Sesame Seed Lignans and γ-Tocopherol Act Synergistically to Produce Vitamin E Activity in Rats ,

Yamashita, Kanae; Nohara, Yuuko; Katayama, Kumiko; Namiki, Mitsuo

doi:10.1093/jn/122.12.2440

Cited by 125 publications

(74 citation statements)

References 32 publications

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“…We have studied the effect of dietary sesame lignan on the tocopherol metabolism in rats (1)(2)(3)(4)(5). Ascorbic acid is a potent water-soluble antioxidant that has a protective effect against some oxidative stress associated with tocopherol.…”

Section: Discussionmentioning

confidence: 99%

Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats

Ikeda

Abe

Uchida

et al. 2007

J Nutr Sci Vitaminol

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SummaryWe previously showed that the intake of sesamin, a major lignan in sesame seed, decreased lipid peroxidation and elevated tocopherol concentration in rat tissues. In this study, we examined the effect of dietary sesame seed and sesamin on the ascorbic acid concentration in rat tissues. Rats (4-wk-old) were fed either a vitamin E-free diet, or a diet containing 50 mg ␥ -tocopherol/kg, one containing 2 g sesamin/kg, one containing 50 mg ␥ -tocopherol/kg and 2 g sesamin/kg, or one containing 200 g sesame seed/kg for 28 d. The dietary sesamin and sesame seed elevated ascorbic acid concentrations in the liver and kidney, and increased urinary excretion in those Wistar rats. The dietary sesamin also elevated the hepatic mRNA levels of cytochrome P450 (CYP) 2B, and UDP-glucuronosyltransferase (UGT) 1A and 2B. In contrast, neither the sesamin nor the sesame seed affected the liver concentration of ascorbic acid in ODS rats with a hereditary defect in ascorbic acid synthesis, though the dietary sesame seed elevated the UGT1A and 2B mRNA levels in the liver. In addition, the sesame seed elevated the ␥ -tocopherol concentration in the various ODS rat tissues and the ascorbic acid concentrations in the kidney, heart and lung, while reducing the thiobarbituric acid reactive substance concentration in the heart and kidney. These results suggest that dietary sesame seed and its lignan stimulate ascorbic acid synthesis as a result of the induction of UGT1A and the 2B-mediated metabolism of sesame lignan in rats. The data of ODS rat studies also suggest that dietary sesame seed enhances antioxidative activity in the tissues by elevating the levels of two antioxidative vitamins, vitamin C and E. Key Words ascorbic acid, sesamin, sesame seed, UDP-glucuronosyltransferase, vitamin C Dietary sesame seed or its lignan, such as sesamin and sesaminol, elevates tocopherol concentration in the serum and tissues of rats fed tocopherol ( 1 -5 ). Dietary sesame lignan elevates the tocopherol concentration in tissues by inhibiting tocopherol metabolism to its metabolite because the dietary sesamin or sesaminol markedly decreases the urinary excretion of 2,7,8-trimethyl-2(2 ′ -carboxyethyl)-6-hydroxychroman ( ␥ -CEHC), a major metabolite of ␥ -tocopherol, in rats fed a diet containing ␥ -tocopherol ( 4 ). We also showed that the concentration of thiobarbituric acid reactive substance (TBARS) in the tissues and plasma (or serum) was decreased by dietary sesame seed or its lignan ( 1 , 2 , 4 , 5 ). It was recently reported that dietary sesame seed or sesame oil consumption reduced the urinary excretion of ␥ -CEHC ( 6 ), elevated the plasma (or serum) ␥ -tocopherol concentration ( 7-9 ), and decreased serum TBARS concentration ( 9 ) in humans. These data suggest that dietary sesame lignan elevates tocopherol concentration in the serum and tissues by inhibiting its metabolism, and decreases lipid peroxidation by inducing a high tocopherol concentration in humans and rats.

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Section: Discussionmentioning

confidence: 99%

Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats

Ikeda

Abe

Uchida

et al. 2007

J Nutr Sci Vitaminol

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“…참깨 종자로부터 분리된 리그난 성 분에는 세사민, 세사몰린, 피노레지놀, 피페리톨, 코부신, 에 피세사민, 세사미놀 등이 있고 주성분은 지용성인 세사민과 세사몰린이다 Fukuda et al, 1986;Kato et al, 1998). 세사민은 인체 내에서 뚜렷한 항산화 활 성을 나타낸 것으로 보고되었는데 γ-토코페롤과 협동적으 로 작용하여 쥐에서 비타민 E 활성을 생성하고 α-토코페롤 이 적은 식단을 먹인 쥐에서 뚜렷한 비타민 E 활성 강화효 과가 보고되었다 (Yamashita et al, 1992(Yamashita et al, , 1995. 또한 비타 민 E 뿐만 아니라 비타민 K 활성 강화효과도 보고되었다 (Hanzawa et al, 2013).…”

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Variation of Lignan Content for Sesame Seed Across Origin and Growing Environments

김성업¹,

오기원²,

이명희³

et al. 2014

Korean Journal of Crop Science

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Sesame lignan, including sesamin and sesamolin has been reported to have various content according to accessions and environmental factors. The objective of this study were to analyze the lignan variation of 143 sesame accessions from core collection in Korea and to test the effects of growing years and locations on lignan and lipid content of Korea sesame elite lines. The results showed that the core sesame germplasm in Korea has broad variation of lignan content from 2.33 to 12.17 mg/g with an average 8.18 mg/g. Among tested sesame accessions, the IT184615 had the highest lignan content of as 12.17 mg/g. So this accession will be a good genetic resource for developing a high lignan sesame variety. The sesamin and sesamolin content for sesame accessions across origin had significant difference. The average lignan content of accessions collected from Russia (10.0 mg/g) and Nepal (9.08 mg/g) were relatively higher than other countries. The sesamin and sesamolin content for sesame accessions across seed coat color had significant difference. The average lignan content of sesame with white, brown and black seed coat color was 8.61, 7.51, and 5.49 mg/g, respectively. The variation of lignan and lipid content was significantly different across elite lines, locations and growing years. Therefore, it is important to find sesame accessions having high lignan content with environmental stability.

