and female (n = 23) patients (p = .7). However, male patients scored significantly higher in sexual interest (p = .01), disruptive and aggressive behavior (p = .01), and appearance (p < .001) while females had better insight into their illness (p = .01). Males and females received similar doses of lithium (p = .1), but males received significantly higher doses of valproic acid (VPA) in comparison with females (p = .003). However, plasma lithium and VPA concentrations at discharge were not significantly different between sexes. Conclusion Our results show sex differences in the progression of certain domains of manic symptoms in a cohort of 23 female and 34 male patients admitted to a large academic center in Turkey. Males, in this sample, exhibited more sexual interest, disruptive and aggressive behaviors, better grooming, and less insight compared to females. While these results are concordant with our preclinical findings and with anecdotal clinical observations, replication in larger samples is needed.

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Serum Vitamin B12 Levels and Vitamin B12 Binding Capacity in Pregnant and Non-pregnant Europeans and West Indians

Cited by 18 publications

References 7 publications

Serum Transcobalamins in Healthy Nigerian Children

Serum Transcobalamins in Healthy Nigerian Children

Erythrocyte Vitamin B<sub>12</sub> Activity in Lactovegetarian Pregnant Indian Women

Sex difference in the progression of manic symptoms during acute hospitalization: A prospective pilot study

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