Sesamin Induces the Transdifferentiation of Type II Alveolar Epithelial Cells via AnnexinA1 and TRPV1

Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells

“…AKT signaling functions as a hub for multiple pathways, including cell survival and proliferation, and is important for AT2 cell proliferation ( Portnoy et al., 2004 ). A few reports have suggested its involvement in AT2-to-AT1 cell differentiation ( Zhang et al., 2023 ; Zhong et al., 2022 ), although it has not been sufficiently evaluated. Furthermore, since recent transcriptomic analysis indicated that AKT signaling can be affected in the transitional state of alveolar epithelial cells observed in damaged fibrotic lungs ( Kobayashi et al., 2020 ; Xu et al., 2016 ), we hypothesized that AKT signaling may be associated with AT2-to-AT1 cell differentiation.…”