Serum α1-Acid Glycoprotein in Chronic Ulcerative Colitis

Dearing, William H.; McGuckin, Warren F.; Elveback, Lila R.

doi:10.1016/s0016-5085(69)80128-9

Cited by 37 publications

(17 citation statements)

References 9 publications

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“…Previous studies have made conflicting reports on the ability of ESR to predict disease activity in UC. Some studies have reported a good correlation [12,13], while others have shown no correlation between ESR and disease activity assessed clinically [7,13] or endoscopically [14]. We found a significant linear trend between the mean Lichtiger score and the ESR and CRP in the different disease severity subgroups.…”

Section: Discussionsupporting

confidence: 48%

CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease

Rodgers

Cummins

2007

Dig Dis Sci

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The aim of this study was to prospectively evaluate the correlation between clinical scoring systems and C-reactive protein (CRP) in inflammatory bowel disease. The modified Harvey-Bradshaw index was used in 40 patients (58 assessments) with Crohn's disease, and the Lichtiger score in 29 patients (36 assessments) with ulcerative colitis. In ulcerative colitis, CRP was elevated in 14%, 42%, 64%, and 83%, respectively, of subjects with quiescent, mild, moderate, and severe disease. There was a linear correlation of log(CRP) with clinical score except for proctitis. In Crohn's disease, CRP was elevated in 54%, 70%, 75%, and 100%, respectively, of subjects with quiescent, mild, moderate, and severe disease. We conclude that the clinical score has a good correlation with CRP in ulcerative colitis except for proctitis, whereas clinical score has a poor correlation with CRP in Crohn's disease, particularly in those with clinically quiescent, fibrostenotic, and ileal disease.

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Section: Discussionsupporting

confidence: 48%

CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease

Rodgers

Cummins

2007

Dig Dis Sci

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“…The synthesis of several serum proteins, the 'acute-phase reactants', increases in response to many stimuli including inflammation (Koj, 1974). Increased serum concentrations of many of these proteins have been reported in active ulcerative colitis and their concentrations rise as the activity of the colitis increases (Cooke et al, 1958;Dearing et al, 1969;Weeke and Jarnum, 1971;Mamer et al, 1975;Jensen et al, 1976). Conversely, the concentrations of the serum albumin and pre-albumin fall with increasing severity of ulcerative colitis (Weeke and Jarnum, 1971;Marner et al, 1975).…”

mentioning

confidence: 99%

Measurement of serum proteins during attacks of ulcerative colitis as a guide to patient management.

Buckell¹,

Lennard-Jones²,

Hernández³

et al. 1979

Gut

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SUMMARY Serial measurements of 11 serum proteins have been made throughout 39 admissions of 36 patients to hospital for the treatment of acute attacks of ulcerative colitis. There was a striking correlation between rapid changes in C-reactive protein and pre-albumin concentrations and the clinical response to medical treatment. Measurements of the a,-acid glycoprotein, albumin, and total serum protein concentrations at the time of admission were found to correlate with the outcome of the attack. Measurement of these proteins provides a useful guide to the management of patients with attacks of ulcerative colitis.

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“…On chemical fractionation of serum proteins a seromucoid fraction can be obtained which consists predominantly of acid ac-glycoprotein (orosomucoid). The concentration of this glycoprotein appears to be a valid indicator of the activity of Crohn's disease as well as of ulcerative colitis (Cooke, Fowler, Cox, Gaddie, and Meynell, 1958;Dearing, McGuckin, and Elveback, 1969).…”

mentioning

confidence: 99%

Serum concentration of 19 serum proteins in Crohn's disease and ulcerative colitis

Weeke¹,

Jarnum²

1971

Gut

118

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Certain proteins, 'the acute phase reactants' (orosomucoid, otl-antitrypsin, ol-antichymotrypsin, and haptoglobin) and the immunoglobulins were clinically useful, since their serum concentration reflected the grade of activity of the disease. A pronounced elevation of haptoglobin compared with that of the other 'acute phase reactants' was present in patients with Crohn's disease complicated by suppurative fistulas or abscesses. Patients with active Crohn's disease who responded favourably to medical treatment had significantly higher immunoglobulin levels than patients not responding. A similar observation, though not statistically significant, was made in patients with ulcerative colitis.

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Serum α1-Acid Glycoprotein in Chronic Ulcerative Colitis

Cited by 37 publications

References 9 publications

CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease

CRP Correlates with Clinical Score in Ulcerative Colitis but Not in Crohn’s Disease

Measurement of serum proteins during attacks of ulcerative colitis as a guide to patient management.

Serum concentration of 19 serum proteins in Crohn's disease and ulcerative colitis

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