Serum Zonulin Levels Are Higher Among Children with Autism Spectrum Disorders and Correlated with Social Impairment

Açıkel, Sadettin Burak; Çetinkaya, Miray; Tuncer, Sibel Çiğdem

doi:10.5152/alphapsychiatry.2021.21152

Cited by 4 publications

(2 citation statements)

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“…For ASD, intestinal and blood-brain barrier (BBB) dysfunction because of permeability changes has gained interest, too. In the development of ASD, increased intestinal and BBB permeability, which might contribute to an elevated inflammation, has been reported in some studies (Kara et al, 2021). However, it is seen that the data are extremely limited and many molecules that might play a role in permeability changes have not been investigated yet.…”

Section: Discussionmentioning

confidence: 99%

“…Although the cause–effect relationship between them is not clear, it is thought that individuals with autism have disturbances in intestinal permeability and that some bacterial metabolites (short‐chain fatty acids‐butyric acid) located in the brain‐intestinal axis might play a role in the etiology of ASD by affecting the gene expression through the histone deacetylation (Yenkoyan et al, 2017). Although studies with some markers regulating intestinal permeability contain evidence supporting this hypothesis (Kara et al, 2021; Karagözlü et al, 2022), the causality relationship of it is not yet clear (Fasano & Hill, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Serum trimethylamine N‐oxide and lipopolysaccharide binding protein levels among children diagnosed with autism spectrum disorder

Açıkel

Kara

Bağcı

et al. 2023

Intl J of Devlp Neuroscience

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In the literature, there have been several studies available investigating the relationship between autism spectrum disorder and intestinal permeability. In this study, it is aimed to examine the relationship between the levels of trimethylamine N‐oxide (TMAO), which is a parameter associated with intestinal permeability, and lipopolysaccharide binding protein (LBP), which is a marker associated with bacterial translocation from the intestine, in patients with autism spectrum disorder (ASD) and healthy controls. Fifty‐three children with ASD as the patient group and 30 healthy children as the control group have been included in the study. The diagnostic evaluation has been made according to DSM‐5 criteria. According to the obtained results, there has been no significant difference between groups in terms of serum TMAO and LBP levels. Considering the existence of various studies that found different results on ASD and intestinal permeability, it is thought that the studies conducted in this field that did not find statistically different results will also make a contribution to the literature.

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Section: Discussionmentioning

confidence: 99%