Serum Vitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer

Anic, Gabriella M.; Weinstein, Stephanie J.; Mondul, Alison M.; Männistö, Satu; Albanês, Demetrius

doi:10.1371/journal.pone.0102966

Cited by 36 publications

(41 citation statements)

References 43 publications

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“…Two previous studies have assessed circulating VDBP in relation to CRC incidence. (10, 11) In line with our results, neither of the studies found an association between VDBP and CRC risk. Interestingly, one study of male smokers found that total 25(OH)D was associated with higher risk of CRC among individuals with high VDBP, with no association among those with low VDBP.…”

Section: Discussionsupporting

confidence: 88%

“…Interestingly, one study of male smokers found that total 25(OH)D was associated with higher risk of CRC among individuals with high VDBP, with no association among those with low VDBP. (11)…”

Section: Discussionmentioning

confidence: 99%

“…The only two prospective studies so far have not detected an association between circulating VDBP and CRC risk. (10, 11) However, these studies lacked information on both genetic determinants of VDBP binding affinity and levels of albumin, precluding a more complete evaluation of the influence of free or bioavailable 25(OH)D on CRC risk.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study

Song

Konijeti

Yuan

et al. 2016

Cancer Prevention Research

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Total circulating 25-hydroxyvitamin D [25(OH)D)] has been associated with lower risk of colorectal cancer (CRC). The physiologic mechanism, however, may be more directly related to the free or bioavailable fraction of 25(OH)D, which is influenced by levels of vitamin D binding protein (VDBP). We assessed the association of prediagnosis total, free and bioavailable 25(OH)D and VDBP with CRC risk among predominantly white women in the Nurses’ Health Study (NHS) who provided a blood specimen in 1989–1990. We documented 378 cases of CRC through 2011 and matched them to 689 controls according to age and time of blood draw. We genotyped two common polymorphisms in the gene coding VDBP, and calculated free and bioavailable 25(OH)D levels based on total 25(OH)D, VDBP, albumin, and their estimated genotype-specific binding affinities. Total 25(OH)D was associated with lower CRC risk (P for trend=0.01). Compared to women in the lowest quintile of total 25(OH)D, those in the highest quintile had an multivariable-adjusted odds ratio (OR) for CRC of 0.54 (95% CI, 0.33–0.87). Comparing extreme quintiles, we did not find any significant association with risk of CRC for VDBP (OR, 0.98; 95% CI, 0.65–1.47); free 25(OH)D (OR, 0.71; 95% CI, 0.46–1.10); or bioavailable 25(OH)D (OR, 0.92; 95% CI, 0.60–1.42). In conclusion, prediagnosis levels of total, but not free or bioavailable 25(OH)D, were associated with lower CRC risk. Although our findings support an inverse association of vitamin D with CRC, this association does not appear to be due to the unbound or bioavailable fraction of circulating vitamin D.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study

Song

Konijeti

Yuan

et al. 2016

Cancer Prevention Research

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“…A study in black and white American suggested that polymorphisms in Gc are also associated with the level of DBP protein itself, which in turn affects bioavailability of free vitamin D (Powe et al, 2013). In terms of cancer risk, recent evidences have suggested that DBP level was a risk-modifier of 25(OH) D in colorectal (Anic et al, 2014) and prostate cancer (Weinstein et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Maneechay¹,

Boonpipattanapong²,

Kanngurn³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: This case-control study aimed to determine if there were any associations between the two single nucleotide polymorphisms (SNPs) in Gc, rs7041 (Asp416Glu) and rs4588 (Thr420Lys) and 3 common cancers (breast, lung and colorectal) in Thai patients. Materials and Methods: Two hundred and eighty two colorectal, 101 breast and 113 lung cancer patients were recruited from one institute during 2011-2013. The controls were age-matched volunteers who had a negative history of index cancers. In addition, vitamin D levels were compared among different genotypes in the 2 SNPs. Results: The minor allele frequencies of rs7041 (G) and rs4588 (A) were 0.32 and 0.24, respectively. Under the dominant model, the study found significant associations between minor-allele genotypes of the SNP rs7041 (TG/GG) and lung cancer (odds ratio [OR] 1.78, 95% CI 1.05-3.03). When subgroup analysis was performed according to sex and age at diagnosis, the study found that the minorallele genotypes of rs7041 (TG/GG) were significantly associated with colorectal cancer in patients whose age at diagnosis was more than 60 years (OR 1.67, 95%CI 1.06-2.61) and the minor-allele genotypes of rs4588 (CA/AA) were significantly associated with colorectal cancer in males aged 60 years or less (OR 2.34, 95%CI 1.25-4.37). When SNP combinations (rs7041-rs4588) were examined, the TT-CA combination had a significant protective

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“…Finally, two studies (Anic, Weinstein, Mondul, Mannisto, & Albanes, 2014;Weinstein et al, 2015) evaluated the association between DBP and CRC with no significant results. …”

Section: Dbpmentioning

confidence: 99%