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“…In nature, compounds with vitamin E activity are ␣ -, ␤ -, ␥ -or ␦ -tocopherols and ␣ -, ␤ -, ␥ -or ␦ -tocotrienols. Dietary sesame seed or its lignans, such as sesamin and sesaminol, markedly elevate ␥ -tocopherol concentration in rat plasma and tissues ( 1 ). The elevation of the ␥ -tocopherol concentration by sesame lignan is accompanied by inhibition of urinary excretion of 2,7,8-trimethyl-2(2 ′ -carboxyethyl)-6-hydroxychroman ( ␥ -CEHC), a ␥ -tocopherol metabolite ( 2 ).…”

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confidence: 99%

Dietary Sesame Seed Decreases Urinary Excretion of .ALPHA.- and .GAMMA.-Tocopherol Metabolites in Rats

Uchida

Ichikawa

Abe

et al. 2007

J Nutr Sci Vitaminol

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SummaryWe previously showed that dietary sesame seed and its lignan inhibited ␥ -tocopherol metabolism to 2,7,8-trimethyl-2(2 ′ -carboxyethyl)-6-hydroxychroman ( ␥ -CEHC), a ␥ -tocopherol metabolite, and markedly elevated tissue ␥ -tocopherol concentration in rats. The aim of this study was to clarify the effect of dietary sesame seed on ␣ -tocopherol metabolism. Vitamin E-deficient rats fed a vitamin E-free diet for 4 wk were fed a diet containing ␣ -tocopherol, ␣ -and ␥ -tocopherol, or ␣ -tocopherol with sesame seed for 7 d. Urinary excretion of 2,5,7,8-tetramethyl-2(2 ′ -carboxyethyl)-6-hydroxychroman ( ␣ -CEHC), a ␣ -tocopherol metabolite, in rats fed ␣ -tocopherol with sesame seed was inhibited ( p Ͻ 0.05) as compared with that in rats fed ␣ -tocopherol alone, or ␣ -and ␥ -tocopherol. The ␥ -CEHC excretion was also less ( p Ͻ 0.05) in rats fed ␣ -tocopherol with sesame seed than that in rats fed ␣ -and ␥ -tocopherol. The inhibition of ␣ -and ␥ -CEHC excretion by sesame seed was accompanied by elevation ( p Ͻ 0.05) of the ␣ -and ␥ -tocopherol concentration in the liver. These results suggest that dietary sesame seed inhibits not only ␥ -tocopherol metabolism to ␥ -CEHC but also ␣ -tocopherol metabolism to ␣ -CEHC in rats. Key Words rats, sesame seed, tocopherol, vitamin E Vitamin E is a potent fat-soluble antioxidant that inhibits lipid peroxidation in biological membranes. In nature, compounds with vitamin E activity are ␣ -, ␤ -, ␥ -or ␦ -tocopherols and ␣ -, ␤ -, ␥ -or ␦ -tocotrienols. Dietary sesame seed or its lignans, such as sesamin and sesaminol, markedly elevate ␥ -tocopherol concentration in rat plasma and tissues ( 1 ). The elevation of the ␥ -tocopherol concentration by sesame lignan is accompanied by inhibition of urinary excretion of 2,7,8-trimethyl-2(2 ′ -carboxyethyl)-6-hydroxychroman ( ␥ -CEHC), a ␥ -tocopherol metabolite ( 2 ). In addition to the animal studies, several reports showed that the dietary sesame seed or sesame oil elevated plasma (serum) ␥ -tocopherol concentration in humans ( 3-5 ). Frank et al. ( 6 ) recently reported that consumption of sesame oil muffins significantly decreased the urinary excretion of ␥ -CEHC in humans. Therefore, sesame lignan elevates the ␥ -tocopherol concentration in the serum and tissues by inhibiting ␥ -tocopherol metabolism to ␥ -CEHC in humans and rats.Despite our daily intake of relatively large amount of ␥ -tocopherol, the ␣ -tocopherol concentration in the serum and tissues is much higher than the ␥ -tocopherol concentration because of the discrimination of vitamin E isoforms by ␣ -tocopherol transfer protein ( ␣ -TTP) in the liver. Thus, ␣ -tocopherol is the most biologically active form of vitamin E and inhibits lipid peroxidation of membranes. Sesame seed or its lignan also elevates the ␣ -tocopherol concentration in the serum and tissues of rats ( 7-9 ), or the plasma ratio of ␣ -tocopherol to total cholesterol in human ( 5 ). Sesamin clearly inhibits the production of not only ␥ -CHEC but also 2,5,7,8-tetramethyl-2(2 ′ -carboxyethyl)-6-hy...

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Sesame Seed Lignans and γ-Tocopherol Act Synergistically to Produce Vitamin E Activity in Rats ,

Cited by 125 publications

References 32 publications

Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats

Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats

Variation of Lignan Content for Sesame Seed Across Origin and Growing Environments

Dietary Sesame Seed Decreases Urinary Excretion of .ALPHA.- and .GAMMA.-Tocopherol Metabolites in Rats

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