Serum YKL-40 is associated with the severity of coronary artery disease and hypertension

Yu, Xinguang; Guo, Juan; Li, Gai; Liu, Bo; Luo, Dong-Lei

doi:10.1016/j.asjsur.2020.08.016

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…YKL-40 and chitotriosidase belong to the same family, “mammalian chitinase-like proteins,” but YKL-40 is not a chitinase; rather, it binds tightly to chitin particles [ 28 ]. YKL-40 is a potential serum biomarker of distinct benign and malignant disease states, including diabetes mellitus, coronary artery disease, systemic sclerosis, psoriasis, dementia, benign prostatic hyperplasia, cervical cancer, and primary prostate cancer [ 14 – 17 , 28 , 29 ]. Unfortunately, there is scarce evidence for an association between YKL-40 and AP.…”

Section: Discussionmentioning

confidence: 99%

“…YKL-40 is a 40 kDa heparin-and chitin-binding glycoprotein, which is secreted by various cells, including vascular smooth muscle cells and macrophages. As a novel inflammatory marker, YKL-40 has been found to be elevated in several inflammatory and neoplastic disease conditions, including atherosclerosis, benign prostatic hyperplasia, diabetes mellitus, osteoarthritis (OA), polymyositis, psoriasis, rheumatoid arthritis, cervical cancer and primary prostate cancer [11][12][13][14][15][16][17][18]. Although Johansen et al [19] found elevated serum YKL-40 levels in AP patients, they failed to explore the relationship between chitotriosidase and conventional markers of inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers

Çetin¹,

Kamış²,

ÇETİN³

et al. 2021

Turk J Med Sci

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Background: Chitotriosidase and YKL-40, also called chitinase 3-like protein 1, are homologs of family 18 glycosyl hydrolases, secreted by human macrophages and granulocytes under inflammatory conditions. Although increased levels of chitotriosidase and YKL-40 are linked with several inflammatory diseases, the physiological utility of these two enzymes is still not fully characterized. This study aims to analyze the serum YKL-40 and chitotriosidase levels of acute pancreatitis patients to assess whether their activity correlates with acute pancreatitisand its severity.Methods: Chitotriosidase and YKL-40 levels, along with routine laboratory parameters, were determined from the serum samples of 41 acute pancreatitis patients, at both onset and remission (male/female: 22/19), and 39 healthy subjects (male/female: 19/20). The Modified Glasgow Prognostic Score was used to predict the severity of the disease, and a correlation analysis was performed between study variables.Results: A statistically significant increase in both chitotriosidase and YKL-40 levels was observed in acute pancreatitis patients compared to healthy controls (P < 0.001). Higher levels of YKL-40, chitotriosidase and C-reactive protein were found in patients with acute pancreatitis at onset than in remission. The correlation analysis showed a statistically significant association between YKL-40 and chitotriosidase (p = 0.039, r = 0.323). The cut-off point for YKL-40, for detecting acute pancreatitis, was 60.3 with a sensitivity and specificity of 84.9% and 84.6% (AUC: 0.890). The optimum cut-off point for chitotriosidase, for detecting acute pancreatitis, was 33.5 with a sensitivity and specificity of 79.5% and 78.4% (AUC: 0.899). Conclusion:Elevated YKL-40 and chitotriosidase levels in acute pancreatitis patients demonstrate the importance of possible macrophage involvement in the pancreatic microenvironment during acute pancreatitis progression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers

Çetin¹,

Kamış²,

ÇETİN³

et al. 2021

Turk J Med Sci

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“…YKL-40 can accelerate the formation of branch blood vessels, thereby changing the morphology of vascular endothelial cells, thereby affecting their functions [18,19] . The level of YKL-40 in patients with CHD has a certain relationship with the severity of the disease.…”

Section: Table 1: Comparison Of Blood Lipid Levels Between the Two Gr...mentioning

confidence: 99%

The Effect of Amlodipine Combined with Atorvastatin on the Levels of HMGB-1 and YKL-40 in Patients with Coronary Heart Disease and Carotid Atherosclerosis

Dong¹,

Ai²

2021

IJPS

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To observe the incidence of adverse reactions of amlodipine combined with atorvastatin in patients with coronary heart disease complicated with carotid atherosclerosis and the effect on the levels of high-mobility group box protein 1 and human cartilage glycoprotein 39. Retrospective analyses of patients with coronary heart disease combined with carotid atherosclerosis in our hospital are divided into two groups according to different treatment methods. The control group was given atorvastatin and the observation group was given amlodipine on this basis. The differences in blood lipid levels, myocardial enzyme levels, intima-media thickness levels, high-mobility group box protein 1 and human cartilage glycoprotein 39 changes before and after treatment were compared between the two groups. During the treatment period, there was no difference in the incidence of complications between the two groups. There was no difference in blood lipid levels between the two groups before treatment. After treatment, the levels of low-density lipoprotein cholesterol, triglycerides and total cholesterol in the observation group were lower than those in the control group and the levels of high-density lipoprotein cholesterol were higher than those in the control group. There was no difference in intima-media thickness before treatment between the two groups. At 4 and 8 w after treatment, the intima-media thickness value of the observation group was lower than that of the control group (p<0.05). There was no difference in the levels of high-mobility group box protein 1 and human cartilage glycoprotein 39 between the two groups before treatment. After treatment, the levels of high-mobility group box protein 1 and human cartilage glycoprotein 39 in the observation group were lower than those in the control group (p<0.001). There was no difference in myocardial enzyme indexes between the two groups before treatment. After treatment, the levels of lactate dehydrogenase and creatine kinase myocardial band of the two groups were lower than before treatment and the observation group was lower than the control group, the difference was statistically significant (p<0.001). Amlodipine combined with atorvastatin has a good therapeutic effect on patients with coronary heart disease complicated with carotid atherosclerosis and has good application value.

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Cardiac Overexpression of Chil1 Improves Wound Healing to Prevent Cardiac Rupture After Myocardial Infarction

Yang

Wei

et al. 2022

J. of Cardiovasc. Trans. Res.

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Serum YKL-40 is associated with the severity of coronary artery disease and hypertension

Cited by 6 publications

References 5 publications

Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers

Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers

The Effect of Amlodipine Combined with Atorvastatin on the Levels of HMGB-1 and YKL-40 in Patients with Coronary Heart Disease and Carotid Atherosclerosis

Cardiac Overexpression of Chil1 Improves Wound Healing to Prevent Cardiac Rupture After Myocardial Infarction

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