Serumtransferrin bei chronisch h�modialysierten Patienten unter kontrollierter di�tetischer Eiwei�zulage

Quirin, H.; Jutzler, G. A.; Traut, R.; Baumann, G.; Bischof, Guido; Kluthe, R.

doi:10.1007/bf01467775

Cited by 12 publications

(5 citation statements)

References 4 publications

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“…A possible cause of this low diagnostic sensitivity might be the fact that the transferrin concentration is also dependent both upon the synthetic capacity of the liver s well s upon the protein intake (16). A possible cause of this low diagnostic sensitivity might be the fact that the transferrin concentration is also dependent both upon the synthetic capacity of the liver s well s upon the protein intake (16).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Transferrin Determination in Human Sera in the Diagnosis of Iron Deficiency

Withold

Neumayer²,

Beyrau³

et al. 1994

Clinical Chemistry and Laboratory Medicine

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Apparently healthy persons (n = 425) s well s 264 patients characterized by an iron concentration in serum < 7.2 μιηοΐ/ΐ were examined. A latent iron deficiency was defined s a concentration of ferritin < 20 μg/l (males) and < 15 μ^Ι (females), without anaemia; manifest iron deficiency defined by an additional presence of hypochromic microcytic anaemia.Fifty-nine of 425 (= 14%) apparently healthy persons showed a latent iron deficiency. In the remaining 366 we established the following reference intervals for the concentration of transferrin in serum [μιηοΐ/ΐ]: 25.2-45.3 (males), 29.1-54.5 (females, < 25 years of age) and 25.3-48.6 (females, > 25 years of age). Eight of 59 (= 14%) apparently healthy persons with latent iron deficiency had a transferrin concentration above the reference interval.Sixty-one of 264 (= 23%) patients with an iron concentration < 7.2 μπιοΐ/ΐ showed a ferritin concentration < 20 μg/l (males) and < 15 μg/l (females). Thirty-eight of these 61 patients (= 62%) had a manifest iron deficiency. In 18 of these 38 patients (= 47%) the transferrin concentration was increased.For our 264 patients we determined the diagnostic validity of an increased transferrin concentration for diagnosis of iron deficiency, assuming an iron deficiency if the concentration of ferritin remained below the discrimination values mentioned above: The diagnostic sensitivity was 36%, the diagnostic specificity 97%, the predictive value of the positive test result 79% and the predictive value of the negative test result 83%.It can be concluded that the diagnostic validity of transferrin determination is inferior to that of ferritin measurement with respect to the diagnosis of iron deficiency. This especially applies to diagnostic situations in which the prevalence of iron deficiency is far lower than in the present study: e. g., given a prevalence of iron deficiency anaemia of 0.81% s it can be observed in the general population the predictive value of the positive test result only amounts to 11.3%.Thus, determination of transferrin conceiitratiori does not yield further Information, so that this test should no longer be used in the diagnosis of iron deficiency.n. o uc ιοη j ron faficiency is categorized s follows (for review see Iron deficiency is the most common deficiency caused j c o)): world-wide by faulty feeding. About 10-12% of all adults are characterized by a negative iron balance, in chil-(a) Prelatent iron deficiency is characterized by an indren the frequency is higher and in pregnant women the creased absorption of iron (e. g., in the course of the value is more than 50%. Iron deficiency anaemia makes 59 Fe 2 * whole-body retention test) s well s by a deup more than 70% of all kinds of anaemia (1).creased amount of stored iron within the bone marrow.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Transferrin Determination in Human Sera in the Diagnosis of Iron Deficiency

Withold

Neumayer²,

Beyrau³

et al. 1994

Clinical Chemistry and Laboratory Medicine

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“…In support is the fact that the kidney is not the only site of erythropoietin production [19,21], while it certainly induces a normal erythropoietin feedback mechanism [18]. On the other hand, the increase of 2,3-DPG and ATP of the erythrocytes between the dialyses [15,23], may shift the oxygen dissociation curve of the hemoglo bin rightward, providing an increased amount of oxygen to the tissues, so as to 'deceive' the structures that produce erythropoietin.…”

Section: Discussionmentioning

confidence: 99%

“…According to L awson et al [14], a defi cient erythrocyte incorporation of r,9Fe exists. Transferrin values are con stantly reduced [10,23], Finally, the reduction or absence of erythropoie tin production appears to be of great importance in the genesis of anemia [5],…”

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confidence: 99%

Pathogenetic Aspects of Anemia in Long-Term Hemodialyzed Patients

Buscarini¹

1976

Acta Haematol

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“…This approach has previously proved to be effective [21]. In already malnourished renal patients, optimal enteral and parenteral nutritional management is mandatory as it will act favourably on their nutritional status [22–24].…”

Section: Discussionmentioning

confidence: 99%

Nutritional status and mortality of patients in regular dialysis therapy

Marckmann¹

1989

Journal of Internal Medicine

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The relationship between mortality and nutritional status of 48 chronic dialysis patients (32 patients on haemodialysis (HD) and 16 on continuous ambulatory peritoneal dialysis (CAPD)) was studied over a 24-month period. Patients were scored individually according to relative body weight (RBW), S-transferrin, mid-arm muscle circumference (MAMC) and triceps skinfold thickness (TSF), and were given a total score from 0 (normal nutritional status) to 8 (severe protein-caloric malnutrition) at start of observation. The observation period was characterized by a significantly lower total nutritional score among surviving (n = 39) patients than among patients who died (n = 9) (Mann-Whitney, P less than 0.001). There was no difference in mortality between the two kinds of dialysis therapy (HD,CAPD). In conclusion, chronic dialysis patients with a poor nutritional status have a highly increased mortality. The presumably causal nature of this relationship makes prevention of protein-caloric malnutrition among dialysis patients a high priority task.

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Serumtransferrin bei chronisch h�modialysierten Patienten unter kontrollierter di�tetischer Eiwei�zulage

Cited by 12 publications

References 4 publications

Efficacy of Transferrin Determination in Human Sera in the Diagnosis of Iron Deficiency

Efficacy of Transferrin Determination in Human Sera in the Diagnosis of Iron Deficiency

Pathogenetic Aspects of Anemia in Long-Term Hemodialyzed Patients

Nutritional status and mortality of patients in regular dialysis therapy

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