Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Zhang, Wenhua; Wu, Xinmou; Niu, Jing-Xiu; Hao, Yan; Wang, X.; Yin, Xiaodong; Pang, Yan

doi:10.7314/apjcp.2012.13.10.5043

Cited by 22 publications

(14 citation statements)

References 20 publications

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“…In the studies by Tanir et al (27) and Demirkirap et al (28), age did not have an effect on the incidence of cancer, while in another study by Dehaven et al (29), the rate of cancer increased with age increasing. The mean serum zinc level in patients with gastric adenocarcinoma was lower than that in patients with other gastrointestinal cancers with a significant difference similar to the studies of Zhang et al study (13), Li et al (14).…”

Section: Discussionsupporting

confidence: 85%

“…Generally, the consequent of zinc activity in the body reduces the number of tumor cells and decreases tumor volume (12). The results of some studies showed a difference in the serum levels of zinc between the patients with gastrointestinal cancers and healthy individuals (13)(14)(15)(16). According to the high prevalence of gastrointestinal cancers and the role of zinc in delaying oxidative reactions we intended to conduct a study on this subject.…”

Section: Key Pointmentioning

confidence: 99%

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Evaluation of serum zinc level as a risk factor for gastrointestinal cancers

Dizaji¹,

Babak²,

Bahadoram³

et al. 2017

Immunopathol Persa

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Introduction: Gastric adenocarcinoma and esophageal squamous cell carcinoma (ESCC) are the second and third common cancer in Iran respectively and are the leading causes of cancer deaths in the world. The status of serum zinc level in these cancers has not been fully evaluated. Objectives: The aim of the study was to compare serum zinc levels in patients with ESCC and gastric adenocarcinoma as compared to patients with other non-digestive cancers. Patients and Methods: This cross-sectional study was conducted on 100 consecutive patients (10 patients with SCC of the esophagus, 40 patients with gastric adenocarcinoma and 50 cases with other non-digestive cancers as the controls). Morning blood samples were taken containing 5 ml of blood from both groups and immediately stored in the laboratory at 8°C until all samples were taken. After collecting, serum levels of zinc in the specimens were measured by 24i chemistry analyzer. The SPSS version 23.0 for Windows was used for the statistical analysis. Results: The results of this study did not show a significant difference between mean serum level of zinc across the patients with ESCC and patients with gastric adenocarcinoma or those with other nondigestive cancers adjusted for age and gender (P > 0.05). However, a significant difference between the mean serum zinc level in patients with gastric adenocarcinoma and other non-digestive cancers was detected (P < 0.05). Conclusion: Regarding the normal serum level of zinc in other non-digestive cancers and a decrease in zinc level in gastrointestinal cancers in our study, malnutrition which is common in all malignancies, has no effect on zinc deficiency in gastrointestinal malignancies, and zinc deficiency can be considered as a primary risk factor for the development of these two digestive malignancies.

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Section: Discussionsupporting

confidence: 85%

Section: Key Pointmentioning

confidence: 99%

Evaluation of serum zinc level as a risk factor for gastrointestinal cancers

Dizaji¹,

Babak²,

Bahadoram³

et al. 2017

Immunopathol Persa

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“…(10) Zn is trace element found in blood, and most of it is contained in bones, skins, and hair (approximate 70%). Inverse associations were also obtained between serum Zn and risk of gastric cancer in some early studies, (11,12) but not all. (13) Higher level of Cu alone was also found significantly higher in cancerous human stomach in compared to normal samples.…”

Section: Introductionmentioning

confidence: 91%

Five Serum Trace Elements Associated with Risk of Cardia and Non-cardia Gastric Cancer in a Matched Case-control Study

Lin

Yan³

et al. 2019

Preprint

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Background : Serum trace elements have been some time suggested to influence the development of gastric cancer, but evidence is still lacking. Methods : In a case-control study from a high risk region of East China, all newly diagnosed patients with gastric cancer were compared with healthy controls 1:1 matched by sex, age (± 3 years) and place of residence during 2013- 2015. Results : A total of 299cases of gastric cancers, which included 122 cases of gastric cardia cancer (GCC) and 177 gastric non-cardia cancer (NCGC), and 299 healthy controls were included. Positive associations were found between serum copper and copper/zinc ratio and risk of overall gastric cancer (OR 4th vs. 1st quartile : 2.42, 95% CI: 1.10-5.32 for copper, p for trend=0.003; OR 4th vs. 1st quartile : 11.7, 95% CI: 3.83-35.6 for copper/zinc ratio, p for trend<0.0001), and for both GCC and NCGC subtypes. Serum selenium inversely associated with risk of NCGC (OR 4th vs. 1st quartile : 0.18, 95% CI: 0.07-0.51, p for trend=0.0001), while molybdenum seem to reduce risk of GCC (OR 4th vs. 1st quartile : 0.12, 95% CI: 0.03-0.47, p for trend<0.0001). Strong inverse associations were also detected between serum calcium and risk of all groups of gastric cancer (all p for trend<0.05). Although intermediate serum level of zinc and iron had lower risk of gastric cancer, no linear association was however found (all p for trend>0.05). Conclusions : The current study present evidences for positive associations between copper, copper/zinc ratio and gastric cancer, as well as for inverse associations between serum selenium, molybdenum and calcium and risk of gastric cancer.

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“…Gulmira Nigmetzhanovna Kulmambetova 1 *, Мeruert Kuatbekovna Imanbekova 1 , Аndrey Alexeevich Logvinenko 2 , Аdilbek Temirzhanovich Sukashev 2 , Мaxim Leonidovich Filipenko 3 , Еrlan Mirhaidarovich Ramanсulov 1 with gastritis increasing the risk of gastric cancer (Zhang et al, 2012). From another study exists evidence that key factor in development of gastric cancer p53 gene intron alterations may contribute gastritis development and early detection of these alterations in precancerous lesions such as gastritis may be useful for prediction of risk developing of gastric cancer (Najjar Sadeghi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%