Serum vitamin D and parathyroid hormone profiles in patients with various stages of renal disease

Abdel-Gayoum, Abdelgayoum Ahmed

doi:10.4066/amj.2015.2252

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…The average age of participants in the MESA (62 years) was markedly higher than in ARICs (range: 56–57 years) and PREVENDs (49 years). In general, kidney function declines with age and changes in PTH levels are predominantly present in patients with advanced stages of chronic kidney disease . Independent from kidney function, increasing age itself is associated with increased plasma PTH concentrations, and it has even been suggested to take this effect into account when assessing calcium disorders in elderly individuals .…”

Section: Discussionmentioning

confidence: 99%

Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population‐based cohort study

et al. 2016

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BackgroundHeart failure (HF) is a major problem in the Western world, with increasing prevalence and incidence. Because HF cannot be cured, prevention of HF is of utter importance. Calcidiol, calcitriol, and parathyroid hormone (PTH) have been identified as risk factors for cardiovascular disease. However, their association with new onset HF remains to be established. We investigated whether calcidiol, calcitriol, and PTH could be used to identify those subjects at risk for new onset HF, and if they had additive predictive value over established risk predictors like N‐terminal‐pro Brain‐type natriuretic peptide and highly sensitive Troponin‐T.Methods and resultsWe examined 7470 HF‐free participants in Prevention of Renal and Vascular End‐stage Disease, a community‐based cohort study in Groningen, the Netherlands (latitude 53°N, mean age: 49 years, 48% male). During follow‐up time of 12.6 years (interquartile range: 12.3–12.9), 281 participants (4%) developed HF: 181 (66%) HF with reduced and 94 (34%) HF with preserved ejection fraction (HFrEF [left ventricular ejection fraction ≤ 40%], and HFpEF [left ventricular ejection fraction ≥ 50%], respectively). Mean (±SD) of calcidiol was 58 (±24) nmol/L, mean calcitriol 145 (±48) pmol/L, and median (interquartile range) PTH was 3.7 (3.0–4.6) pmol/L. Calcidiol levels were univariately associated with new onset HF [hazard ratio (HR) 0.82 (95% CI 0.69–0.96)], but calcitriol levels were not [HR 0.85 (95% CI 0.71–1.03)]. PTH levels kept their predictive value after adjustment for age, sex, and day of blood withdrawal (HR 1.26 [95% CI 1.04–1.53]). However, in our full model this association was lost [HR 1.10 (95% CI 0.92–1.32)]. Calcidiol, calcitriol, and PTH could not differentiate between new onset HFrEF or HFpEF.ConclusionsAfter adjustment for confounding factors, a single measurement of plasma calcidiol, calcitriol, or PTH was not associated with risk of developing HF. Screening for these markers to identify subjects at risk for new onset HF cannot be advocated.

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Section: Discussionmentioning

confidence: 99%

Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population‐based cohort study

et al. 2016

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“…Also, creatinine was measured as it is negatively correlated with vitamin D levels. 19 Renal function was assessed by measurement of serum creatinine by automated spectrophotometry (Wiener Laboratory, Rosario, Santa Fe, Argentina). Serum 25(OH)D was determined by a chemiluminescence immunoassay using the LIAISON 25 OH Vitamin D TOTAL assay (DiaSorin, Saluggia, Italy).…”

Section: Methodsmentioning

confidence: 99%

Does the Access to Sun Exposure Ensure Adequate Levels of 25-Hydroxyvitamin D?

Damaso

Paula

Franceschini

et al. 2017

Rev Bras Ginecol Obstet

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Objectives To assess the prevalence of hypovitaminosis D, altered arterial blood pressure, and serum levels of glucose and lipids in community-dwelling women in the city of Ribeirão Preto, in the southeast of Brazil. Methods This was a cross-sectional study of women aged 40-70 years old. Calcium intake and level of sun exposure were assessed by means of a questionnaire. A blood sample was used to determine glucose, lipid profile and 25-hydroxyvitamin D (25[OH]D) concentration. Results Ninety-one women were enrolled (age ¼ 54.2 AE 7.1 years). The mean serum 25(OH)D concentration was 25.7 AE 8.9 ng/mL. A total of 24 (26.4%) women had 25 (OH)D levels < 20 ng/mL. Seventy women (76.9%) had 25(OH)D levels < 30 ng/mL. Seventy-five women (90.4%) had inadequate calcium intake, and 61 women (67%) had appropriate sun exposure, 49 of whom (80.3%) had serum 25(OH)D levels < 30 ng/mL. Conclusion This study indicates that even in community-dwelling women, living in a city with high sun exposure, serum levels of 25(OH)D > 30 ng/ml are hardly reached. Thus, it is probable that other intrinsic factors besides sun exposure may regulate the levels of vitamin D. Palavras-chave ResumoObjetivos Estimar a prevalência de hipovitaminose D, hipertensão arterial, e níveis séricos de glicose e perfil lipídico em uma comunidade de mulheres de Ribeirão Preto, no Sudeste brasileiro. Métodos Estudo transversal com mulheres de 40 a 70 anos de idade, submetidas a um questionário para determinar ingestão diária de cálcio e nível de exposição solar, e coleta de sangue para determinar glicose, perfil lipídico e concentração de 25-hidroxivitamina D (25[OH]D).Resultados Noventa e uma mulheres foram incluídas (idade ¼ 54,2 AE 7,1 anos). O nível sérico médio de 25(OH)D foi 25,7 AE 8,9 ng/mL. Um total de 24 (26,4%) mulheres

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Assessment of bone turnover markers to predict mineral and bone disorder in men with pre-dialysis non-diabetic chronic kidney disease

Davina

Priyadarssini

Rajappa

et al. 2017

Clinica Chimica Acta

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Serum vitamin D and parathyroid hormone profiles in patients with various stages of renal disease

Abstract: RESEARCHPlease cite this paper as: Abdel-Gayoum AA. Serum vitamin D and parathyroid hormone profiles in patients with various stages of renal disease. AMJ 2015;8(2):33-40. http://dx. ABSTRACT Background

Cited by 5 publications

References 42 publications

Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population‐based cohort study

Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population‐based cohort study

Does the Access to Sun Exposure Ensure Adequate Levels of 25-Hydroxyvitamin D?

Assessment of bone turnover markers to predict mineral and bone disorder in men with pre-dialysis non-diabetic chronic kidney disease

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